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Chemical Structure| 1608148-61-3 Chemical Structure| 1608148-61-3

Structure of 1608148-61-3

Chemical Structure| 1608148-61-3

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Product Details of [ 1608148-61-3 ]

CAS No. :1608148-61-3
Formula : C8H6INO
M.W : 259.04
SMILES Code : N#CC1=CC(C)=C(O)C(I)=C1

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Application In Synthesis of [ 1608148-61-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1608148-61-3 ]

[ 1608148-61-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 15777-70-5 ]
  • [ 1608148-61-3 ]
YieldReaction ConditionsOperation in experiment
66% With ammonium hydroxide; iodine; potassium iodide; In water; To a stirred solution of above product (850 mg, 6.4 mmol) in ammonium hydroxide solution (30 mL) was added a solution of iodine (1 .62 gm, 6.4 mmol) and Kl (3.2 gm, 19.2 mmol) in water (5 mL) and the mixture was stirred for overnight. The solvent was distilled and the crude was taken in 1 M HCI (5 mL) and extracted with ethyl acetate (50 mL). The organic layer was separated and dried over magnesium sulphate and the solvent was distilled to gave the product (1 .1 gm, 66%) as pale paste which was dissolved in dry DMF (8 imL), potassium carbonate (700 mg, 5 mmol) was added follwed by the addition of 2 bromo propane (1 .5 ml_, excess) and the mixture was stirred at reflux for 3 hrs. Thew contenet was diluted with water (30 ml.) and extracted with ethyl acetate (50 ml. x 2). The organic layer was washed with water and dried over magnesium sulphate. The solvent was distilled to gave the product (990 mg, 78%) as pale oil. 1 H-NMR (CDCI3) 7.9 (d, 1 H, J = 1 .95 Hz), 7.42 (d, 1 H, J = 1 .29 Hz), 4.62 - 4.53 (m, 1 H), 2.3 (s, 3H), 1 .34(d, 6H, J = 6.15 Hz
 

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