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Product Details of [ 156-57-0 ]

CAS No. :156-57-0 MDL No. :MFCD00012904
Formula : C2H8ClNS Boiling Point : -
Linear Structure Formula :- InChI Key :OGMADIBCHLQMIP-UHFFFAOYSA-N
M.W : 113.61 Pubchem ID :9082
Synonyms :
2-Aminoethanethiol hydrochloride;2-Mercaptoethylamine hydrochloride;β-Mercaptoethylamine;CI-9148;Cysteamine (hydrochloride);Mercaptamine;Cysteamine HCl
Chemical Name :2-Aminoethanethiol hydrochloride

Calculated chemistry of [ 156-57-0 ]      Expand+

Physicochemical Properties

Num. heavy atoms : 5
Num. arom. heavy atoms : 0
Fraction Csp3 : 1.0
Num. rotatable bonds : 1
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 29.33
TPSA : 64.82 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.72 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : 0.38
Log Po/w (WLOGP) : 0.68
Log Po/w (MLOGP) : 0.29
Log Po/w (SILICOS-IT) : -0.12
Consensus Log Po/w : 0.25

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -0.72
Solubility : 21.8 mg/ml ; 0.192 mol/l
Class : Very soluble
Log S (Ali) : -1.31
Solubility : 5.61 mg/ml ; 0.0493 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.32
Solubility : 55.0 mg/ml ; 0.484 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.12

Safety of [ 156-57-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P501-P261-P272-P270-P271-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313-P301+P312+P330-P304+P340+P312-P403+P233-P405 UN#:N/A
Hazard Statements:H302-H315-H319-H317-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 156-57-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 156-57-0 ]
  • Downstream synthetic route of [ 156-57-0 ]

[ 156-57-0 ] Synthesis Path-Upstream   1~26

  • 1
  • [ 156-57-0 ]
  • [ 67-64-1 ]
  • [ 19351-18-9 ]
YieldReaction ConditionsOperation in experiment
348 kg With sodium hydroxide In ethanol; cyclohexane at 78℃; for 10 h; Large scale A process for the preparation of 2,2-dimethyltetrahydrothiazole comprising the steps of:1) Refining: 450 kg of 95percent cysteamine hydrochloride and 450 kg of ethanol were injected at a 1: 1 ratioInto the reactor, cooling crystallization, rejection filter solid phase for pure cysteamine hydrochloride 405kg, obtainedLiquid phase distillation recovery of ethanol 425kg;2) Neutralization: 1350 kg of cyclohexane, 405 kg of pure cysteamine hydrochloride and 430 kg of acetoneInto the reactor, adding liquid caustic soda 405kg to neutral; which liquid alkali accounted for in water285 kg, NaOH 120 kg;3) azeotropic dehydration: the reactor temperature rose to 78 , reflux azeotropic dehydration, anti-heatShould be 10 hours;4) filtration: the end of the reaction, cooling to 33 , 182kg filter salt;5) Distillation: The filtrate was distilled to recover 1225 kg of cyclohexane and 230 kg of acetone;Acetone solvent distillation are carried out in the reactor; distillation and condensation are water-cooled plus frozen saltWater freezing;6) Rectification: distillation of the remaining crude oil distillation column distillation products 2,2 - dimethyl tetrahydrothiophene348 kg.
Reference: [1] Ukrainskii Khimicheskii Zhurnal (Russian Edition), 1953, vol. 19, p. 523,527[2] Chem.Abstr., 1955, p. 8255
[3] Agricultural and Biological Chemistry, 1989, vol. 53, # 8, p. 2273 - 2274
[4] Journal of the American Chemical Society, 2008, vol. 130, # 2, p. 428 - 429
[5] Patent: CN106146427, 2016, A, . Location in patent: Paragraph 0038; 0039; 0040; 0041; 0042-0046
  • 2
  • [ 156-57-0 ]
  • [ 105-36-2 ]
  • [ 20196-21-8 ]
Reference: [1] Journal of the American Chemical Society, 1994, vol. 116, # 13, p. 5662 - 5666
[2] Patent: US2012/29187, 2012, A1, . Location in patent: Page/Page column 45
  • 3
  • [ 156-57-0 ]
  • [ 96125-49-4 ]
  • [ 20196-21-8 ]
  • [ 130056-74-5 ]
  • [ 130056-73-4 ]
Reference: [1] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 4, p. 1085 - 1089
  • 4
  • [ 1118-61-2 ]
  • [ 156-57-0 ]
  • [ 107-02-8 ]
  • [ 1721-23-9 ]
  • [ 1224866-48-1 ]
Reference: [1] Tetrahedron, 2010, vol. 66, # 15, p. 2815 - 2822
  • 5
  • [ 156-57-0 ]
  • [ 298-12-4 ]
  • [ 16310-13-7 ]
Reference: [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 7, p. 1427 - 1429
[2] Journal of Agricultural and Food Chemistry, 2002, vol. 50, # 19, p. 5394 - 5399
[3] Journal of Medicinal Chemistry, 1978, vol. 21, # 2, p. 165 - 169
[4] Bulletin of the Chemical Society of Japan, 1989, vol. 62, # 10, p. 3247 - 3251
[5] Chemical Communications, 2018, vol. 54, # 12, p. 1501 - 1504
  • 6
  • [ 156-57-0 ]
  • [ 10191-60-3 ]
  • [ 26364-65-8 ]
YieldReaction ConditionsOperation in experiment
93% With sodium carbonate In water at 10 - 20℃; for 2 h; Example 1Into a solution of 26.5 g of sodium carbonate in 150 ml of water are metered, at room temperature, 28.8 g of cysteamine hydrochloride. The reaction mixture is cooled to 100C and 37.1 g of dimethyl N-cyanocarbonimidodithiocarbonate are metered in. After the end of the metered addition, the mixture is stirred at 1O0C for a further 2 hours and then heated to 200C. At 200C, 37 g of 20percent hydrochloric acid are added dropwise. The mixture is then filtered and the solids are washed with 100 ml of water. After drying under reduced pressure, 30.3 g of cyanimino-l,3-thiazolidine are obtained (corresponds to a yield of 94.7percent).Example 2Into a solution of 26.5 g of sodium carbonate in 150 ml of water are metered, at room temperature, 28.8 g of cysteamine hydrochloride. The reaction mixture is cooled to 100C and 37.1 g of dimethyl N-cyanocarbonimidodithiocarbonate are metered in. After the end of the metered addition, the mixture is stirred at 1O0C for a further 2 hours and then heated to 200C. The mixture is subsequently filtered and the solids are washed with 2 x 100 ml of water. After drying under reduced pressure, 29.8 g of cyanimino-l,3-thiazolidine are obtained (corresponds to a yield of 93 percent).
92% With sodium hydrogencarbonate In water at 10 - 20℃; for 3 h; Example 3Into a solution of 23.8 g of sodium hydrogencarbonate in 200 ml of water are metered, at room temperature, 28.8 g of cysteamine hydrochloride. The reaction mixture is cooled to 100C and 37.1 g of dimethyl N-cyanocarbonimidodithiocarbonate are metered in. After the end of the metered addition, the mixture is stirred at 100C for a further 3 hours and then heated to 200C. The mixture is then filtered and the solids are washed with 100 ml of water. After drying under reduced pressure, 29.4 g of cyanimino-l,3-thiazolidine are obtained (corresponds to a yield of 92percent).
87.5% With sodium hydroxide In water at 0 - 10℃; for 0.666667 h; Add 300 ml of water to the three-necked bottle, then add 16.4 g of sodium hydroxide, stir and dissolve,Cool down to below 10 °C,Rapid addition of cysteamine hydrochloride 56g (0.50 mol),After stirring and dissolving,The temperature was lowered to 0 to 5 ° C, and then a compound HRB-1365-0 (cyanimide dimethyl ester molecular formula: C4H6N2S2) 61 g (0.41 mol) was added, and after stirring for 40 minutes, the reaction was completed and filtered.The filter cake was washed with 200 ml of water, the filter cake was white solid, and the wet product was 57 g.Drying under reduced pressure at 60-65 ° C gave a white crystalline solid 46 g.That is, the compound HRB-1365-2 (2-cyanoimido-1,3-thiazolidine molecular formula: C4H5N3S),The yield was 87.5percent, and the HPLC (High Performance Liquid Chromatograph) content was ≥99percent.
