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Chemical Structure| 1386982-02-0 Chemical Structure| 1386982-02-0

Structure of 1386982-02-0

Chemical Structure| 1386982-02-0

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Product Details of [ 1386982-02-0 ]

CAS No. :1386982-02-0
Formula : C19H16F4N2O4
M.W : 412.34
SMILES Code : O=C1N(C[C@@H](N)CC2=CC=CC(F)=C2)C(C3=C1C=CC=C3)=O.O=C(O)C(F)(F)F

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Application In Synthesis of [ 1386982-02-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1386982-02-0 ]

[ 1386982-02-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1201923-48-9 ]
  • [ 1386982-02-0 ]
YieldReaction ConditionsOperation in experiment
With trifluoroacetic acid; In dichloromethane; at 20℃; for 1.0h; A mixture [(S)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-2-(3-fluoro-phenyl)-ethyl]carbamic acid tert-butyl ester (1.203 g, 3 mmol) and trifluoroacetic acid-dichloromethane (15 mL, 2:1) was stirred at room temperature for 1 hour and then concentrated under reduced pressure to give crude 2-[(S)-2-amino-3-(3-fluoro-phenyl)-propyl]-isoindole-1,3-dione trifluoroacetic acid salt. (Yield 1.516, 123%).
 

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[ 1386982-02-0 ]

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Reason: Free-salt