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Chemical Structure| 141-84-4 Chemical Structure| 141-84-4

Structure of Rhodanine
CAS No.: 141-84-4

Chemical Structure| 141-84-4

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Product Details of [ 141-84-4 ]

CAS No. :141-84-4
Formula : C3H3NOS2
M.W : 133.19
SMILES Code : O=C1CSC(=S)N1
MDL No. :MFCD00005488
InChI Key :KIWUVOGUEXMXSV-UHFFFAOYSA-N
Pubchem ID :1201546

Safety of [ 141-84-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P301+P312+P330-P305+P351+P338

Application In Synthesis of [ 141-84-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 141-84-4 ]

[ 141-84-4 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 141-84-4 ]
  • [ 14615-72-6 ]
  • C24H19NO3S2 [ No CAS ]
  • 2
  • [ 141-84-4 ]
  • [ 56442-17-2 ]
  • [ 247566-73-0 ]
YieldReaction ConditionsOperation in experiment
91.15% With sodium acetate; In acetic acid; for 7h;Reflux; To a stirred solution of 4-(4-Fluoro-benzyloxy)-benzaldehyde (250 mg, 1.09 mmol) , rhodanine (145 mg., 1.09 mmol) in acetic acid (10 ml) was added sodium acetate (357 mg, 4.36 mmol) and heated under reflux for 7 h . After cooling to room temperature, water (15ml) was added and solid precipitate was filtered ,washed with water (10ml) and hexane(10 ml) and dried under vacuum to afford a yellow solid product (340 mg , 91.15%).
  • 3
  • [ 141-84-4 ]
  • [ 689291-89-2 ]
  • 5-(5-bromo-2-iodobenzylidene)-2-thioxothiazolidin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With sodium hydroxide; In ethanol;Reflux; General procedure: The 2-thioxo-4-thiazolidinone (1mmol), benzaldehydes (1 mmol) and NaOH (1.0 mmol) were added to ethanol withtotal volume of 15 mL. The reaction mixture was heated to reflux and stirredfor 2-24 h. After cooling to room temperature, the mixture was concentrated under reduced pressure, neutralized to pH 7.0 with dilute hydrochloric, and then extracted with ethyl acetate (3×100 mL). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, and concentrated. The resulting residue was recrystallization from ethanol.
  • 4
  • [ 141-84-4 ]
  • [ 19415-51-1 ]
  • 5-(5-fluoro-2-methoxybenzylidene)-2-thioxothiazolidin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With sodium hydroxide; In ethanol;Reflux; General procedure: The 2-thioxo-4-thiazolidinone (1mmol), benzaldehydes (1 mmol) and NaOH (1.0 mmol) were added to ethanol withtotal volume of 15 mL. The reaction mixture was heated to reflux and stirredfor 2-24 h. After cooling to room temperature, the mixture was concentrated under reduced pressure, neutralized to pH 7.0 with dilute hydrochloric, and then extracted with ethyl acetate (3×100 mL). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, and concentrated. The resulting residue was recrystallization from ethanol.
  • 5
  • [ 141-84-4 ]
  • [ 90176-80-0 ]
  • 5-(4-fluoro-2-(trifluoromethyl)benzylidene)-2-thioxothiazolidin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
81% With sodium hydroxide; In ethanol;Reflux; General procedure: The 2-thioxo-4-thiazolidinone (1mmol), benzaldehydes (1 mmol) and NaOH (1.0 mmol) were added to ethanol withtotal volume of 15 mL. The reaction mixture was heated to reflux and stirredfor 2-24 h. After cooling to room temperature, the mixture was concentrated under reduced pressure, neutralized to pH 7.0 with dilute hydrochloric, and then extracted with ethyl acetate (3×100 mL). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, and concentrated. The resulting residue was recrystallization from ethanol.
 

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Related Functional Groups of
[ 141-84-4 ]

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[ 141-84-4 ]

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