85.8%
Stage #1: With sodium methylate In methanolInert atmosphere
Stage #2: at 0 - 5℃; Inert atmosphere
Stage #3: With hydrogenchloride In methanol; water at 20 - 40℃; Inert atmosphere
EXAMPLE 3; A 1 litre four-necked flask provided with a thermometer and stirrer is charged with 9Og of methanol (2.815 moles) and 36g of sodium methoxide (0.667 moles, 1.3 mole equivalent based upon 1.1 mole equivalent of 2-aminoethane thiol hydrochloride) under nitrogen. The mixture is cooled and stirred to dissolve in <n="16"/>methanol, then 63.5g of 2-aminoethane thiol hydrochloride (0.564 moles) is added thereto and dissolved therein. The reaction mixture is cooled to 0° C and 75g of dimethyl N-cyanoiminodithiocarbonate (0.514 moles) is added keeping the inside temperature at 5° C or less. After the end of addition, the mixture is allowed to react at 0 to 5° C for 2 hours under nitrogen. Thereafter, the reaction mixture is heated to 20° C and pH is adjusted to 4 with aqueous hydrochloric acid solution (36percent w/w), then further heated to 40° C and stirred for 2 hours. After stirring, the reaction mixture is cooled to 0° C and the crystals are suction filtered and the slurry thus obtained is washed with 225ml of chilled water to obtain 66g of 2-cyanoimino-l, 3-thiazolidine. The wet crystals are dried in vacuo at 80° C under reduced pressure for 5 hours to obtain 58g of 2-cyanoimino-l, 3-thiazolidine (yield 85.8percent) with 99.9percent HPLC purity.
81.6%
Stage #1: With sodium hydroxide In water
Stage #2: for 2 h;
Stage #3: With hydrogenchloride In water at 20 - 40℃; for 2 h;
Example 1
A 300 ml four-necked flask provided with a thermometer and an agitator was charged with 150 g of water (8.3 moles), then 11.2 g of 99percent by weight sodium hydroxide (0.28 mole, 1.12 moles based upon 1 mole of 2-aminoethane thiol hydrochloride) was added while cooling and agitating to be dissolved in the water, then 28.8 g of 99.5percent by weight 2-aminoethane thiol hydrochloride (0.25 mole) was added thereto and dissolved therein, then the reaction mixture was cooled to 0°C.
To this reaction mixture, 36.9 g of 99.5percent by weight dimethyl N-cyanoiminodithiocarbonate ester (0.25 mole) was added so that the temperature inside the system became 5°C or less..
After the end of addition, the mixture was allowed to react at 0 to 5°C for 2 hours.
Thereafter, the reaction mixture was heated to 20°C, adjusted in PH to 4.0 with 36percent by weight aqueous hydrochloric acid solution, then further heated to 40°C and allowed to age for 2 hours.
After aging, the reaction mixture was cooled to 20°C, then the crystals were suction filtered and washed with 100 g of water (5.6 moles) to obtain 36.6 g of 2-cyanoimino-1,3-thiazolidine.
