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Chemical Structure| 1503991-64-7 Chemical Structure| 1503991-64-7

Structure of 1503991-64-7

Chemical Structure| 1503991-64-7

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Product Details of [ 1503991-64-7 ]

CAS No. :1503991-64-7
Formula : C8H9BrN2O
M.W : 229.07
SMILES Code : O=C(NN)C1=CC(C)=CC=C1Br
MDL No. :MFCD24050818

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Application In Synthesis of [ 1503991-64-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1503991-64-7 ]

[ 1503991-64-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6967-82-4 ]
  • [ 1503991-64-7 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; In methanol; for 2h;Reflux; General procedure: Substituted N'-acetyl-2-bromobenzohydrazides(1a-w) were synthesizedaccording to the procedures reported in theliteratures.[1,2]Thionyl chloride (10 mL) was added tosubstituted 2-bromobenzoic acid (5 mol) in a 50 mL round bottom flask, and the reaction mixturewas refluxed for 2 h. The excess amount of thionyl chloride was removed by distillation. Theresulted acid chloride was dissolved in MeOH (20 mL), and then 40% hydrazine hydrate (3 mL)was added. The mixture was refluxed for 2 h and then cooled to room temperature, and the resulting precipitate was collected, washed with distilled water and recrystallized fromethanol.Subsequently,another acylchloride (2 mmol) was added to a solution of substituted 2-bromobenzohydrazide (1 mmol) and pyridine (2 mmol) in NMP (6 mL), the mixture was stirred for12 h, and the resulting solution was poured into ice water. The solid product was filtered andcrystallized from EtOH to get pure 1a-w.
 

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