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CAS No. :	214358-33-5
Formula :	C₁₀H₁₇Cl₂N₃
M.W :	250.17
SMILES Code :	CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl
Synonyms :	1400W (hydrochloride); N-(3-(Aminomethyl)benzyl)acetamidine; 1400W Dihydrochloride
MDL No. :	MFCD03428622

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Aortic rings	744 µM (IC 50)	15 minutes	Evaluate the inhibitory effect of 1400W on ACh-evoked cGMP synthesis	Br J Pharmacol. 2013 Mar;168(5):1255-65.
Hippocampal slices	150 µM (IC 50)	15 minutes	Evaluate the inhibitory effect of 1400W on NMDA-evoked cGMP accumulation	Br J Pharmacol. 2013 Mar;168(5):1255-65.
Macrophages	10 nM	15–18 hours	Inhibition of NOS2 activity, reducing Lm spread between macrophages	Immunity. 2012 May 25;36(5):807-20.
HK-2 cells	100 μg/mL	24 hours	To evaluate the effect of 1400W on ROS production in HK-2 cells, results showed that 1400W reduced ROS levels.	Br J Pharmacol. 2020 Jan;177(1):110-127.
Microglia cell line	10, 50, 100, 150 µM	24 hours	To confirm the bioactivity of 1400W by determining the suppression of LPS-induced nitrite levels in the media.	Neurobiol Dis. 2020 Jan;133:104443.
N/TERT keratinocytes	1 µM	8 days	Inhibition of NOS2 significantly improved the skin barrier formation in the HI 3D model, restoring the lipid barrier.	J Clin Invest. 2020 Sep 1;130(9):4798-4810.
COH-BR1 cells	10 µM	8-20 hours	To evaluate the effect of iNOS inhibition on PDT-induced apoptosis, results showed that 1400W significantly enhanced apoptosis.	Free Radic Biol Med. 2013 Apr;57:39-48.
MDA-MB-231 cells	10 µM		To evaluate the effect of 1400W on PDT-induced apoptosis, results showed that 1400W significantly enhanced apoptosis.	Free Radic Biol Med. 2013 Apr;57:39-48.

