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[ CAS No. 15121-89-8 ] {[proInfo.proName]}

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Chemical Structure| 15121-89-8
Chemical Structure| 15121-89-8
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Product Details of [ 15121-89-8 ]

CAS No. :15121-89-8 MDL No. :MFCD00011533
Formula : C12H12O3 Boiling Point : -
Linear Structure Formula :- InChI Key :ACXLBHHUHSJENU-CMDGGOBGSA-N
M.W : 204.22 Pubchem ID :5369605
Synonyms :

Safety of [ 15121-89-8 ]

Signal Word:Danger Class:9
Precautionary Statements:P201-P202-P261-P264-P270-P272-P273-P280-P301+P312+P330-P302+P352+P312+P362+P364-P305+P351+P338+P310-P308+P313-P391-P405-P501 UN#:3082
Hazard Statements:H302+H312-H315-H317-H318-H341-H410 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 15121-89-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 15121-89-8 ]

[ 15121-89-8 ] Synthesis Path-Downstream   1~28

  • 4
  • [ 1143-38-0 ]
  • [ 15121-89-8 ]
  • ethyl 2-(1,8-dihydroxy-9-oxo-9,10-dihydroanthracen-10-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • ethyl 2-(1,8-dihydroxy-9-oxo-9,10-dihydroanthracen-10-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at -20℃; for 7h; Title compound not separated from byproducts;
  • 5
  • [ 496-64-0 ]
  • [ 15121-89-8 ]
  • ethyl exo-8-benzoyl-4-hydroxy-3-oxo-2-oxabicyclo[2.2.2]oct-5-ene-7-carboxylate [ No CAS ]
  • ethyl ent-exo-8-benzoyl-4-hydroxy-3-oxo-2-oxabicyclo[2.2.2]oct-5-ene-7-carboxylate [ No CAS ]
  • 7
  • [ 15121-89-8 ]
  • [ 87333-19-5 ]
  • 8
  • [ 15121-89-8 ]
  • [ 82717-96-2 ]
  • 9
  • [ 10009-20-8 ]
  • [ 15121-89-8 ]
  • N2-(1-ethoxycarbonyl-3-phenyl-propyl)-N6-trifluoroacetyl-L-lysine [ No CAS ]
YieldReaction ConditionsOperation in experiment
To 100 ml of ethanol were added 9.69 g of N6-trifluoroacetyl-L-lysine and 8.16 g of trans-ethyl -benzoylacrylate. Thereto was added 40 ml of 1N aqueous solution of lithium hydroxide over about 2 hours with stirring, while maintaining the temperature at about -5C, and the stirring was further continued for 30 minutes. The reaction was terminated by adding 10 ml of concentrated hydrochloric acid thereto. To the reaction mixture were added 130 ml of ethanol and 5 g of 10 % palladium-carbon, and a reduction reaction was carried out at about 40C under ordinary pressure. After the reaction, the catalyst was removed by suction filtration. The obtained ethanol solution was adjusted to about pH 4 with sodium hydroxide, added with water and concentrated under reduced pressure to distil away ethanol so as to replace the solvent with water. The resulting crystals were filtered with suction and dried under vacuum to give 33 g of N2-(1-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysine (1S/1R ratio = 80/20).
  • 10
  • [ 15121-89-8 ]
  • [ 7063-99-2 ]
  • 11
  • [ 28868-76-0 ]
  • [ 15121-89-8 ]
  • C17H19ClO7 [ No CAS ]
  • 12
  • [ 28868-76-0 ]
  • [ 15121-89-8 ]
  • C17H19ClO7 [ No CAS ]
  • C17H19ClO7 [ No CAS ]
  • 13
  • [ 15121-89-8 ]
  • [ 49543-63-7 ]
  • C23H28O3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
With 1,4-diaza-bicyclo[2.2.2]octane In dichloromethane at 20℃; General procedure for preparation of racemates (GP4) General procedure: DABCO (10 mol%) was added to solution of thiol (1.5 equiv) in dichloromethane (2.5 mL) and resulted solution was stirred for 15 minutes at r.t. followed by addition of Michael acceptor (0.3 or 0.5 mmol). After 18-21 h whole reaction mixture was loaded onto a plug of silica gel, as described above (GP1).
  • 14
  • [ 1071-46-1 ]
  • [ 1074-12-0 ]
  • [ 288-36-8 ]
  • [ 15121-89-8 ]
  • ethyl 4-oxo-4-phenyl-3-(2H-1,2,3-triazol-2-yl)butanoate [ No CAS ]
  • 15
  • [ 1071-46-1 ]
  • [ 1074-12-0 ]
  • [ 288-36-8 ]
  • [ 15121-89-8 ]
  • ethyl 4-oxo-4-phenyl-2-(2H-1,2,3-triazol-2-yl)butanoate [ No CAS ]
  • 16
  • [ 1071-46-1 ]
  • [ 1074-12-0 ]
  • [ 288-36-8 ]
  • [ 15121-89-8 ]
  • ethyl 4-oxo-4-phenyl-3-(2H-1,2,3-triazol-2-yl)butanoate [ No CAS ]
  • ethyl 4-oxo-4-phenyl-2-(2H-1,2,3-triazol-2-yl)butanoate [ No CAS ]
  • ethyl 3-hydroxy-4-oxo-4-phenylbutanoate [ No CAS ]
  • 17
  • [ 1520-70-3 ]
  • [ 15121-89-8 ]
  • ethyl (2E)-4-((ethylsulfonyl)imino)-4-phenylbut-2-enoate [ No CAS ]
  • 18
  • [ 15121-89-8 ]
  • [ 42854-62-6 ]
  • [ 87269-98-5 ]
YieldReaction ConditionsOperation in experiment
70.4 g With triethylamine; In ethanol; at 15℃; for 32h; In a four-necked flask, 71.8 g (0.35 mol) of ethyl 3-benzoylacrylate was added. <strong>[42854-62-6]L-alanine benzyl ester p-toluenesulfonate</strong> 123.7 g (0.35 mol), 280 ml of anhydrous ethanol and 41.7 g (0.41 mol) of triethylamine were reacted at 15C for 32 hours. The crystals were crystallized and filtered to obtain 70.4 g of N-[(1S)-1-ethoxycarbonyl-3-phenyl-3-oxopropyl]-L-alanine benzyl ester. The filtered mother liquor is left for use.
  • 19
  • [ 10009-20-8 ]
  • [ 15121-89-8 ]
  • [ 199002-02-3 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; lithium hydroxide; In ethanol; at 15℃; for 0.666667h; When 95% ethanol was added to a 130ml four-necked flask, 11.4 g of 3-benzoyl-acrylate, N6-trifluoroacetyl-lysine -L- 12g, the reaction solution was cooled to 0 deg.] C, was added dropwise to the flask A 1.0 mol/L pre-chilled lithium hydroxide solution (50 ml) was added and stirring was continued for 40 ± 5 minutes. After completion of the reaction, 12 ml of purified hydrochloric acid was added to the reaction mixture, followed by stirring for 20 minutes to obtain a lyo-adduct reaction solution, which was left to stand.
  • 20
  • [ 4214-79-3 ]
  • [ 15121-89-8 ]
  • ethyl (R)-2-(5-chloro-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • ethyl (S)-2-(5-chloro-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • 21
  • [ 4214-79-3 ]
  • [ 15121-89-8 ]
  • ethyl 2-(5-chloro-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • 22
  • [ 15121-89-8 ]
  • [ 51173-05-8 ]
  • ethyl (R)-2-(5-fluoro-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • ethyl (S)-2-(5-fluoro-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • 23
  • [ 15121-89-8 ]
  • [ 51173-05-8 ]
  • ethyl 2-(5-fluoro-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • 24
  • [ 13466-35-8 ]
  • [ 15121-89-8 ]
  • ethyl (R)-2-(3-chloro-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • 25
  • [ 13466-35-8 ]
  • [ 15121-89-8 ]
  • ethyl 2-(3-chloro-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • 26
  • [ 13466-43-8 ]
  • [ 15121-89-8 ]
  • ethyl (R)-2-(3-bromo-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • 27
  • [ 13466-43-8 ]
  • [ 15121-89-8 ]
  • ethyl 2-(3-bromo-2-oxopyridin-1(2H)-yl)-4-oxo-4-phenylbutanoate [ No CAS ]
  • 28
  • [ 15121-89-8 ]
  • [ 29211-44-7 ]
  • ethyl (2E,4E)-4-(3-(2-ethoxy-2-oxoethyl)-5-oxo-1-phenyl-1,5-dihydro-4Hpyrazol-4-ylidene)-4-phenylbut-2-enoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.4 g With pyridine; titanium(IV) isopropylate In tetrahydrofuran at -10 - 30℃; Inert atmosphere;
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Technical Information

• 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Additions of Organometallic Reagents • Acetal Formation • Acid-Catalyzed Equilibration of Alkenes • Acid-Catalyzed Rearrangement of Alkenes • Acid-Catalyzed α -Halogenation of Ketones • Acyl Group Substitution • Add Hydrogen Cyanide to Aldehydes and Ketones to Produce Alcohols • Addition of a Hydrogen Halide to an Internal Alkyne • Addition of Hydrogen Halides Forms Geminal Dihaloalkanes • Addition of Radicals to Alkenes • Alcohol Syntheses from Aldehydes, Ketones and Organometallics • Alcohols Convert Acyl Chlorides into Esters • Alcoholysis of Anhydrides • Aldehydes and Ketones Form Hemiacetals Reversibly • Aldehydes May Made by Terminal Alkynes Though Hydroboration-oxidation • Aldol Addition • Aldol Condensation • Alkene Hydration • Alkenes React with Ozone to Produce Carbonyl Compounds • Alkylation of Aldehydes or Ketones • Alkylation of Enolate Ions • Allylic Deprotonation • Allylic Halides Undergo SN1 Reactions • Allylic Substitution • Amines Convert Esters into Amides • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Base-Catalyzed Hydration of α,β -Unsaturated Aldehydes and Ketones • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Birch Reduction of Benzene • Blanc Chloromethylation • Bouveault-Blanc Reduction • Brown Hydroboration • Bucherer-Bergs Reaction • Carbene Addition to Double Bonds • Catalytic Hydrogenation • Catalytic Hydrogenation of Alkenes • Claisen Condensations Produce β-Dicarbonyl Compounds • Claisen Condensations Produce β-Dicarbonyl Compounds • Clemmensen Reduction • Complete Benzylic Oxidations of Alkyl Chains • Complete Benzylic Oxidations of Alkyl Chains • Complex Metal Hydride Reductions • Conjugated Enone Takes Part in 1,4-Additions • Conversion of Amino with Nitro • Convert Esters into Aldehydes Using a Milder Reducing Agent • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Cyanohydrins can be Convert to Carbonyl Compounds under Basic Conditions • Decarboxylation of 3-Ketoacids Yields Ketones • Decarboxylation of Substituted Propanedioic • Deoxygenation of the Carbonyl Group • Deprotection of Cbz-Amino Acids • Deprotonation of a Carbonyl Compound at the α -Carbon • Deprotonation of Methylbenzene • Dimerization, Oligomerization of Alkenes • Diorganocuprates Convert Acyl Chlorides into Ketones • Directing Electron-Donating Effects of Alkyl • Dissolving-Metal Reduction of an Alkyne • Dithioacetal Formation • Electrocyclic Reactions • Electrophilic Addition of Halogen to Alkynes • Electrophilic Addition of HX to Alkenes • Electrophilic Chloromethylation of Polystyrene • Elimination from Dihaloalkanes to Give Haloalkenes • Enamine Formation • Enamines Can Be Used to Prepare Alkylated Aldehydes • Enol-Keto Equilibration • Enolate Ions Are Protonated to Form ketones • Epoxidation • Epoxidation by Peroxycarboxylic Acids • Ester Cleavage • Ester Hydrolysis • Ether Synthesis by Oxymercuration-Demercuration • Exclusive 1,4-Addition of a Lithium Organocuprate • Fischer Indole Synthesis • Friedel-Crafts Alkylation of Benzene with Acyl Chlorides • Friedel-Crafts Alkylation of Benzene with Carboxylic Anhydrides • Friedel-Crafts Alkylation Using Alkenes • Friedel-Crafts Alkylations of Benzene Using Alkenes • Friedel-Crafts Alkylations Using Alcohols • Friedel-Crafts Reaction • Furan Hydrolyzes to Dicarbonyl Compounds • Geminal Diols and Acetals Can Be Hydrolyzed to Carbonyl Compounds • Grignard Reaction • Grignard Reagents Transform Esters into Alcohols • Groups that Withdraw Electrons Inductively Are Deactivating and Meta Directing • Halogen and Alcohols Add to Alkenes by Electrophilic Attack • Halogen and Alcohols Add to Alkenes by Electrophilic Attack • Halogenation • Halogenation