CAS No. :	143-07-7
Formula :	C₁₂H₂₄O₂
M.W :	200.32
SMILES Code :	CCCCCCCCCCCC(O)=O
Synonyms :	Dodecanoic acid; Dodecylic acid; GT-08
MDL No. :	MFCD00002736
InChI Key :	POULHZVOKOAJMA-UHFFFAOYSA-N
Pubchem ID :	3893

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H318-H410
Precautionary Statements:	P273-P280-P305+P351+P338+P310-P501
Class:	9
UN#:	3077
Packing Group:	Ⅲ

CHL cells	27.40 ± 12.78 μM	50 ms	To investigate the inhibitory effect of lauric acid on Na V1.5 channel, results showed that lauric acid dose-dependently inhibited Na V1.5 current.	Drug Des Devel Ther. 2025 Jan 9;19:141-157
Mouse primary hepatocytes	0.5 mmol/L	24 hours	To investigate the effect of lauric acid on HNF4α and p38 MAPK signaling pathways, results showed that lauric acid stimulation significantly increased the phosphorylation levels of HNF4α and p38 MAPK.	EMBO J. 2024 Feb;43(4):507-532
hiPSC-derived cardiomyocytes	1 mM to 100 nM	30 s	To evaluate the effect of lauric acid on hiPSC-CMs, results showed that lauric acid reduced EFP amplitude.	Drug Des Devel Ther. 2025 Jan 9;19:141-157
Staphylococcus aureus	1024 µg/mL	24 hours	To evaluate the antagonistic effect of lauric acid in combination with oxacillin against Staphylococcus aureus. Results showed that lauric acid at 1024 µg/mL in combination with oxacillin exhibited antagonistic action with fractional inhibitory concentration indices (FICI) ranging from 4.01 to 4.28.	Sci Rep. 2021 Jan 8;11(1):177
H9c2 rat cardiomyoblasts	40 μg/mL		In the in vitro cachexia model, combined treatment with LAA and high glucose restored mitochondrial respiration and glycolysis, ATP to control levels, and reduced oxidative stress	Cancer Sci. 2020 Dec;111(12):4605-4615
HT29 colon cancer cells	40 µg/mL	48 hours	Lauric acid suppressed HT29 cell proliferation, induced mitochondrial oxidative stress (ROS), inhibited oxidative phosphorylation (OXPHOS), and induced apoptosis.	Int J Mol Sci. 2025 Feb 24;26(5):1953
CT26 colon cancer cells	40 µg/mL	48 hours	Lauric acid suppressed CT26 cell proliferation, induced mitochondrial oxidative stress (ROS), inhibited oxidative phosphorylation (OXPHOS), and induced apoptosis.	Int J Mol Sci. 2025 Feb 24;26(5):1953
CT26 cells	40 µg/mL	48 hours	Lauric acid reversed 5FU resistance by inducing OXPHOS, increasing ROS levels, and inducing cell death.	Int J Mol Sci. 2025 Jan 14;26(2):664
HT29 cells	40 µg/mL	48 hours	Lauric acid reversed 5FU resistance by inducing OXPHOS, increasing ROS levels, and inducing cell death.	Int J Mol Sci. 2025 Jan 14;26(2):664

Drosophila melanogaster	Α-synuclein transgenic Parkinson's disease model	Dietary administration	250 mg/kg diet	21 days	Lauric acid (LA) alone or in combination with levodopa (LD) significantly improved Parkinson's disease-like features in the transgenic Drosophila model by modulating neurobehavioral activities, reducing oxidative stress, and regulating apoptotic and inflammatory processes.	Brain Behav. 2024 Sep;14(9):e70001
BALB/c mice	Cachexia model	Oral	2% (w/w)	Free intake	LAA alone did not significantly improve myocardial atrophy, but combined administration with glucose restored myocardial atrophy and MYL1 to control levels	Cancer Sci. 2020 Dec;111(12):4605-4615
BALB/c mice	CT26 peritoneal dissemination model	Oral	2% (w/w) diet	Daily administration for two weeks	Lauric acid significantly reduced tumor weight and ascites volume, increased the number of effector T cells, and enhanced antitumor immune responses.	Int J Mol Sci. 2025 Feb 24;26(5):1953
BALB/c mice	CT26 mouse cachexia model	Oral	2% w/w	15 days	The C8 diet showed a greater effect on improving myocardial damage compared with C10 and C12 diets. C8 restored approximately 10% of heart weight and improved cardiomyocyte area and myocardial lipid peroxidation.	Int J Mol Sci. 2024 Jul 24;25(15):8081

NCT01826422	Muscular Dystrophy, Duchenne	Not Applicable	Completed	-	Mexico ... More >> Unit of Medical Researcha in Nutrition, Pediatric Hospital, IMSS. Mexico city, Mexico, 06720 Less <<
NCT01826422	-		Completed	-	-
NCT01996566	-		Completed	-	United States, Indiana ... More >> Purdue University West Lafayette, Indiana, United States, 47907 Less <<
NCT02800538	Healthy Volunteers	Not Applicable	Completed	-	Belgium ... More >> University Hospitals Leuven, campus Gasthuisberg Leuven, Belgium, 3000 Less <<
NCT00439582	Cardiovascular Disease	Not Applicable	Completed	-	France ... More >> Centre de Recherche en Nutrition Humaine (CRNH), UEN, Laboratoire de Nutrition Humaine Clermont-Ferrand, France, 63009 Less <<
NCT02883751	Diabetes Mellitus ... More >> Amputation Stumps Diabetic Foot Less <<	Not Applicable	Unknown	December 2018	Brazil ... More >> Universidade Nove de Julho São Paulo, SP, Brazil, 01504015 Less <<
NCT00843466	Hand Dermatosis	Not Applicable	Completed	-	United States, North Carolina ... More >> Wake Forest University Health Sciences Dermatology Winston-Salem, North Carolina, United States, 27157 Less <<
NCT02982616	Healthy Volunteers	Not Applicable	Completed	-	Belgium ... More >> University Hospitals Leuven, campus Gasthuisberg Leuven, Belgium, 3000 Less <<
NCT00843466	-		Completed	-	-
NCT02809235	Asthma	Not Applicable	Not yet recruiting	July 2018	United States, Massachusetts ... More >> Asthma Research Center, Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Less <<
NCT01962844	Chronic Coronary Artery Diseas... More >>e Less <<	Not Applicable	Unknown	March 2014	Brazil ... More >> Instituto Nacional do Coração Rio de Janeiro, Brazil, 22240-002 Less <<
NCT02984150	Healthy Volunteers	Not Applicable	Completed	-	Belgium ... More >> University Hospitals Leuven, campus Gasthuisberg Leuven, Belgium, 3000 Less <<
NCT01109381	Helicobacter Pylori Infection	Phase 1 Phase 2	Terminated(Poor efficacy (2 of... More >> 31 completing participants with H.pylori eradication)) Less <<	-	Singapore ... More >> Singapore General Hospital Singapore, Singapore Less <<
NCT01109381	-		Terminated(Poor efficacy (2 of... More >> 31 completing participants with H.pylori eradication)) Less <<	-	-
NCT03481608	Diet Modification	Not Applicable	Completed	-	United States, New York ... More >> Human Metabolic Research Unit, Cornell University Ithaca, New York, United States, 14853 Less <<

{[proInfo.proName]}

CAS No.: 143-07-7

{[proInfo.proName]}

CAS No.: 143-07-7

Alternative Products

Product Details of Lauric Acid

Safety of Lauric Acid

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed