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Chemical Structure| 1429629-67-3 Chemical Structure| 1429629-67-3

Structure of 1429629-67-3

Chemical Structure| 1429629-67-3

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Product Details of [ 1429629-67-3 ]

CAS No. :1429629-67-3
Formula : C7H5ClN2OS
M.W : 200.65
SMILES Code : O=C1C2=C(C=C(C)S2)N=C(Cl)N1

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Application In Synthesis of [ 1429629-67-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1429629-67-3 ]

[ 1429629-67-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 35265-82-8 ]
  • [ 1429629-67-3 ]
YieldReaction ConditionsOperation in experiment
92% With water; sodium hydroxide; In tetrahydrofuran; at 20℃;Inert atmosphere; Step 1. Preparation of 2-Chloro-6-methylthieno[3,2-d]pyrimidin-4(3H)-oneA mixture of <strong>[35265-82-8]2,4-dichloro-6-methylthieno[3,2-d]pyrimidine</strong> (450 mg, 2.05 mmol), aqueous NaOH (IN, 4 mL) and THF (4 mL) was stirred at room temperature under N2. The reaction was monitored by HPLC until the reaction was completed. Then the mixture was neutralized to PH 5 by addition of 2N aqueous HC1. The solid was filtrated and dried to give 380 mg of 2-chloro-6- methylthieno[3,2-d]pyrimidin-4(3H)-one (yield was 92%) as a yellow solid. MS obsd. (ESI ) [(M+H)+]: 201.
  • 2
  • [ 35265-82-8 ]
  • [ 1429629-67-3 ]
YieldReaction ConditionsOperation in experiment
92% With water; sodium hydroxide; In tetrahydrofuran; at 20℃;Inert atmosphere; A mixture of <strong>[35265-82-8]2,4-dichloro-6-methylthieno[3,2-d]pyrimidine</strong> (450 mg, 2.05 mmol), aqueous NaOH (1N, 4 mL) and THF (4 mL) was stirred at room temperature under N2. The reaction was monitored by HPLC until the reaction was completed. Then the mixture was neutralized to PH 5 by addition of 2N aqueous HCl. The solid was filtrated and dried to give 380 mg of 2-chloro-6-methylthieno[3,2-d]pyrimidin-4(3H)-one (yield was 92%) as a yellow solid. MS obsd. (ESI+) [(M+H)+]: 201.
 

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