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Chemical Structure| 1431412-39-3 Chemical Structure| 1431412-39-3

Structure of 1431412-39-3

Chemical Structure| 1431412-39-3

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Product Details of [ 1431412-39-3 ]

CAS No. :1431412-39-3
Formula : C8H5ClN2O2S
M.W : 228.65
SMILES Code : O=C(O)C1=C(C2=NC=NC(Cl)=C2S1)C
MDL No. :MFCD28964771

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Application In Synthesis of [ 1431412-39-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1431412-39-3 ]

[ 1431412-39-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 124-38-9 ]
  • [ 175137-21-0 ]
  • [ 1431412-39-3 ]
YieldReaction ConditionsOperation in experiment
88% A solution of diisopropylamine (2.71 mL, 0.0193 mol) in dry THF (70 mL) was cooled to-78 C. A solution of n-butyllithium (2.5 M) in hexanes was added to this reaction mixturedropwise. After stirring for 30 minutes at -78 C, the mixture was added dropwise via syringe to a stirring suspension of 4-chloro-7-methylthieno [3 ,2-d]pyrimidine (Compound 113; 2.5 g, 0.0 135 mol) in THF at -78C. The suspension became homogenous when the addition was complete. The mixture was kept at -78 C for 45 minutes and then CO2 gas was bubbled through the reaction mixture for 10 minutes causing the green color todisappear. The reaction was kept under dry nitrogen gas and allowed to warm to room temperature overnight. The mixture was concentrated under reduced pressure and then THF was added, the mixture stirred for 1 hour and then filtered. The collected solid was suspended in dilute aqueous HC1, stirred, collected and washed with dilute aqueous HC1. The resulting beige solid was dried overnight under vacuum to obtain <strong>[175137-21-0]4-chloro-7-methylthieno[3,2-d]pyrimidine</strong>-6-carboxylic acid (Compound 114; 2.71 g, 88%). MS(ESI) calcd for C8H5C1N2025: 227.98; found: 229 [M+H].
 

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