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[ CAS No. 153403-53-3 ]

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Chemical Structure| 153403-53-3
Chemical Structure| 153403-53-3
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Product Details of [ 153403-53-3 ]

CAS No. :153403-53-3 MDL No. :MFCD16250625
Formula : C7H3ClFNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :171.56 g/mol Pubchem ID :14748832
Synonyms :

Safety of [ 153403-53-3 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 153403-53-3 ]

  • Upstream synthesis route of [ 153403-53-3 ]
  • Downstream synthetic route of [ 153403-53-3 ]

[ 153403-53-3 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 145096-57-7 ]
  • [ 153403-53-3 ]
YieldReaction ConditionsOperation in experiment
38% at 80℃; for 6 h; Into a 500-mL round-bottom flask, was placed 6-fluoro-2,3-dihydro-l,3-benzoxazole-2- thione (9.2 g, 54.38 mmol, 1.00 equiv), thionyl chloride (200 mL) and DMF(0.5 mL). The resulting solution was stirred for 6 h at 80°C in an oil bath. After reaction, the excess of SOCh was removed under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (0/100-7/93). The fractions were collected and concentrated under vacuum. This resulted in 3.5 g (38percent) of the title compound as brown oil. LC-MS (ES, m/z) 172 [M+H]+
Reference: [1] Patent: WO2014/164749, 2014, A1, . Location in patent: Page/Page column 257
  • 2
  • [ 145096-57-7 ]
  • [ 153403-53-3 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 1975 - 1980
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 16, p. 4689 - 4693
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049
  • 3
  • [ 53981-24-1 ]
  • [ 153403-53-3 ]
Reference: [1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 16, p. 4689 - 4693
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 1975 - 1980
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 9, p. 3044 - 3049
[4] Patent: WO2014/164749, 2014, A1,
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