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Structure of 153435-79-1

Chemical Structure| 153435-79-1

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Product Details of [ 153435-79-1 ]

CAS No. :153435-79-1
Formula : C7H8BrNO2S
M.W : 250.11
SMILES Code : O=S(C1=CC=CC(Br)=C1)(NC)=O
MDL No. :MFCD07363818
InChI Key :UVSNSICXRVZAJR-UHFFFAOYSA-N
Pubchem ID :7213265

Safety of [ 153435-79-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 153435-79-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 153435-79-1 ]

[ 153435-79-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 22237-13-4 ]
  • [ 153435-79-1 ]
  • 4`-ethoxy-N-methyl-(1,1`-biphenyl)-3-sulfonamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; cesium fluoride; In 1,2-dimethoxyethane; at 80℃; for 22h;Schlenk technique; Inert atmosphere; A 15 mL Schlenk tube was dried under vacuum, filled with nitrogen and charged consecutively with 58.9mg (235 μmol, 1.00 eq) 3-bromo-N-methylbenzenesulfonamide (27c), 39.1 mg (235 μmol, 1.00 eq) 4-ethoxyphenylboronic acid, 9.60 mg (12.0 μmol, 0.05 eq) PdCl2(dppf)*DCM, 111 mg (729 μmol, 3.10 eq)CsF and 2.3 mL anhydrous DME. The suspension was stirred at 80 C for 22 h. TLC analysis and GCMSanalysis indicated full conversion of the starting material. The reaction mixture was hydrolyzed byaddition of 10 mL 5% aqueous HCl solution and diluted with 10 mL EtOAc. The layers were separatedand the organic layer was washed with 8 mL 5% aqueous HCl solution, dried over MgSO4 andconcentrated under reduced pressure. Final purification via column chromatography (CH/EtOAc 3:1,size: 17.5 x 2.0 cm, 14 g silica gel) yielded the pure product as beige solid (57 mg, 86 %).
 

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