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[ CAS No. 153005-55-1 ]

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Chemical Structure| 153005-55-1
Chemical Structure| 153005-55-1
Structure of 153005-55-1 * Storage: {[proInfo.prStorage]}

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Product Details of [ 153005-55-1 ]

CAS No. :153005-55-1 MDL No. :MFCD00149980
Formula : C16H38FNO Boiling Point : -
Linear Structure Formula :- InChI Key :N/A
M.W :279.48 g/mol Pubchem ID :16211673
Synonyms :

Safety of [ 153005-55-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 153005-55-1 ]

  • Downstream synthetic route of [ 153005-55-1 ]

[ 153005-55-1 ] Synthesis Path-Downstream   1~1

  • 1
  • (3R,4R)-4-(Biphenyl-4-ylcarbonyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-benzoylamino]-azepane-1-carboxylic acid tert-butyl ester [ No CAS ]
  • [ 22206-57-1 ]
  • (3R,4R)-4-(Biphenyl-4-ylcarbonyloxy)-3-(4-hydroxy-benzoylamino)-azepane-1-carboxylic acid tert-butyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With sodium chloride; citric acid; In tetrahydrofuran; A. 754 mg of (3R,4R)-4-(Biphenyl-4-ylcarbonyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-benzoylamino]-azepane-1-carboxylic acid tert-butyl ester were dissolved in 10 ml tetrahydrofuran and 147 mg of tetrabutylammoniumfluoride trihydrate were added at 0° C. and the reaction mixture was stirred for two hours at room temperature. 2.5 ml of a saturated solution of sodium chloride and 2.5 ml of an aqueous 1 molar solution of citric acid were added. The organic layer was concentrated under vacuo diluted with ethyl acetate then washed with 5 ml of a saturated solution of sodium chloride dried over magnesium sulfate and evaporated. The crude compound was purified on silica gel (dichloromethane:ethylacetate 1:1) to yield 551 mg (89percent yield) of (3R,4R)-4-(Biphenyl-4-ylcarbonyloxy)-3-(4-hydroxy-benzoylamino)-azepane-1-carboxylic acid tert-butyl ester. MS: 531 (M+H)+; IR: 3352, 2967, 2933, 1713, 1666, 1609, 1540, 1505, 1417 cm-1
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