Alternatived Products of [ 153005-55-1 ]
Alternatived Products of [ 153005-55-1 ]
Product Details of [ 153005-55-1 ]
CAS No. : | 153005-55-1 |
MDL No. : | MFCD00149980 |
Formula : |
C16H38FNO
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | N/A |
M.W : | 279.48 g/mol |
Pubchem ID : | 16211673 |
Synonyms : |
|
Safety of [ 153005-55-1 ]
Application In Synthesis of [ 153005-55-1 ]
- Downstream synthetic route of [ 153005-55-1 ]
- 1
-
(3R,4R)-4-(Biphenyl-4-ylcarbonyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-benzoylamino]-azepane-1-carboxylic acid tert-butyl ester
[ No CAS ]

-
[ 22206-57-1 ]

-
(3R,4R)-4-(Biphenyl-4-ylcarbonyloxy)-3-(4-hydroxy-benzoylamino)-azepane-1-carboxylic acid tert-butyl ester
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
89% |
With sodium chloride; citric acid; In tetrahydrofuran; |
A. 754 mg of (3R,4R)-4-(Biphenyl-4-ylcarbonyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-benzoylamino]-azepane-1-carboxylic acid tert-butyl ester were dissolved in 10 ml tetrahydrofuran and 147 mg of tetrabutylammoniumfluoride trihydrate were added at 0° C. and the reaction mixture was stirred for two hours at room temperature. 2.5 ml of a saturated solution of sodium chloride and 2.5 ml of an aqueous 1 molar solution of citric acid were added. The organic layer was concentrated under vacuo diluted with ethyl acetate then washed with 5 ml of a saturated solution of sodium chloride dried over magnesium sulfate and evaporated. The crude compound was purified on silica gel (dichloromethane:ethylacetate 1:1) to yield 551 mg (89percent yield) of (3R,4R)-4-(Biphenyl-4-ylcarbonyloxy)-3-(4-hydroxy-benzoylamino)-azepane-1-carboxylic acid tert-butyl ester. MS: 531 (M+H)+; IR: 3352, 2967, 2933, 1713, 1666, 1609, 1540, 1505, 1417 cm-1 |