Home Cart 0 Sign in  

[ CAS No. 1408087-64-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1408087-64-8
Chemical Structure| 1408087-64-8
Structure of 1408087-64-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 1408087-64-8 ]

Related Doc. of [ 1408087-64-8 ]

Alternatived Products of [ 1408087-64-8 ]

Product Details of [ 1408087-64-8 ]

CAS No. :1408087-64-8 MDL No. :MFCD28502396
Formula : C14H14FN5O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 287.29 Pubchem ID :-
Synonyms :

Safety of [ 1408087-64-8 ]

Signal Word:Warning Class:
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 UN#:
Hazard Statements:H315-H319 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 1408087-64-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1408087-64-8 ]
  • Downstream synthetic route of [ 1408087-64-8 ]

[ 1408087-64-8 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 1408087-64-8 ]
  • [ 1532533-67-7 ]
YieldReaction ConditionsOperation in experiment
20%
Stage #1: With triphenylphosphine In tetrahydrofuran at 25 - 28℃; for 0.0833333 h; Reflux
Stage #2: With di-isopropyl azodicarboxylate In tetrahydrofuran at 45℃; for 2 h;
(S)-2-(l-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-lH-pyrazolo[3,4-d]pyrimidin-l- yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one: To a solution of intermediate 13 (0.134 g, 0.494 mmol) in THF (2.0 ml), intermediate 5 (0.150 g, 0.494 mmol) and triphenylphosphine (0.194 g, 0.741 mml) were added and stirred at RT for 5 min. Diisopropylazodicarboxylate ( 0.15 ml, 0.749 mmol) was added heated to 45°C. After 2h, the reaction mixture was quenched with with water and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure. The crude product was purified by column chromatography with ethyl acetate : petroleum ether to afford the title compound as an off-white solid (0.049 g, 20 percent). MP: 139- 142°C. Mass : 571.7 (M H-NMR (δ ppm, CDC13, 400 MHz): 8.24 (s, 1H), 7.85 (dd, J = 8.2,3.1 Hz, 1H), 7.50-7.29 (m, 5H), 7.14 (t, J = 8.4 Hz, 1H), 7.02 (m, 2H), 6.92 (d, J = 8.4 Hz, 1H), 6.11 (q, J = 7.1 Hz, 1H), 5.40 (s, 2H), 4.66 (quintet, J = 6.1 Hz, 1H), 2.00 (d, J = 7.1Hz, 3H), 1.42 (d, J = 6.1 Hz, 6H). Enantiomeric excess: 89.8percent as determined by HPLC on a chiralpak AD-H column, enriched in the fast eluting isomer (retention time = 10.64min.).
Reference: [1] Patent: WO2014/6572, 2014, A1, . Location in patent: Paragraph 127
  • 2
  • [ 1408087-64-8 ]
  • [ 1532533-67-7 ]
  • [ 1532533-69-9 ]
YieldReaction ConditionsOperation in experiment
89.8 % ee With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 45℃; for 2 h; To a solution of intermediate 9 (0.134 g, 0.494 mmol) in THF (2.0 ml), intermediate 6 (0.150 g, 0.494 mmol) and triphenylphosphine (0.194 g, 0.741 mml) were added and stirred at RT for 5 min.
Diisopropylazodicarboxylate (0.15 ml, 0.749 mmol) was added heated to 45° C.
After 2 hours, the reaction mixture was quenched with water and extracted with ethyl acetate.
The organic layer was dried over sodium sulphate and concentrated under reduced pressure.
The crude product was purified by column chromatography with ethyl acetate:petroleum ether to afford the title compound as an off-white solid (0.049 g, 20percent yield). MP: 139-142° C. Mass: 571.7 (M+).
Enantiomeric excess:
89.8percent as determined by HPLC on a chiralpak AD-H column, enriched in the fast eluting isomer (retention time=10.64 min.).
Reference: [1] Patent: US2015/290317, 2015, A1, . Location in patent: Paragraph 0280
Same Skeleton Products
Historical Records