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CAS No. :	156897-06-2
Formula :	C₂₃H₂₂ClNO₂
M.W :	379.88
SMILES Code :	O=C(O)CC1=C(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)=C4N1CC(C)(C)C4
Synonyms :	ML-3000
MDL No. :	MFCD00929900
InChI Key :	UAWXGRJVZSAUSZ-UHFFFAOYSA-N
Pubchem ID :	133021

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H319
Precautionary Statements:	P305+P351+P338

OVCAR8	20 µM	72 hours	To evaluate the effect of Licofelone on reversing stem-like properties in ovarian cancer MCTS. Results showed Licofelone significantly reduced the expression of CD133, ALDH1A, KLF4, NANOG, and SOX2.	Cancer Res. 2018 Aug 1;78(15):4370-4385
Bone marrow cells (IMCs)	2.5, 5, 10 μM	5 days	To investigate the effect of Licofelone on the generation of IMCs. Results showed that Licofelone significantly suppressed the generation of Gr-1+ CD11b+ IMCs and Gr-1− F4/80+ macrophages.	Front Immunol. 2016 Dec 5;7:537
B16F10luc2 melanoma cells	1, 5, 10, 20 μM	48 hours	To evaluate the direct effect of Licofelone on melanoma cell growth and ROS production. Results showed that Licofelone had no significant effect on the viability and ROS production of B16F10luc2 melanoma cells.	Front Immunol. 2016 Dec 5;7:537
Colon tumor spheroids	25 µM	14 days	Evaluate the inhibitory effects of LFA-9 and licofelone on colon tumor spheroid formation. LFA-9 significantly inhibited colon tumor spheroid formation by 60.2%, while licofelone inhibited by 22.3%.	J Inflamm Res. 2020 Dec 31;13:1261-1278
Mouse peritoneal macrophages	0.1–100 µM	24 hours	Evaluate the inhibitory effects of LFA-9 and licofelone on PGE2 and LTB4 production in LPS-stimulated macrophages. LFA-9 inhibited PGE2 and LTB4 production, while licofelone inhibited PGE2, LTB4, and PGI2 production.	J Inflamm Res. 2020 Dec 31;13:1261-1278
Rat peritoneal macrophages	0.1–100 µM	24 hours	Evaluate the inhibitory effects of LFA-9 and licofelone on PGE2 and LTB4 production in LPS-stimulated macrophages. LFA-9 inhibited PGE2 and LTB4 production, while licofelone inhibited PGE2, LTB4, and PGI2 production.	J Inflamm Res. 2020 Dec 31;13:1261-1278
THP1-human monocytes	0.1–100 µM	24 hours	Evaluate the inhibitory effects of LFA-9 and licofelone on PGE2 and LTB4 production in LPS-stimulated macrophages. LFA-9 inhibited PGE2 and LTB4 production, while licofelone inhibited PGE2, LTB4, and PGI2 production.	J Inflamm Res. 2020 Dec 31;13:1261-1278
Candida albicans (CA16)	16 mg/mL	24 hours	Evaluate the synergistic antifungal effect of Licofelone combined with fluconazole against resistant C. albicans, showing a significant reduction in the MIC80 of fluconazole.	Front Microbiol. 2017 Nov 7;8:2101
Candida albicans (CA10)	16 mg/mL	24 hours	Evaluate the synergistic antifungal effect of Licofelone combined with fluconazole against resistant C. albicans, showing a significant reduction in the MIC80 of fluconazole.	Front Microbiol. 2017 Nov 7;8:2101
RAW 264.7 cells	2.7 μM	24 hours	To evaluate the effect of LCF-CSBN on M1 macrophage polarization, results showed that LCF-CSBN significantly reduced the expression of M1 marker iNOS and increased the expression of M2 marker CD206.	Adv Sci (Weinh). 2025 Mar;12(9):e2411911
A1847	10 µM	72 hours	To evaluate the anti-proliferative/cell killing activity of Licofelone in ovarian cancer multicellular tumor spheroids (MCTS). Results showed Licofelone exhibited higher activity in MCTS compared to 2D cultured cells.	Cancer Res. 2018 Aug 1;78(15):4370-4385

