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[ CAS No. 141-84-4 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 141-84-4
Chemical Structure| 141-84-4
Chemical Structure| 141-84-4
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Product Details of [ 141-84-4 ]

CAS No. :141-84-4 MDL No. :MFCD00005488
Formula : C3H3NOS2 Boiling Point : -
Linear Structure Formula :- InChI Key :KIWUVOGUEXMXSV-UHFFFAOYSA-N
M.W : 133.19 Pubchem ID :1201546
Synonyms :

Safety of [ 141-84-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P301+P312+P330-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 141-84-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 141-84-4 ]
  • Downstream synthetic route of [ 141-84-4 ]

[ 141-84-4 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 110-91-8 ]
  • [ 1452-77-3 ]
  • [ 141-84-4 ]
  • [ 5346-38-3 ]
  • [ 16781-67-2 ]
YieldReaction ConditionsOperation in experiment
81% With MCM-41 mesoporous silica In ethanol; water at 80 - 90℃; for 9 h; Green chemistry General procedure: In a typical reaction a solution of amide (1 mmol), rhodanine (1.2 mmol) and Morpholine (1.2 mmol) in EtOH/water (2 + 2 ml) were refluxed at 80-90 °C till completion using 40 mg of MCM-41 catalyst. The completion of the reaction was indicated by the disappearance of the starting material in thin layer chromatography. After completion of the reaction the solvent was evaporated in a rotary evaporator and the crude product was taken in dichloromethane and filtered to separate the products as filtrate from the catalyst (residue). Then the crude product was purified by silica gel column chromatography where the compound (5) came out from the column with 25percentEtOAc/75percent petroleum ether, but thioamide (4) came out with 65percentEtOAc/35percent petroleum ether making their separation easy. The thioamides (4) were characterized by IR, 1H NMR, 13C NMR, CHN and X-ray single crystal analysis.
Reference: [1] Tetrahedron Letters, 2013, vol. 54, # 17, p. 2164 - 2170
  • 2
  • [ 110-91-8 ]
  • [ 872-50-4 ]
  • [ 141-84-4 ]
  • [ 16781-67-2 ]
  • [ 10441-57-3 ]
YieldReaction ConditionsOperation in experiment
75% With MCM-41 mesoporous silica In ethanol; water at 80 - 90℃; for 8 h; Green chemistry General procedure: In a typical reaction a solution of amide (1 mmol), rhodanine (1.2 mmol) and Morpholine (1.2 mmol) in EtOH/water (2 + 2 ml) were refluxed at 80-90 °C till completion using 40 mg of MCM-41 catalyst. The completion of the reaction was indicated by the disappearance of the starting material in thin layer chromatography. After completion of the reaction the solvent was evaporated in a rotary evaporator and the crude product was taken in dichloromethane and filtered to separate the products as filtrate from the catalyst (residue). Then the crude product was purified by silica gel column chromatography where the compound (5) came out from the column with 25percentEtOAc/75percent petroleum ether, but thioamide (4) came out with 65percentEtOAc/35percent petroleum ether making their separation easy. The thioamides (4) were characterized by IR, 1H NMR, 13C NMR, CHN and X-ray single crystal analysis.
Reference: [1] Tetrahedron Letters, 2013, vol. 54, # 17, p. 2164 - 2170
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