There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 139504-50-0 | MDL No. : | MFCD28398157 |
Formula : | C35H48ClN3O10S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 738.29 | Pubchem ID : | - |
Synonyms : |
Maytansinoid DM 1;Mertansine;emtansine;maytansine, Mertansine;UNII-DDZ29HGH0E;DM1 [Maytansinoid];DM1 Compound
|
Chemical Name : | (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-Chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(3-mercaptopropanoyl)-N-methyl-L-alaninate |
Num. heavy atoms : | 50 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.6 |
Num. rotatable bonds : | 9 |
Num. H-bond acceptors : | 10.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 197.25 |
TPSA : | 195.27 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | Yes |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | Yes |
Log Kp (skin permeation) : | -9.23 cm/s |
Log Po/w (iLOGP) : | 4.81 |
Log Po/w (XLOGP3) : | 2.21 |
Log Po/w (WLOGP) : | 3.07 |
Log Po/w (MLOGP) : | 1.69 |
Log Po/w (SILICOS-IT) : | 2.81 |
Consensus Log Po/w : | 2.92 |
Lipinski : | 2.0 |
Ghose : | None |
Veber : | 1.0 |
Egan : | 1.0 |
Muegge : | 2.0 |
Bioavailability Score : | 0.17 |
Log S (ESOL) : | -5.3 |
Solubility : | 0.00366 mg/ml ; 0.00000496 mol/l |
Class : | Moderately soluble |
Log S (Ali) : | -5.95 |
Solubility : | 0.000838 mg/ml ; 0.00000113 mol/l |
Class : | Moderately soluble |
Log S (SILICOS-IT) : | -5.66 |
Solubility : | 0.00163 mg/ml ; 0.00000221 mol/l |
Class : | Moderately soluble |
PAINS : | 0.0 alert |
Brenk : | 3.0 alert |
Leadlikeness : | 2.0 |
Synthetic accessibility : | 8.63 |
Signal Word: | Danger | Class: | 8,6.1 |
Precautionary Statements: | P201-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338+P310-P308+P313 | UN#: | 2923 |
Hazard Statements: | H302-H311-H314-H340-H350 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.