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Chemical Structure| 14903-78-7 Chemical Structure| 14903-78-7

Structure of 14903-78-7

Chemical Structure| 14903-78-7

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Product Details of [ 14903-78-7 ]

CAS No. :14903-78-7
Formula : C10H10N2
M.W : 158.20
SMILES Code : CC1=CC=C2C=CC(C)=NC2=N1
MDL No. :MFCD08753877
InChI Key :IVOPVBBXMWVCHV-UHFFFAOYSA-N
Pubchem ID :594113

Safety of [ 14903-78-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 14903-78-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 14903-78-7 ]

[ 14903-78-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1569-16-0 ]
  • [ 14903-78-7 ]
  • 2
  • [ 917-54-4 ]
  • [ 1569-16-0 ]
  • [ 14903-78-7 ]
YieldReaction ConditionsOperation in experiment
75% In the second step, <strong>[1569-16-0]2-methyl-1,8-naphthyridine</strong> (27 mmol, 3.8 g) was dissolved in diethyl ether (50 mL) under a nitrogen atmosphere, and then cooled to -78° C., and added dropwise with stirring (0.5 h increments). (b) Diethyl ether solution (20mL) of CH3-Li (32mmol, 1.6M, purchased from JV of BAHL Technology, Inc.), and then warmed to room temperature (25°C) and stirred for 12h. The reaction was quenched by adding 15mL of saturated aqueous ammonium chloride. The organic layer was separated and the aqueous layer was extracted with chloroform three times. The organic layers were combined and dried over anhydrous Na2SO4. The solvent was evaporated under reduced pressure to give an orange-red oil. KMnO4 (96 mmol, 15.2 g, purchased from Beijing Chemical Industry Plant) was added at room temperature. After stirring for 6 h at 25° C., the mixture was suction filtered, and the filtrate was evaporated under reduced pressure to obtain a crude solid product, which was further purified by column chromatography (petroleum ether/ethyl acetate mixture with a volume ratio of 100/1). A compound (known compound) having the structure represented by the formula (1-1) is obtained,The yield was 75percent.
 

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