Sprague Dawley rats	MIA-induced OA model and ACLT + pMMx-induced OA model	Intra-articular injection	40 μg	Every 4 weeks for 8 weeks	To evaluate the therapeutic effect of LCF-CSBN in vivo, results showed that LCF-CSBN significantly attenuated joint inflammation, oxidative stress, and cartilage degeneration.	Adv Sci (Weinh). 2025 Mar;12(9):e2411911
NOD scid gamma (NSG) mice	Ovarian cancer patient-derived xenograft (PDX) model	Intraperitoneal injection	50 mg/kg		To evaluate the effect of Licofelone in combination with paclitaxel on the survival of ovarian cancer PDX model mice. Results showed the median survival of the combination group (>141 days) was significantly longer than paclitaxel alone (115 days), licofelone alone (37 days), or vehicle (30 days).	Cancer Res. 2018 Aug 1;78(15):4370-4385
C57BL/6 mice	B16F10luc2 melanoma model	Intravenous and subcutaneous injection	5 mg/kg	Once every second day for 14 days	To evaluate the effect of Licofelone combined with a vaccine on the survival rate and immune-suppressive cell populations in melanoma-bearing mice. Results showed that Licofelone combined with the vaccine significantly prolonged the survival time of mice and reduced the number of Gr-1+ CD11b+ IMCs and Gr-1? F4/80+ macrophages in the bone marrow and spleen.	Front Immunol. 2016 Dec 5;7:537
Fischer (F344) rats	Carrageenan-induced rat paw edema model	Oral	400 ppm	Single dose, measurements taken at 1-, 2-, 3-, 4-, 5- and 6-hours after carrageenan injection	Evaluate the anti-inflammatory effects of LFA-9 and licofelone on carrageenan-induced rat paw edema. LFA-9 showed 70.4% edema inhibition at 3 hours post-injection, while licofelone showed 61.7%.	J Inflamm Res. 2020 Dec 31;13:1261-1278
Galleria mellonella	Larvae model infected with resistant C. albicans	Injection	80 mg/mL	Single dose, observed for 4 days	Evaluate the in vivo antifungal activity of Licofelone combined with fluconazole, showing a significant increase in larval survival rate.	Front Microbiol. 2017 Nov 7;8:2101
Male Sprague Dawley rats	Paclitaxel-induced mechanical allodynia model	Oral gavage	50 mg/kg	Acute treatment, administered on day 7 or 9 after the first dose of paclitaxel	Licofelone inhibits COX and LOX and/or directly interacts with CB receptors to produce antiallodynic effects in a rat model of PINP.	Biomedicines. 2024 Jul 11;12(7):1545
Bovine	Early osteoarthritis model	In vitro culture	1 mg mL−1	24 hours	Evaluate the uptake and retention time of Licofelone-PBAE conjugates in cartilage, showing an 18-fold increase in uptake and 37-fold prolongation in retention time.	RSC Adv. 2024 Jan 2;14(1):15-28
A/J mice	NNK-induced lung tumor model	Dietary administration	200 or 400 ppm	Continued for 17 or 34 weeks	To evaluate the preventive effects of licofelone alone or in combination with DFMO on NNK-induced lung tumors. Results showed that licofelone significantly inhibited lung tumor formation, and the effect was more pronounced when combined with DFMO.	Am J Cancer Res. 2016 May 1;6(5):894-909
Swiss H mice	Mainstream cigarette smoke (MCS) exposure model	Dietary administration	960 mg/kg diet	6 weeks starting after weaning	To evaluate the early modulation by licofelone of pulmonary DNA and RNA alterations in smoke-free or MCS-exposed H mice after 10 weeks of exposure. Results showed that licofelone significantly attenuated MCS-induced DNA damage and oxidative DNA damage, and modulated the expression of various pulmonary microRNAs.	Carcinogenesis. 2020 Mar 13;41(1):91-99

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CAS No.: 156897-06-2

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CAS No.: 156897-06-2

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Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed