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Chemical Structure| 1427446-94-3 Chemical Structure| 1427446-94-3

Structure of 1427446-94-3

Chemical Structure| 1427446-94-3

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Product Details of [ 1427446-94-3 ]

CAS No. :1427446-94-3
Formula : C8H5Br2FO
M.W : 295.93
SMILES Code : O=C(C1=CC(F)=CC=C1Br)CBr
MDL No. :MFCD23711741

Safety of [ 1427446-94-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P260-P264-P280-P301+P310+P330+P331-P303+P361+P353+P310-P304+P340+P310-P305+P351+P338+P310-P363-P405-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 1427446-94-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1427446-94-3 ]

[ 1427446-94-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1006-33-3 ]
  • [ 1427446-94-3 ]
YieldReaction ConditionsOperation in experiment
With hydrogen bromide; bromine; In diethyl ether; water; at 0 - 20℃; for 2h; To a stirred solution of <strong>[1006-33-3]1-(2-bromo-5-fluorophenyl)ethanone</strong> (5 g, 23.04 mmol) and HBr (48percent w/w aqueous, 0.2 mL, 1.768 mmol) in diethyl ether (50 mL) at 0°C was added bromine (1.2 mL, 23.29 mmol) dropwise. The mixture was stirred at rt for 2 h. It was transferred into a separatory funnel and washed with water (50 mL). The aqueous layer was extracted with diethyl ether (100 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated. The residue was purified by flash column chromatography on silica gel (eluting with 0-20percent ethyl acetate in hexane) to give the title compound.
 

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