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Chemical Structure| 1400997-35-4 Chemical Structure| 1400997-35-4

Structure of 1400997-35-4

Chemical Structure| 1400997-35-4

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Product Details of [ 1400997-35-4 ]

CAS No. :1400997-35-4
Formula : C8H6BrFO
M.W : 217.04
SMILES Code : FC1=CC(C2OC2)=CC=C1Br
MDL No. :MFCD24108103

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Application In Synthesis of [ 1400997-35-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1400997-35-4 ]

[ 1400997-35-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003879-02-4 ]
  • [ 1400997-35-4 ]
YieldReaction ConditionsOperation in experiment
94% With sodium tetrahydroborate; In ethanol; at 5 - 50℃; for 7.083h; a) 2-(4-Bromo-3-fluoro-phenyl)-oxirane 2-Bromo-l-(4-bromo-3-fiuorophenyl)-ethanone [CAS 1003879-02-4] (32.3 g, 109 mmol) was dissolved in ethanol (250 ml). The reaction mixture was cooled to 5 C to give a yellow suspension. Sodiumborohydride (4.13 g, 109 mmol) was added over 5 min. The reaction mixture was stirred at room temperature for 1 hour. Sodium methoxide (2.95 g, 54.6 mmol) was added. The reaction mixture was stirred at 50 C for 6 h. The reaction mixture was poured into tert.butyl methyl ether and extracted with brine. The organic layer was dried over MgS04 and concentrated in vacuo to yield a yellow oil (25.1 g, 94%). GC-EI-MS : 216 ([M +]).
 

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