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[ CAS No. 13947-21-2 ] {[proInfo.proName]}

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Chemical Structure| 13947-21-2
Chemical Structure| 13947-21-2
Structure of 13947-21-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 13947-21-2 ]

CAS No. :13947-21-2 MDL No. :MFCD00661186
Formula : C8H6ClNO3S Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 231.66 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 13947-21-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 13947-21-2 ]

[ 13947-21-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 870-72-4 ]
  • [ 81-07-2 ]
  • [ 13947-21-2 ]
  • 2
  • [ 75-15-0 ]
  • [ 13947-21-2 ]
  • [ 10262-69-8 ]
  • [ 914928-31-7 ]
YieldReaction ConditionsOperation in experiment
Stage #1: carbon disulfide; maprotiline With potassium hydroxide In ethanol at 20℃; for 1h; Stage #2: N-chloromethylsaccharin In ethanol for 1h; Heating;
  • 3
  • [ 50-00-0 ]
  • [ 81-07-2 ]
  • [ 13947-21-2 ]
YieldReaction ConditionsOperation in experiment
91% With thionyl chloride; sodium hydrogensulfite Heating;
89% Stage #1: formaldehyd; saccharin In water Heating; Stage #2: With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20℃; Further stages.;
36% Stage #1: formaldehyd; saccharin In water at 100℃; for 1h; Stage #2: With thionyl chloride at 75℃; for 0.5h; BSc5195: BSc5195 was synthesized according to previously reported methods.1,8 Briefly,saccharin (1.83 g, 10.0 mmol, 1.0 equiv) and formaldehyde (2.4 mL of 37% solution in water, 30.0mmol, 3.0 equiv) were placed in 10 mL of water and stirred at 100 °C for 1 h. The reaction mixturewas then cooled to 0 °C, and the resulting white precipitate (1.85 g, 8.7 mmol) was collected byfiltration and used in the next step without further purification. The intermediate was placed inthionyl chloride (1.9 mL, 26.1 mmol, 3.0 equiv), and the resulting mixture was stirred at 75 °C for30 min. The mixture was concentrated under reduced pressure and then purified by columnchromatography (3:1 DCM/hexanes) to give N-chloromethyl saccharin (0.84 g, 3.6 mmol, 36%over two steps).
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