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Chemical Structure| 149490-75-5 Chemical Structure| 149490-75-5

Structure of 149490-75-5

Chemical Structure| 149490-75-5

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Product Details of [ 149490-75-5 ]

CAS No. :149490-75-5
Formula : C11H14O3
M.W : 194.23
SMILES Code : CC(C)(C1=CC=CC(O)=C1)C(OC)=O
MDL No. :MFCD24713922

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Application In Synthesis of [ 149490-75-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 149490-75-5 ]

[ 149490-75-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 32454-33-4 ]
  • [ 149490-75-5 ]
YieldReaction ConditionsOperation in experiment
With boron tribromide; In dichloromethane; at -65℃; for 1.5h; Step B; 2-(3-Methoxy-phenyl)-2-methyl-propionic acid methyl ester 78 (2.77 g, 13.3 mmol) is dissolved in dry DCM (17 mL). The solution is cooled to -65C. boron tribromide (4.33 g, 17.3 mmol) dissolved in DCM (17 mL) is added. The reaction mixture is stirred at -650C for 90 min. Then the mixture is quenched with MeOH. Solvents are removed in vacuo, the remainder is diluted with ethyl acetate and washed with 0.2 N HCl. The aqueous phase is exrtacted with ethyl acetate. The organic layers are combined, washed with water and brine, dried over MgSO4, filtered and concentrated. Silica gel chromatography (0-25% ethyl acetate in hexanes) yielded 79 as a light yellow oil. 1H-NMR (400 MHz, CDCl3) delta = 7.25 (t, J= 8.0 Hz, IH)5 6.97-6.94 (m, IH), 6.88 (s, IH), 6.79-6.76 (m, IH), 3.72 (s, 3H), 1.62 (s, 6H); MS calcd. for CnHi4NaO3 (M+Na4) 217.1, found 217.1.
 

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