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Chemical Structure| 1445877-16-6 Chemical Structure| 1445877-16-6

Structure of 1445877-16-6

Chemical Structure| 1445877-16-6

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Product Details of [ 1445877-16-6 ]

CAS No. :1445877-16-6
Formula : C10H11N3O5
M.W : 253.21
SMILES Code : O=C(O)C1=C([N+]([O-])=O)C=NC(N2CCOCC2)=C1

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Application In Synthesis of [ 1445877-16-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1445877-16-6 ]

[ 1445877-16-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-91-8 ]
  • [ 907545-47-5 ]
  • [ 1445877-16-6 ]
YieldReaction ConditionsOperation in experiment
76% With potassium carbonate; at 100℃; for 4h; A mixture of <strong>[907545-47-5]2-chloro-5-nitroisonicotinic acid</strong> (28.5 g, 141 mmol), morpholine (36.8 g,423 mmol) and k2CO3 (58.4 g, 423 mmol) was stirred at 100 °C for 4h. The mixture wascooled to room temperature and poured into water (1.5 L). It was acidified with 4N HCl to pH=1 and extracted with EA (1 L X 3). The combined organic layers were washed with brine (1 L X 5), then dried over anhydrous Na2SO4, filtered and concentrated in vacuo to afford the desired product as a yellow solid (27 g, 76percent); LC/MS: MS(ES) m/e 254(MH+); 1H NMR (300 MHz, DMSO-d6) delta ppm 3.68 (t, J=4.8 Hz, 1 H), 3.77 (t, J=4.8 Hz, 4 H), 6.99 (s, 1H), 8.91 (s, 1H).
 

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