Sprague Dawley rats	Aged rat model	Intraperitoneal injection	1 mg/kg	Single dose, sacrificed 30 minutes after treatment	1400W markedly improved ACh-induced vasorelaxation (maximal relaxation: 87%±8%, P<0.05), while having no effect on acidified NaNO2-induced vasorelaxation.	Acta Pharmacol Sin. 2010 Oct;31(10):1324-8
Sprague-Dawley rats	Insulin resistance model	Subcutaneous injection	1 mg/kg	Twice daily for 7 days	1400W significantly reversed or attenuated hyperglycaemia, hyperinsulinaemia, insulin resistance (HOMA index), body weight gain, peroxynitrite formation (nitrotyrosine expression) and the up-regulation of biomarkers of inflammation (B1 receptor, carboxypeptidase M, iNOS and IL-1β) in renal cortex and aorta and to some extent in the liver.	Br J Pharmacol. 2016 Jun;173(12):1988-2000
Mice	Murine model of oxygen-induced retinopathy of prematurity	Subcutaneous injection	1 mg/ml	Every 8 hours from P12 to P17	To evaluate the potential utility of iNOS inhibitors for therapeutic use in ischemic retinopathy, the results showed that 1400W significantly reduced the size of the central capillary-free area and inhibited intravitreal neovascularization.	J Clin Invest. 2001 Mar;107(6):717-25
Mice	GSNOR-deficient mice	Intraperitoneal injection	1 μg/g	Twice daily for 4 days	Inhibition of iNOS activity, prevention of AGT depletion, reduction of O6-etdG lesions, and decrease in hepatocarcinogenesis	Cancer Res. 2013 May 1;73(9):2897-904
C57BL/6 mice	Systemic Lm infection model	Intraperitoneal injection	10 mg/kg	Once at 0 and 24 hours post infection	Inhibition of NOS2 activity, reducing Lm spread and burden in the liver	Immunity. 2012 May 25;36(5):807-20.
Mice	High-fat diet-induced obesity model	Oral	10 mg/kg	Once daily for 28 days	To evaluate the effect of 1400W on obesity-induced chronic kidney disease, results showed that 1400W did not significantly improve kidney function.	Br J Pharmacol. 2020 Jan;177(1):110-127.
Wistar rats	Hypoxia/re-oxygenation model	Intraperitoneal injection	10 mg/kg	Single administration, observed for 48 hours and 5 days	To investigate the effects of 1400W on lung injury under hypoxia/re-oxygenation conditions in rats. Results showed that 1400W reduced NOx levels, decreased lipid peroxidation, apoptotic cell percentage, and nitrated protein expression, indicating a negative role of iNOS-derived NO in lung hypoxia/re-oxygenation.	Redox Rep. 2010;15(4):169-78
C57 BL6/J mice	Bleomycin-induced lung injury model	Subcutaneous osmotic pump	10 mg/kg/h	Continuous administration starting six days prior to ITB	Continuous administration of 1400 W via osmotic pump significantly attenuated bleomycin-induced lung inflammation, decreased chemotactic activity of the bronchoalveolar lavage (BAL), and reduced BAL cell count and nitrogen oxide production. Additionally, 1400 W inhibited the formation of S-nitrosylated SP-D (SNO-SP-D) and the structural disruption of SP-D.	Free Radic Biol Med. 2016 Feb;91:293-301
Sprague Dawley rats	DFP-induced long-term neurotoxicity model	Intramuscular	20 mg/kg	Twice daily for the first three days	1400W significantly reduced DFP-induced iNOS and 3-NT upregulation in the hippocampus and piriform cortex, and the serum nitrite levels at 24h post-exposure. 1400W also prevented DFP-induced mortality in <24h. The brain immunohistochemistry (IHC) at 7d post-exposure revealed a significant reduction in gliosis and neurodegeneration (NeuN+ FJB positive cells) in the 1400W-treated group. 1400W, in contrast to the vehicle, caused a significant reduction in the epileptiform spiking and spontaneous recurrent seizures (SRS) during 12 weeks of continuous video-EEG study.	Neurobiol Dis. 2020 Jan;133:104443.
Sprague Dawley rats	Rat soman (GD) model of epilepsy	Intramuscular injection	20 mg/kg	Once daily for 2 weeks	1400W significantly reduced GD-induced motor and cognitive dysfunction; reduced nitrooxidative stress (nitrite, ROS; increased GSH:GSSG ratio); reduced proinflammatory cytokines in serum and cerebrospinal fluid (CSF); reduced epileptiform spikes and spontaneously recurring seizures (SRS) in males; reduced neuroinflammatory markers (GFAP + C3 and IBA1 + CD68-positive glia) and neurodegeneration (especially parvalbumin-positive neurons) in some brain regions.	J Neuroinflammation. 2023 Jul 12;20(1):163
Mice	Obesity model induced by high-fat high-sucrose diet	Implanted osmotic pump	30 mg/kg/day	Continued for 8 weeks	Reversed established CMD and oxidative stress, and preserved systolic/diastolic function in mice	JACC Basic Transl Sci. 2023 Feb 1;8(5):501-514
MRL/mpj mice	Autoimmune disease model	Intraperitoneal injection	5 mg/kg	Once daily, starting the day before SEB instillation and continuing throughout the experiment	1400W significantly inhibited lipid radical production in the lung, reduced the number of macrophages and neutrophils in BAL fluid, and alleviated inflammatory cell infiltration and collagen fiber synthesis in lung tissue.	Free Radic Biol Med. 2009 Aug 1;47(3):241-9

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CAS No.: 214358-33-5

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CAS No.: 214358-33-5

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed