[ CAS No. 147403-52-9 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 147403-52-9
Chemical Structure| 147403-52-9
Structure of 147403-52-9

Quality Control of [ 147403-52-9 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 147403-52-9 ]

SDS

Product Details of [ 147403-52-9 ]

CAS No. :147403-52-9MDL No. :MFCD20527276
Formula :C26H22N4O5Boiling Point :-
Linear Structure Formula :-InChI Key :-
M.W :470.48Pubchem ID :15237011
Synonyms :

Computed Properties of [ 147403-52-9 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 147403-52-9 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 147403-52-9 ]

  • Downstream synthetic route of [ 147403-52-9 ]

[ 147403-52-9 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 80841-79-8 ]
  • [ 147403-52-9 ]
  • C31H26N4O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
79.1% Add 5g of [147403-52-9][147403-52-9]azilsartan methyl ester intermediate A4 to a 250ml round bottom flask. Potassium carbonate 3.0g, potassium iodide 0.4g, DMF 70mL, Cool to -10 to 0 ° C and stir for 0.5 hours. A solution of 1.9 g of 4-iodomethyl-5-methyl-1,3-dioxol-2-one in 30 mL of DMF was added dropwise to the above reaction system, and after heating, the temperature was raised to 40 ° C to react 2 to 4 hour. After the reaction is completed, add 200 mL of water. The pH was adjusted to 2 to 3 with dilute hydrochloric acid, filtered, and the residue was washed three times with water and dried. The crude product was purified by silica gel column chromatography. The eluent was dichloromethane-methanol (DCM: MeOH = 50:1). The product was obtained in an amount of 4.9 g, a yield of 79.1percent, and a purity of 96.4percent.
  • 2
  • [ 80715-22-6 ]
  • [ 147403-52-9 ]
  • C31H26N4O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
77.5% Into a 250 ml round bottom flask, 5 g of [147403-52-9][147403-52-9]azilsartan methyl ester intermediate A4, potassium carbonate 2.2 g, and DMF 70 mL were placed, and the mixture was cooled to -10 to 0 ° C and stirred for 0.5 hour. 2.1 g of 4-bromomethyl-5-methyl-1,3-dioxol-2-one in 30 mL of DMF was added dropwise to the above reaction system. After the addition is completed, the reaction is allowed to rise to room temperature for 2 to 4 hours. After the reaction was completed, 200 mL of water was added, and the pH was adjusted to 2 to 3 with dilute hydrochloric acid, and filtered, and the residue was washed three times with water and then dried.The crude product was purified by silica gel column chromatography.The eluent was dichloromethane-methanol (DCM: MeOH = 50:1).The product was obtained in an amount of 4.8 g, a yield of 77.5percent, and a purity of 97.1percent.
  • 3
  • [ 80841-78-7 ]
  • [ 147403-52-9 ]
  • C31H26N4O8 [ No CAS ]
YieldReaction ConditionsOperation in experiment
77.5% In a 250 ml round bottom flask, 5 g of [147403-52-9][147403-52-9]azilsartan methyl ester intermediate A4, potassium carbonate 2.2 g, potassium iodide 0.15 g, DMSO 70 mL, cooled to -10 to 0 ° C and stirred for 1 hour. A solution of 1.9 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one in 30 mL of DMSO was added dropwise to the above reaction system. After the addition is completed, the reaction is allowed to rise to room temperature for 2 to 4 hours. After the reaction was completed, 200 mL of water was added, and the pH was adjusted to 2 to 3 with dilute hydrochloric acid, and filtered, and the residue was washed three times with water and then dried. The crude product was purified by silica gel column chromatography. The eluent was dichloromethane-methanol (DCM: MeOH = 50:1). The product was obtained in an amount of 4.8 g, a yield of 77.5percent, and a purity of 96.2percent.
  • 4
  • [ 147403-52-9 ]
  • C35H28N4O11 [ No CAS ]
  • 5
  • C25H23N3O4 [ No CAS ]
  • [ 147403-52-9 ]
  • 6
  • methyl 1-[(2'-formylbiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate [ No CAS ]
  • [ 147403-52-9 ]
  • 7
  • [ 911314-60-8 ]
  • [ 147403-52-9 ]
  • 8
  • [ 150058-27-8 ]
  • [ 147403-52-9 ]
  • 9
  • [ 150058-27-8 ]
  • [ 147403-52-9 ]
  • 10
  • C25H22ClN3O4 [ No CAS ]
  • [ 67-64-1 ]
  • [ 147403-52-9 ]
YieldReaction ConditionsOperation in experiment
81% With potassium cyanate; at 20℃; for 12h; A 500 ml round bottom flask was added with 1-[(2'-chloro(formylhydrazino)biphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylic acid methyl ester (VI) (15.0 g, 32.3 mmol), potassium cyanate (3.9 g, 48.5 mmol) and anhydrous acetone (100 ml) were stirred at room temperature for 12 h.TLC detection reaction is complete. The reaction solution was poured into 200 ml of water, and a large amount of solids precipitated, which was filtered with suction and washed with a small amount of water to obtain 12.3 g of a white solid product with a yield of 81percent.
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