The wet crystals were dried in vacuo at 84°C under 6.7 x 10-4 MPa for 5 hours to obtain 28.6 g of 99.7percent purity 2-cyanoimino-1,3-thiazolidine (yield 89.8percent = value converted to purity, based on the charged dimethyl N-cyanoiminodithiocarbonate ester). Note that the purity was analyzed by means of high pressure liquid chromatography (HPLC). Example 2; A 300 ml four-necked flask provided with a thermometer and an agitator was charged with 150 g of water (8.3 moles), then 12.3 g of 99percent by weight sodium hydroxide (0.31 mole, 1.24 moles based upon 1 mole of 2-aminoethane thiol hydrochloride) was added, while cooling and agitating to be dissolved in the water, then 28.8 g of 99.5percent by weight 2-aminoethane thiol hydrochloride (0.25 mole) was added thereto and dissolved therein. Thereafter, the reaction mixture was cooled to 0°C., then 36.9 g of 99.5percent by weight dimethyl N-cyanoiminodithiocarbonate ester (0.25 mole) was gradually added so that the temperature inside the system became 5°C or less. After the end of addition, the mixture was allowed to react for further 2 hours. Next, the reaction mixture was heated to 20°C, adjusted in pH to 3.9 with 4.56 g (0.045 mole) of 36percent by weight aqueous hydrochloric acid solution, then further heated to 40°C and allowed to age for 2 hours. After aging, the reaction mixture was cooled to 20°C, then suction filtered and washed with 200 g of water (11.1 moles) to obtain 34.7 g of wet crystals of 2-cyanoimino-1,3-thiazolidine. The wet crystals obtained above, were dried in vacuo at 80°C under 6.7 x 10-4 MPa for 5 hours to obtain 27.9 g of 100percent purity 2-cyanoimino-1,3-thiazolidine (yield 87.9percent = value converted to purity, based on charged dimethyl N-cyanoiminodithiocarbonate ester). Further, the total weight of the filtrate combined with the washings was 371.5 g. The filtrate included 0.98percent of 2-cyanoiminothiazolidine (value converted to yield: 11.5percent). Example 3; A 300 ml four-necked flask provided with a thermometer and an agitator was charged with 150 g of water (8.3 moles), then 10.6 g of 99percent by weight sodium hydroxide (0.26 mole, 1.04 moles based upon 1 mole of 2-aminoethane thiol hydrochloride) was added, while cooling and agitating to be dissolved in the water, then 28.8 g of 99.5percent by weight 2-aminoethane thiol hydrochloride (0.25 mole) was added thereto and dissolved therein. Thereafter, the reaction mixture was cooled to 0°C, then 36.9 g of 99.5percent by weight dimethyl N-cyanoiminodithiocarbonate ester (0.25 mole) was gradually added so that the temperature inside the system became 5°C or less, then was allowed to react for 2 hours. Next, the reaction mixture was heated to 20°C, adjusted in pH to 9.2 with 0.25 g of 36percent by weight aqueous hydrochloric acid solution (0.0025 mole), then further heated to 40°C and allowed to age for 2 hours. After aging, the reaction mixture was cooled to 20°C, then suction filtered and washed with 200 g of water (11.1 moles) to obtain 36.33 g of wet crystals of 2-cyanoimino-1,3-thiazolidine. The wet crystals were dried in vacuo at 80°C under 6.7 x 10-4 MPa for 5 hours to obtain 27.2 g of 95.2percent purity 2-cyanoimino-1,3-thiazolidine (yield 81.6percent = value converted to purity, based on the charged dimethyl N-cyanoiminodithiocarbonate ester). Further, the total weight of the filtrate combined with the washings was 361.5 g. The filtrate included 0.95percent of 2-cyanoiminothiazolidine (value converted to yield: 10.8percent).
59.4%
Stage #1: With sodium hydroxide In water
Stage #2: for 2 h;
Stage #3: With hydrogenchloride In water
Comparative Example 2
A 300 ml four-necked flask provided with a thermometer and an agitator was charged with 114 g of water (6.3 moles), then 20.9 g of 99percent by weight sodium hydroxide (0.50 mole) was added, while cooling and agitating, to be dissolved therein, then 28.8 g of 99.5percent by weight 2-aminoethane thiol hydrochloride (0.25 mole) was added thereto and dissolved therein..
Then, the reaction mixture was cooled to 0°C, then 36.9 g of 99.5percent by weight dimethyl N-cyanoiminodithiocarbonate ester (0.25 mole) was gradually added, while holding the temperature to 5°C or less, then the mixture was allowed to react for 2 hours.
Next, 30.9 g of 36percent by weight aqueous hydrochloric acid solution (0.29 mole) was added to try to adjust the PH, but the mixture violently started bubbling at around PH 9.0 and finally the PH became 9.5..
Next, the reaction mixture was suction filtered and washed with 200 g of water (11.1 moles) to obtain 28.6 g of wet crystals of 2-cyanoimino-1,3-thiazolidine.
The wet crystals were dried in vacuo at 80°C under 6.7 x 10-4 MPa for 5 hours to obtain 18.9 g of 100percent purity 2-cyanoimino-1,3-thiazolidine (yield 59.4percent = value converted to purity, based on the charged dimethyl N-cyanoiminodithiocarbonate ester). Comparative Example 3; A 300 ml four-necked flask provided with a thermometer and an agitator was charged with 150 g of water (8.3 moles), then 20.9 g of 99percent by weight sodium hydroxide (0.50 mole) was added, while cooling and agitating, to be dissolved, then 28.8 g of 99.5percent by weight 2-aminoethane thiol hydrochloride (0.25 mole) was added thereto and dissolved therein. Thereafter, the reaction mixture was cooled to 0°C, then 36.9 g of 99.5percent by weight dimethyl N-cyanoiminodithiocarbonate ester (0.25 mole) was gradually added, while holding the temperature to 5°C or less, the mixture was then allowed to react for 2 hours. Next, 31.7 g of 36percent by weight aqueous hydrochloric acid solution (0.31 mole) was added to try to adjust the pH, but the mixture violently started bubbling at around pH 9.0 and finally the pH became 1.7. Next, the reaction mixture was suction filtered and washed with 200 g of water (11.1 moles) to obtain 34.8 g of wet crystals of 2-cyanoimino-1,3-thiazolidine. The wet crystals were dried in vacuo at 80°C under 6.7 x 10-4 MPa for 5 hours to obtain 20.7 g of 100percent purity 2-cyanoimino-1,3-thiazolidine (yield 65.2percent = value converted to purity, based on the charged dimethyl N-cyanoiminodithiocarbonate ester).
47.7%
Stage #1: With sodium hydroxide In water
Stage #2: for 3 h; Heating / reflux
Comparative Example 1
A 300 ml four-necked flask provided with a thermometer and an agitator was charged with 100 g of water (5.6 moles), then 10.1 g of 99percent by weight sodium hydroxide (0.25 mole) was added, while cooling and agitating to dissolve it..
Next, 28.8 g of 99.5percent by weight 2-aminoethane thiol hydrochloride (0.25 mole) was added thereto and dissolved therein, then 36.9 g of dimethyl N-cyanoiminodithiocarbonate ester (0.25 mole) was added and the mixture was heated and refluxed under agitation for 3 hours..
After the end of the reaction, the reaction mixture was cooled to room temperature, then the crystals were suction filtered and washed with methanol and dried in vacuo at 80°C under 6.7 x 10-4MPa for 5 hours to obtain 15.2 g of 99.7percent purity 2-cyanoimino-1,3-thiazolidine (yield 47.7percent = value converted to purity, based on the charged dimethyl N-cyanoiminodithiocarbonate ester).

Reference: [1] Gazzetta Chimica Italiana, 1980, vol. 110, # 5/6, p. 345 - 350
[2] Patent: WO2009/33583, 2009, A1, . Location in patent: Page/Page column 5
[3] Patent: WO2009/33583, 2009, A1, . Location in patent: Page/Page column 5
[4] Patent: CN103387550, 2016, B, . Location in patent: Paragraph 0051; 0052; 0061
[5] Patent: WO2009/113098, 2009, A2, . Location in patent: Page/Page column 14-15
[6] Patent: EP1460068, 2004, A1, . Location in patent: Page 4
[7] Patent: EP1460068, 2004, A1, . Location in patent: Page 5
[8] Patent: EP1460068, 2004, A1, . Location in patent: Page 4; 5
  • 7
  • [ 156-57-0 ]
  • [ 79463-77-7 ]
  • [ 26364-65-8 ]
Reference: [1] Journal of Heterocyclic Chemistry, 1987, vol. 24, # 1, p. 275 - 278
  • 8
  • [ 114326-10-2 ]
  • [ 156-57-0 ]
YieldReaction ConditionsOperation in experiment
17.8 g With hydrogenchloride In water; butan-1-ol at 75℃; for 6 h; In a reaction flask, S-2-(tert-butoxycarbonyl amino)ethyl-ethantionate (45.5 g, 0.17 mol), n-butanol (315.00 ml) and an aqueous solution of 37percent hydrochloric acid (34.29 g, 0.35 mol) were loaded, the temperature was raised to 75° C. and the reaction mixture was maintained under these conditions for about six hours.
Once the reaction is finished, the solvent and the residual water are removed through vacuum distillation, the temperature was cooled to 10° C. and n-butanol was added (40.00 ml); the resulting solid was filtered, washed with n-butanol (2*10.00 ml) and dried in oven under vacuum at about 40° C. to give 17.80 g of cysteamine hydrochloride.
Reference: [1] Patent: US2018/111897, 2018, A1, . Location in patent: Paragraph 0040; 0041
  • 9
  • [ 870-24-6 ]
  • [ 156-57-0 ]
Reference: [1] Patent: US4507500, 1985, A,
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  • [ 96-53-7 ]
  • [ 156-57-0 ]
Reference: [1] Asian Journal of Chemistry, 2010, vol. 22, # 4, p. 3221 - 3227
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  • [ 151-56-4 ]
  • [ 7727-37-9 ]
  • [ 156-57-0 ]
Reference: [1] Patent: US5017725, 1991, A,
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  • [ 78-93-3 ]
  • [ 156-57-0 ]
Reference: [1] Patent: US5017725, 1991, A,
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  • [ 156-57-0 ]
Reference: [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987, p. 111 - 120
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Reference: [1] Patent: US4507500, 1985, A,
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  • [ 156-57-0 ]
Reference: [1] Asian Journal of Chemistry, 2012, vol. 24, # 7, p. 3247 - 3248
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Reference: [1] Chemische Berichte, 1889, vol. 22, p. 1138[2] Chemische Berichte, 1891, vol. 24, p. 1110
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  • [ 134469-06-0 ]
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Reference: [1] Agricultural and Biological Chemistry, 1988, vol. 52, # 11, p. 2911 - 2918
  • 18
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Reference: [1] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986, vol. 22, # 2, p. 161 - 166[2] Khimiya Geterotsiklicheskikh Soedinenii, 1986, vol. 22, # 2, p. 206 - 211
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Reference: [1] Journal of applied toxicology : JAT, 2000, vol. 20 Suppl 1, p. S31-34
[2] Journal of Organic Chemistry, 1994, vol. 59, # 26, p. 8239 - 8244
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, # 4, p. 653 - 658[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 4, p. 749 - 755
[5] Tetrahedron Letters, 2004, vol. 45, # 36, p. 6795 - 6798
[6] Journal of Materials Chemistry B, 2013, vol. 1, # 46, p. 6365 - 6372
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  • [ 120-78-5 ]
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  • [ 56-17-7 ]
Reference: [1] Journal of Organic Chemistry, 1994, vol. 59, # 26, p. 8239 - 8244
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  • [ 156-57-0 ]
  • [ 14446-47-0 ]
Reference: [1] Biochemical and Biophysical Research Communications, 2010, vol. 403, # 3-4, p. 442 - 446
[2] Journal of the American Chemical Society, 1937, vol. 59, p. 200,201, 205
[3] Tetrahedron, 2008, vol. 64, # 17, p. 3691 - 3700
[4] Patent: WO2015/173779, 2015, A1, . Location in patent: Page/Page column 26
  • 22
  • [ 156-57-0 ]
  • [ 70-11-1 ]
  • [ 141849-62-9 ]
Reference: [1] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 16, p. 5616 - 5624
  • 23
  • [ 156-57-0 ]
  • [ 140176-73-4 ]
  • [ 78441-62-0 ]
YieldReaction ConditionsOperation in experiment
88%
Stage #1: With sodium hydroxide; hydroxyammonium sulfate In water at 5 - 10℃; for 1 h;
Stage #2: at 10℃; for 1 h;
2-AMINOETHANETHIOL hydrochloride (cysteamine hydrochloride, 520 G, 4.5 mol) is suspended in water (500 ml). This suspension is cooled to 5 C and sodium hydroxide solution (45 percent w/w, 870 ml; 14.7 mol) is added into it at 5-10 C. Into this suspension, hydroxylamine sulphate (100 g; 0.6 mol) is added and stirred. A solution OF 4-CHLOROMETHYL-2- DIMETHYLAMINOMETHYLTHIAZOLE hydrochloride (1000 G ; 4.43 mol) dissolved in water (1250 ml) is prepared separately. This solution is added into the said suspension below 10 C and the reaction continued at 10 C for another 1 h. The completion of the reaction is determined by qualitative HPLC. The reaction mixture is then diluted with water (2000 ml), heated to 40-45o C and extracted with toluene (2 x 2000 ml). The toluene extract is treated with activated carbon at 40-45o C for 30 min. Activated carbon is removed by filtration through HYFLO bed and evaporated toluene from the filtrate under reduced pressure at 60 C to obtain 910 g of the product. Yield = 88 percent.
