1403836-23-6|Ethyl 1-cyclopropyl-6-fluoro-8-methoxy-7-(octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate| Ambeed

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CAS No. :	1403836-23-6
Formula :	C₂₃H₂₈FN₃O₄
M.W :	429.48
SMILES Code :	O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N(C4)CC5C4CCCN5)=C3OC)C1=O)OCC
MDL No. :	N/A

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319
Precautionary Statements:	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Yield	Reaction Conditions	Operation in experiment
		Under nitrogen protection,A solution of 1.1 g (40 mmol) of CuCl,(110 mmol) of ethylene glycol,Isobutylamine (12.4 g, 170 mmol)And 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline-carboxylate 32.3g (100mmol)Was charged into a reaction vessel equipped with 320 mL of methanol,The reaction was carried out at 50 C for 3 hours,The temperature was then raised to 68 C,(S, S) -2,8-diazabicyclo [4.3.0] nonane 13.9 g (110 mmol)The reaction was continued for 4 hours,The insoluble matter was filtered off by hot filtration (temperature: 58 C)Concentrated hydrochloric acid was added dropwise at room temperature,Adjust the pH to 2,Stirring for 2 hours after cooling to -5 crystallization,Filtration,Cold ethanol washing,Vacuum drying,Moxifloxacin hydrochloride as a white solid (40.7 g)The yield was 93.0%Purity 99.82% (HPLC area normalization method).
	With aluminum (III) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 60℃; for 3h;	In a 2L four-necked flask, the addition of a cyclohexyl ester100g (0.309mol),(S,S)-2,8-diazabicyclo[4,3,0]decane 40.5g (0.321mol),1000ml of acetonitrile, stirred, and charged with triethylamine 32.5 g (0.321 mol), AlCl3 2.05 g (0.015 mol),The temperature is raised to 60 C, and the heat preservation reaction is about 3 h.The system is basically clarified, sampled, TLC (developing agent is methanol:acetone:Ammonia = 15:5:3) Detection of traces of substantially unreacted starting material (additional cycloester),Cool to room temperature, filter, and continue to warm the filtrate to 50 C.Adding L-(+)-tartaric acid to 27.84 g (0.185 mol),Stirring for about 2 hours,The system is largely precipitated, cooled to 0-5 C, filtered,The filter cake was washed with acetonitrile and the filter cake was collected.Dry at 50-80 C under vacuum to constant weight, collect powder,Obtained 142g of moxifloxacin ethyl ester tartrate.The molar yield is 91.0% (calculated as the ratio of moxifloxacin ethyl ester to tartaric acid of 2:1),The substance has a purity of 99.82% and an optical isomer content of 0.08%.

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Disposal
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P501	Dispose of contents/container to ...
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CAS No.: 1403836-23-6

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CAS No.: 1403836-23-6

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[ 1403836-23-6 ] Synthesis Path-Upstream 1~1

[ 1403836-23-6 ] Synthesis Path-Downstream 1~1

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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
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H220	Extremely flammable gas
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H226	Flammable liquid and vapour
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
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H261	In contact with water releases flammable gas
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