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Chemical Structure| 72719-84-7 Chemical Structure| 72719-84-7
Chemical Structure| 72719-84-7

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14:0 DAP is a key conponent of LNP as an effective delivery vehicle of mRNA.

4.5 *For Research Use Only !

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Product Details of 14:0 DAP

CAS No. :72719-84-7
Formula : C33H65NO4
M.W : 539.87
SMILES Code : O=C(CCCCCCCCCCCCC)OCC(CN(C)C)OC(CCCCCCCCCCCCC)=O

Safety of 14:0 DAP

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of 14:0 DAP

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72719-84-7 ]

[ 72719-84-7 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 623-57-4 ]
  • [ 112-64-1 ]
  • [ 72719-84-7 ]
YieldReaction ConditionsOperation in experiment
72% With pyridine;dmap; In dichloromethane; at 0 - 20℃; for 6h; To a mixture of 3-(dimethylamino)propane-l,2-diol (0.5g, 4.2mmoles), pyridine (1.7OmL, 21mmoles) and 4-dimethylaminopyridine (catalytic amount) in 1OmL of dry dichloromethane was added myristoyl chloride (2.6g, 10.5mmoles) at 0°C. The reaction was allowed to proceed from 00C to room temperature for 6 hours. The reaction mixture was extracted with chloroform (50 mL), washed with 5percent sodium bicarbonate (3x25 mL), followed by water (2x25 mL) and brine solution (2x25 mL). The chloroform extract was evaporated on a rotary evaporator and the residue was loaded on a silica gel (230-400 mesh), eluted with 0.2percent methanol in chloroform to afford a waxy white solidAnother batch of (+/-)-N,N-Dimethyl-N-[2,3-bis(tetradecanoyloxy)-propyl]amine was prepared, and yielded the following NMR spectra coordinates: 1H NMR (CDCl3): delta 5.24-5.15 (m, IH), 4.35 (dd, J= 12.0, 3.2 Hz, IH), 4.08 (dd, J= 11.6, 6.0 Hz, IH), 2.52-2.38 (m, 2H), 2.30 (dt, J= 7.2, 3.6 Hz, 4H), 2.61 (s, 6H), 1.67-1.53 (m, 4H), 1.36- 1.17 (m, 40H), 0.87 (t, J= 6.4 Hz, 6H).
 

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