Reference: [1] Patent: WO2004/69817, 2004, A1, . Location in patent: Page 8
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  • [ 78441-69-7 ]
  • [ 78441-62-0 ]
YieldReaction ConditionsOperation in experiment
94.6% Reflux Separately, 105 g of 2- (N, N-dimethylamino) -4-thiazolemethanol and 71.5 g of cysteamine hydrochloride were weighed,mixing,Then dissolved in 210 mL of 48percent hydrobromic acid solution,Warmed to reflux temperature,After the reaction of the raw material is completed, a potassium hydroxide solution with a concentration of 50percent is added to the reaction system to adjust the pH of the system to 12,Then extracted six times with toluene,Each 250mL,The combined organic phase,Off to prepare the formula V;The yield of this process was 94.6percentPurity 99.5percent;
Reference: [1] Patent: CN106279060, 2017, A, . Location in patent: Paragraph 0039; 0049; 0058; 0059
[2] Arzneimittel-Forschung/Drug Research, 1985, vol. 35, # 3, p. 573 - 577
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  • [ 82586-71-8 ]
  • [ 78441-62-0 ]
Reference: [1] Patent: US4468517, 1984, A,
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  • [ 50-00-0 ]
  • [ 156-57-0 ]
  • [ 84348-37-8 ]
  • [ 401564-36-1 ]
YieldReaction ConditionsOperation in experiment
89%
Stage #1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 2 h; Inert atmosphere
Stage #2: at 10 - 20℃; for 10 h;
In a dry and clean 1L four-port bottle, add 500ml of dichloromethane and stir.Further 50.0 g (218 mmol) of compound IV and 27.3 g (240 mmol) of compound III are added,Cool the system to 10-20 °C and add 32.4 g (240 mmol)1-Hydroxybenzotriazole, 46.0 g 240 mmol1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, under N2 protection,Temperature control 10 ~ 20 ° C, 59.2g (458mmol) N, N diisopropylethylamine was added dropwise, control 0.5-1h finished. After the completion of the dropwise addition, the temperature was maintained at 0 to 10°C for 2 hours, and the HPLC was followed until the compound IV was ≤ 1percent.The reaction solution was concentrated to 80-120 ml remaining, and 19.6 g (262 mmol) of compound II (40percent formaldehyde aqueous solution) was added dropwise to the system.After 10 hours of incubation at 10 to 20°C, the treatment was started, 250 ml of tap water was added, and the mixture was extracted with ethyl acetate (300 ml each time, extracted twice),,The organic phases were combined and washed once with 150 ml of 1 mol/L hydrochloric acid.Then wash it once with 100ml 20percent aqueous sodium chloride,The organic phase is concentrated to 60-100 ml and 250 ml of n-heptane are added dropwiseCrystallization, precipitation of white solids, cooling to 0-5 °C between 1h, filtration,The compound (S)-tert-butyl 4-oxo-2-(thiazolidine-3-carbonyl)pyrrolidine-1-carboxylate (I) was obtained in a yield of 89.0percent. The HPLC purity was 99.2percent.
Reference: [1] Patent: CN105085510, 2018, B, . Location in patent: Paragraph 0033; 0035; 0036; 0037; 0039; 0041
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