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Chemical Structure| 1374641-74-3 Chemical Structure| 1374641-74-3

Structure of 1374641-74-3

Chemical Structure| 1374641-74-3

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Product Details of [ 1374641-74-3 ]

CAS No. :1374641-74-3
Formula : C10H7Cl2N3O
M.W : 256.09
SMILES Code : NC1=CC=CC(OC2=NC(Cl)=NC=C2Cl)=C1

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Application In Synthesis of [ 1374641-74-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1374641-74-3 ]

[ 1374641-74-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 76661-24-0 ]
  • [ 1374641-74-3 ]
YieldReaction ConditionsOperation in experiment
78% With iron; ammonium chloride; In tetrahydrofuran; water; at 65℃; for 3.0h; Intermediate 1-4 (0.48 g, 1.68 mmol) was dissolved in a solution of THF (50 ml) and water (50 ml). Iron powder (0.47g, 8.4mmol) and ammonium chloride (0.45g, 8.4mmol) were added, and the reaction solution was heated to 65C and stirred for 3 hours. After the reaction mixture was cooled, it was filtered through Celite. After the reaction solution was concentrated in vacuo, it was neutralized with sodium carbonate, and extracted three times with EA (20 ml). The organic layer was separated, dried with anhydrous sodium sulfate, concentrated, and column chromatography to obtain product 1-5b with a yield of 78%.
 

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