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Chemical Structure| 138498-96-1 Chemical Structure| 138498-96-1

Structure of 138498-96-1

Chemical Structure| 138498-96-1

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Product Details of [ 138498-96-1 ]

CAS No. :138498-96-1
Formula : C6H8O3
M.W : 128.13
SMILES Code : O=C(O)C=C1COCC1

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Application In Synthesis of [ 138498-96-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 138498-96-1 ]

[ 138498-96-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 22929-52-8 ]
  • (carbethoxymethyene)triphenylphosphorane [ No CAS ]
  • [ 138498-96-1 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; LiOH; In ethanol; acetonitrile; EXAMPLE 25 Preparation of (4,5-dihydro-3(2H)-furylidene)acetic acid A mixture of 3.9 g of <strong>[22929-52-8]tetrahydrofuran-3-one</strong> and 22 g of (carbethoxymethyene)triphenylphosphorane in 40 mL of anhydrous acetonitrile was heated to reflux for 4 days. After concentration, the residue was purified by chromatography on silica gel. Elution with 25percent ethyl acetate in hexanes gave, after evaporative distillation at 15 mm (oven temperature 140°C), 3.6 g of product as a fragrant liquid. The ester was saponified in 20 mL of ethanol with 20 mL of 1N LiOH for 24 hours. After acidification with 6N HCl to pH2, the acid was isolated by concentration to dryness and extraction with methylene chloride. Azeotropic drying with toluene gave 3.1 g of product as a resinous solid.
 

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