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Chemical Structure| 1423018-14-7 Chemical Structure| 1423018-14-7

Structure of 1423018-14-7

Chemical Structure| 1423018-14-7

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Product Details of [ 1423018-14-7 ]

CAS No. :1423018-14-7
Formula : C17H19NO3S
M.W : 317.40
SMILES Code : O=C(C1=CC=C(CN2CCCC3=C2C(OC)=CC=C3)S1)OC

Safety of [ 1423018-14-7 ]

Application In Synthesis of [ 1423018-14-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1423018-14-7 ]

[ 1423018-14-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 53899-17-5 ]
  • [ 108499-32-7 ]
  • [ 1423018-14-7 ]
YieldReaction ConditionsOperation in experiment
56% With N-ethyl-N,N-diisopropylamine; In ethanol; at 20℃; Add methyl-5-(bromoethyl)thiophene-2-carboxylate (432.5 g, 1.84 mol) in EtOH (500 ml) to a solution of 8-methoxy-l,2,3,4-tetrahydroquinoline (300 g 1.84 mol) in EtOH (1 L) and stir. Add DIPEA (641 ml, 3.67 mol) dropwise and stir at room temperature overnight. After completion of the reaction, remove the EtOH in vacuo, and add water (5 L). Extract the aqueous with EtOAc (3 x 3 L); combine the organic layers; and dry over sodium sulfate. Filter the solution and concentrate under reduced pressure to give a residue. Purify the residue by silica gel flash chromatography eluting with ethyl acetate: hexane (6:94) to give the title compound (325 g, 56%). ESI (m/z) 318(M+H).
  • 2
  • 8-methoxy-1,2,3,4-tetrahydroquinoline hydrochloride [ No CAS ]
  • [ 108499-32-7 ]
  • [ 1423018-14-7 ]
 

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