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Chemical Structure| 1400674-68-1 Chemical Structure| 1400674-68-1

Structure of 1400674-68-1

Chemical Structure| 1400674-68-1

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Product Details of [ 1400674-68-1 ]

CAS No. :1400674-68-1
Formula : C16H24O6
M.W : 312.36
SMILES Code : O=C(OCC)[C@]1(CC[C@@H](CC1)C2C(OC(C)(OC2=O)C)=O)C

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Application In Synthesis of [ 1400674-68-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1400674-68-1 ]

[ 1400674-68-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2033-24-1 ]
  • [ 147905-77-9 ]
  • [ 1400674-68-1 ]
  • [ 1354806-09-9 ]
YieldReaction ConditionsOperation in experiment
With sodium tris(acetoxy)borohydride; In N,N-dimethyl-formamide; at 20℃; for 4h; The compound (3.68 g) produced in Example 45 and Meldrum's acid (3.17 g) were dissolved in 40 mL of dimethylformamide, sodium triacetoxyborohydride (5.09 g) was added while stirring at room temperature, and the mixture was stirred at that temperature for 4 hours. After completion of the reaction, 300 mL of water was added, and extraction operation (hexane:ethyl acetate=3:1) was performed. The resulting organic layer was sequentially washed with an aqueous saturated sodium bicarbonate solution and an aqueous saturated sodium chloride solution, and dried with magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain 6.8 g of the crude product. The crude product was purified by silica gel column chromatography (ethyl acetate/hexane=18%?29%) to obtain an isomer mixture (3.36 g) of trans:cis=10:11. The isomer mixture was dissolved in 4 mL of ethyl acetate, and the solution was allowed to stand at room temperature overnight. The precipitated crystal was filtered, and dried under reduced pressure to obtain the title compound (437 mg) having the following physical property values.; TLC: Rf 0.48 (hexane:ethyl acetate=2:1); 1H-NMR (CDCl3): delta 1.12-1.29 (m, 8H), 1.48-1.60 (m, 2H), 1.67-1.87 (m, 8H), 2.24-2.46 (m, 3H), 3.33 (d, J=3.3 Hz, 1H), 4.17 (q, J=7.2 Hz, 2H).
 

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