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Chemical Structure| 1591827-97-2 Chemical Structure| 1591827-97-2

Structure of 1591827-97-2

Chemical Structure| 1591827-97-2

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Product Details of [ 1591827-97-2 ]

CAS No. :1591827-97-2
Formula : C8H10F2N2O2
M.W : 204.17
SMILES Code : OCC1=CC(C(F)(F)C)=NN=C1OC

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Application In Synthesis of [ 1591827-97-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1591827-97-2 ]

[ 1591827-97-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13211-32-0 ]
  • [ 1591827-95-0 ]
  • [ 1591829-38-7 ]
  • [ 1591827-97-2 ]
YieldReaction ConditionsOperation in experiment
With silver nitrate; In water; ethyl acetate; trifluoroacetic acid; Step 4: (6-(1,1-difluoroethyl)-3-methoxypyridazin-4-yl)methanol To a mixture of tert-butoxy-acetic acid (4.23 g, 32.04 mmol) in TFA/water (20 mol percent, 30 mL) were added 3-(1,1-difluoroethyl)-6-methoxypyridazine (3.1 g, 17.8 mmol) and AgNO3 (303 mg, 1.78 mmol). The mixture was flushed with nitrogen with stirring at room temperature, then the mixture was heated to 70° C., and (NH4)2S2O8 (8.12 g, 35.6 mmol) in water (40 mL) was added dropwise. After addition the mixture was stirred at 75° C. for 40 min. After cooling to room temperature, the mixture was extracted with ethyl acetate (20 mL*3), the combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated under reduced pressure to afford crude product (4.63 g, crude). A solution of 4-(tert-butoxymethyl)-6-(1,1-difluoroethyl)-3-methoxypyridazine (4.63 g, crude) in TFA/DCE (10 mL/40 mL) was stirred at 60° C. for 1 hr. After cooling to r.t., the mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (20 mL), washed with aqueous potassium carbonate, brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate (8:1 to 5:1) as eluent) to afford (6-(1,1-difluoroethyl)-3-methoxy pyridazin-4-yl)methanol (2.1 g). MS (ESI) m/z 205 (M+H)+
 

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