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Chemical Structure| 145797-86-0 Chemical Structure| 145797-86-0

Structure of 145797-86-0

Chemical Structure| 145797-86-0

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Product Details of [ 145797-86-0 ]

CAS No. :145797-86-0
Formula : C11H12BrNO
M.W : 254.12
SMILES Code : O=C(N1CC2=C(C=CC=C2)CC1)CBr
MDL No. :MFCD15206027
InChI Key :IXTRPIUOVNEKRQ-UHFFFAOYSA-N
Pubchem ID :18467239

Safety of [ 145797-86-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331-H341
Precautionary Statements:P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 145797-86-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 145797-86-0 ]

[ 145797-86-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 35613-44-6 ]
  • [ 145797-86-0 ]
  • 2-(2-((2-(3,4-dihydroisoquinolin-2(1Η)-yl)-2-oxoethyl)amino)phenyl)methylacetate [ No CAS ]
YieldReaction ConditionsOperation in experiment
31% With potassium carbonate; In acetonitrile; at 80℃; for 5h; 2-bromo-1-(3,4-dihydroisoquinolin-2(1H)-yl)ethanone (370 mg, 1.45 mmol), <strong>[35613-44-6]methyl 2-(2-aminophenyl)acetate</strong> (200 mg, 1.21) Methyl, anhydrous potassium carbonate (500 mg, 3.63 mmol) was added to acetonitrile (10 mL) successively, and the mixture was stirred and warmed at 80 C for 5 hours.. The TLC monitors the end of the reaction. The reaction mixture was cooled to room temperature, and the mixture was evaporated to dryness. Purification by crude silica gel column chromatography (petrole ether / ethyl acetate = 4 / 1) afforded 2-(2-((2-(3,4-dihydroisoquinolin-2(1Eta)yl)-2-oxoethyl)amino)phenyl)methyl acetate(N-001) was obtained as a pale yellow oil (150 mg, 31%).
 

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