Alternatived Products of [ 1454585-06-8 ]
Product Details of [ 1454585-06-8 ]
CAS No. : | 1454585-06-8 |
MDL No. : | MFCD30187527 |
Formula : |
C23H19F3N8O
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | CEBMEQPREMCWOL-UHFFFAOYSA-N |
M.W : |
480.45
|
Pubchem ID : | 60196195 |
Synonyms : |
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Safety of [ 1454585-06-8 ]
Application In Synthesis of [ 1454585-06-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1454585-06-8 ]
- 1
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[ 153505-39-6 ]
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[ 1454585-06-8 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1.1: ethylene dichloride hydrochloride; 1-hydroxybenzotriazol-hydrate / dichloromethane / 0.17 h / 20 °C / Inert atmosphere
1.2: 23 °C / Inert atmosphere
1.3: 2 h / 70 °C / Inert atmosphere
2.1: hydrogenchloride / water; 1,4-dioxane / 23 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere
3.2: 1 h / 100 °C / Microwave irradiation; Inert atmosphere |
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Multi-step reaction with 4 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.17 h / 20 °C
1.2: 20 °C
1.3: 2 h / 70 °C
2.1: hydrogenchloride / water; 1,4-dioxane / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.5 h / 90 °C / Sealed tube; Microwave irradiation
4.1: 1 h / 100 °C / Sealed tube |
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Multi-step reaction with 3 steps
1.1: 4-methyl-morpholine / tetrahydrofuran / 1 h / 0 °C
1.2: 2 h / 70 °C
2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.5 h / 90 °C / Microwave irradiation; Sealed tube
3.1: 0.5 h / 130 °C / Microwave irradiation; Sealed tube |
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Reference:
[1]Bibian, Mathieu; Rahaim, Ronald J.; Choi, Jun Yong; Noguchi, Yoshihiko; Schürer, Stephan; Chen, Weimin; Nakanishi, Shima; Licht, Konstantin; Rosenberg, Laura H.; Li, Lin; Feng, Yangbo; Cameron, Michael D.; Duckett, Derek R.; Cleveland, John L.; Roush, William R.
[Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 15, p. 4374 - 4380]
[2]Current Patent Assignee: STATE UNIVERSITY SYSTEM OF FLORIDA - WO2013/130461, 2013, A1
[3]Monastyrskyi, Andrii; Nilchan, Napon; Quereda, Victor; Noguchi, Yoshihiko; Ruiz, Claudia; Grant, Wayne; Cameron, Michael; Duckett, Derek; Roush, William
[Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 3, p. 590 - 602]