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[ CAS No. 1383001-27-1 ] {[proInfo.proName]}

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Chemical Structure| 1383001-27-1
Chemical Structure| 1383001-27-1
Structure of 1383001-27-1 * Storage: {[proInfo.prStorage]}
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CAS No. :1383001-27-1 MDL No. :N/A
Formula : C8H8BrClN2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 279.52 Pubchem ID :-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

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[ 1383001-27-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1383001-27-1 ]
  • [ 885168-04-7 ]
YieldReaction ConditionsOperation in experiment
71% With lithium aluminium tetrahydride In tetrahydrofuran at -70℃; for 2.25 h; To a solution of 5-bromo-3-chloro-N-methoxy-N-methylpicolinamide (9.0 g, 32.3 mmol, 1 eq) in THF (100 mL), the LAH solution (IM in THF) (16.12 mL, 16.1 mmol, 0.5 eq) was added at -70°C for 15 mm. Reaction was continued at the same temperature for another 2 h. After completion of reaction (monitored by TLC), RM was quenched with sat. Na2SO4 solution and extracted with EtOAc (3x250 mL). The organiclayer was washed with water (500 mL), brine (500 mL), dried over Na2SO4, filtered and the solvent was evaporated under reduced pressure to get the crude product which was purified by flash CC to afford 5- bromo-3-chloropicolinaldehyde (5.0 g, 71percent) as brown gum.
Reference: [1] Patent: WO2015/158427, 2015, A1, . Location in patent: Page/Page column 68
[2] Patent: WO2012/81736, 2012, A1, . Location in patent: Page/Page column 102-103
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