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Chemical Structure| 1427565-04-5 Chemical Structure| 1427565-04-5

Structure of 1427565-04-5

Chemical Structure| 1427565-04-5

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Product Details of [ 1427565-04-5 ]

CAS No. :1427565-04-5
Formula : C8H6Br2O
M.W : 277.94
SMILES Code : O=CC1=C(C)C=C(Br)C=C1Br
MDL No. :MFCD32632793

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Application In Synthesis of [ 1427565-04-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1427565-04-5 ]

[ 1427565-04-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24078-12-4 ]
  • [ 1427565-04-5 ]
YieldReaction ConditionsOperation in experiment
69% With N-Bromosuccinimide; 4-chloro-2-(trifluoromethyl)aniline; palladium diacetate; In 1,2-dichloro-ethane; trifluoroacetic acid; at 60℃; for 24h; General procedure: Compound 1 (0.4 mol), N-bromosuccinimide (NBS) (0.48 mol, 85.4 mg), and Pd(OAc)2(10 mol%, 8.9 mg), 2-Amino-5-chlorobenzotrifluoride (20 mol%, 15.6 mg) were mixed withDCE (2.5 mL) and TFA (0.5 mL) solvent. The reaction mixture was stirred 24 h at 60 C. Aftercompletion of the reaction, the solution was concentrated in vacuo and purified by columnchromatography on silica gel using PE/DCM/EtOAc as eluent to give the desired product.
 

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