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[ CAS No. 1552-42-7 ]

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2D
Chemical Structure| 1552-42-7
Chemical Structure| 1552-42-7
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Product Details of [ 1552-42-7 ]

CAS No. :1552-42-7MDL No. :MFCD00070611
Formula : C26H29N3O2 Boiling Point : 609.4°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :415.53Pubchem ID :73773
Synonyms :

Computed Properties of [ 1552-42-7 ]

TPSA : 36 H-Bond Acceptor Count : 5
XLogP3 : - H-Bond Donor Count : 0
SP3 : 0.27 Rotatable Bond Count : 5

Safety of [ 1552-42-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305 P351 P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1552-42-7 ]

  • Upstream synthesis route of [ 1552-42-7 ]
  • Downstream synthetic route of [ 1552-42-7 ]

[ 1552-42-7 ] Synthesis Path-Upstream   1~8

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YieldReaction ConditionsOperation in experiment
95.4% With hydrogenchloride; sodium hydroxide In water EXAMPLE 1
To a 500 ml reaction vessel, 21.5 g of 2-[4,4'-bis(dimethylamino) benzhydryl]-5-dimethylaminobenzoic acid having a purity of 97.0percent was charged and 250 g of water was added.
To the dispersion thus obtained, 21.5 g of activated carbon; SHIRASAGI-C (manufactured by Takeda Chemical Ind. Co.) and 2.0 g of a 49percent aqueous NaOH solution were added and stirred at 90 to 95° C.
Through the reaction system thus obtained air was blown for 9 hours at a rate of 400 ml/min.
After finishing the reaction, the reaction mass was filtered and the obtained cake was slurried in water, and completely dissolved by adding 19.5 g of a 36percent aqueous HCl solution.
Thereafter, the activated carbon was filtered.
The filtrate was neutralized to pH7.0 with a 49percent aqueous NaOH solution.
The precipitated crystals were filtered, washed and dried to obtain 20.1 g of 3,3-bis(4-dimethylaminophenyl)-6-dimethylaminophthalide.
The yield was 95.4percent.
Formation of by-product in the reaction was 1.5percent.
Selectivity of reaction was 98.4percent.
6.8 g With dihydrogen peroxide In water for 2.00 h; Taking urea 2.4g dissolved in 10 ml water, to which slowly dropping in 3 ml concentrated sulfuric acid, then adding 3.07g p-dimethylaminobenzaldehyde, heating to 50 °C, reaction 2h, after adding 2.5 ml of dimethylaniline, raising the temperature to 80 °C, thermal insulation 2h, adding 3.33g p-dimethylaminobenzoic acid, heating to 90 °C, thermal insulation 2h, add 20 ml water, thermal insulation 8h, natural cooling to room temperature, in the 50 °C, to drop by the 10g potassium hydroxide, 100 ml of water and 6 ml of the ammonia solution in a, adding 0.1g copper sulfate pentahydrate, heating to 70 °C, to wherein the instillment by 12mL 30percent hydrogen peroxide and 24 ml water into solution, dropping 2h, cooling, filtering, drying to obtain the product 6.8 g.
Reference: [1] Patent: US5973168, 1999, A
[2] Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 10, p. 2012 - 2014[3] Zhurnal Organicheskoi Khimii, 1986, vol. 22, # 10, p. 2240 - 2241
[4] Patent: US4595768, 1986, A
[5] Patent: US4271075, 1981, A
[6] Patent: US4271075, 1981, A
[7] Patent: US4271075, 1981, A
[8] Patent: CN106565650, 2017, A. Location in patent: Paragraph 0017; 0018
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Reference: [1] Patent: US4595768, 1986, A
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Reference: [1] Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 10, p. 2012 - 2014[2] Zhurnal Organicheskoi Khimii, 1986, vol. 22, # 10, p. 2240 - 2241
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  • [ 29199-08-4 ]
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Reference: [1] Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 10, p. 2012 - 2014[2] Zhurnal Organicheskoi Khimii, 1986, vol. 22, # 10, p. 2240 - 2241
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Reference: [1] Patent: CN106565650, 2017, A
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Reference: [1] Patent: CN106565650, 2017, A
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  • [ 76339-00-9 ]
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  • [ 76918-85-9 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1980, vol. 28, # 12, p. 3561 - 3569
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  • [ 29199-07-3 ]
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Reference: [1] Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 10, p. 2012 - 2014[2] Zhurnal Organicheskoi Khimii, 1986, vol. 22, # 10, p. 2240 - 2241
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