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Chemical Structure| 13798-75-9 Chemical Structure| 13798-75-9
Chemical Structure| 13798-75-9

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Product Details

CAS No. :13798-75-9
Formula : C20H24N2O8
M.W : 420.41
SMILES Code : O=C(ON1C(CCC1=O)=O)[C@@H](NC(OC(C)(C)C)=O)CC(OCC2=CC=CC=C2)=O
MDL No. :MFCD00037912

Safety

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 13798-75-9 ]

[ 13798-75-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13798-75-9 ]
  • [ 2886-33-1 ]
  • [ 104870-31-7 ]
YieldReaction ConditionsOperation in experiment
11.6 g With triethylamine; In N,N-dimethyl-formamide; at 20℃; for 1.38333h;pH 4.5; L-Aspartic acid dibenzyl ester 4-toluenesulfonate, 9.7 g (20 mmol) was dissolved with brief heating in 12.5 ml anhydrous DMF. To this, now at ambient temperature, was added a solution of 8.4 g (20 mmol) Boc-L-aspartic acid B-benzyl ester N-hydroxysuccinimide ester in 12 ml anhydrous DMF, followed by 2.8 ml (~ 21 mmol) triethylamine with stirring. A 10-fold dilution of a sample into water measured pH 4.5 with indicator paper. The reaction was followed by injection of a 10-fold dilution into MeOH onto a Prodigy C-18 150 x 4.6 mm HPLC column eluted at ambient temperature with ACN/0.l% TFA (11 :9) at 2 ml/min with photodiode array detection. Analysis at 83 minutes indicated that all of both starting materials had been consumed. Solvent was removed by rotary evaporation at reduced pressure, 60 ml of ethyl acetate added, the resulting solution washed with 3 x 75 ml of water. Solvent was removed by rotary evaporation at reduced pressure and the product dried under high vacuum over P205 to give 11.6 g of BOC-Asp-Asp-Bn3 as a light tan powder.
 

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