of Alkenes • Halogenation of Benzene • Halogenation-double Dehydrohalogenation • Hantzsch Pyridine Synthesis • Heck Reaction • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • Henry Nitroaldol Reaction • HIO4 Oxidatively Degrades Vicinal Diols to Give Carbonyl Derivatives • Horner-Wadsworth-Emmons Reaction • Hydration of the Carbonyl Group • Hydride Reductions • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydride Reductions of Aldehydes and Ketones to Alcohols • Hydroboration-Oxidation • Hydrogen Bromide Add to Alkenes in Anti-Markovnikov Fashion • Hydrogenation • Hydrogenation by Palladium on Carbon Gives the Saturated Carbonyl Compound • Hydrogenation to Cyclohexane • Hydrogenation with Lindlar Catalyst • Hydrogenation with Lindlar Catalyst • Hydrogenolysis of Benzyl Ether • Hydrolysis of Imines to Aldehydes and Ketones • Hydroxylation • Imine Formation from Amines and Aldehydes or Ketones • Isomerization of β, γ -Unsaturated Carbonyl Compounds • Ketone Synthesis from Nitriles • Ketones Undergo Mixed Claisen Reactions to Form β-Dicarbonyl Compounds • Lawesson's Reagent • Leuckart-Wallach Reaction • Lithium Organocuprate may Add to the α ,β -Unsaturated Carbonyl Function in 1,4-Fashion • Mannich Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Mercury Ions Catalyze Alkynes to Ketones • Michael Addition • Nitration of Benzene • Nucleophilic Aromatic Substitution • Nucleophilic Aromatic Substitution with Amine • Osmium Tetroxide Reacts with Alkenes to Give Vicinal Diols • Oxidation of Alcohols to Carbonyl Compounds • Oxidation of Alkyl-substituted Benzenes Gives Aromatic Ketones • Oxidative Cleavage of Double Bonds • Oxymercuration-Demercuration • Passerini Reaction • Paternò-Büchi Reaction • Pauson-Khand Cyclopentenone Synthesis • Petasis Reaction • Peterson Olefination • Phenylhydrazone and Phenylosazone Formation • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Polymerization of Alkenes • Preparation of Aldehydes and Ketones • Preparation of Alkenes • Preparation of Alkenes by Dehydration of Alcohols • Preparation of Alkenes by Dehydration of Alcohols • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Pyrroles, Furans, and Thiophenes are Prepared from γ-Dicarbonyl Compounds • Radical Addition of a Thiol to an Alkene • Radical Addition of HBr to Terminal Alkynes • Radical Addition of HBr to Terminal Alkynes • Radical Allylic Substitution • Reactions of Aldehydes and Ketones • Reactions of Alkenes • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Reduction of an Ester to an Alcohol • Reduction of an Ester to an Aldehyde • Reductive Amination • Reductive Amination • Reductive Removal of a Diazonium Group • Reformatsky Reaction • Reverse Sulfonation——Hydrolysis • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Sharpless Asymmetric Amino Hydroxylation • Sharpless Asymmetric Dihydroxylation • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Stobbe Condensation • Strecker Synthesis • Sulfonation of Benzene • Tebbe Olefination • The Acylium Ion Attack Benzene to Form Phenyl Ketones • The Claisen Rearrangement • The Cycloaddition of Dienes to Alkenes Gives Cyclohexenes • The Heck Reaction • The Nitro Group Conver to the Amino Function • The Reaction of Alkynyl Anions with Carbonyl Derivatives • The Wittig Reaction • Thiazolium Salt Catalysis in Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Thiazolium Salts Catalyze Aldehyde Coupling • Transesterification • Ugi Reaction • Use 1,3-dithiane to Prepare of α-Hydroxyketones • Vicinal Anti Dihydroxylation of Alkenes • Vilsmeier-Haack Reaction • Wacker Oxidation • Wittig Reaction • Wolff-Kishner Reduction • Woodward Cis-Dihydroxylation
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; ;