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Chemical Structure| 161263-35-0 Chemical Structure| 161263-35-0

Structure of 161263-35-0

Chemical Structure| 161263-35-0

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Product Details of [ 161263-35-0 ]

CAS No. :161263-35-0
Formula : C14H12N4
M.W : 236.27
SMILES Code : CC1=CN(C2=CC=CC(C3=NC=CC=C3)=N2)N=C1

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Application In Synthesis of [ 161263-35-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 161263-35-0 ]

[ 161263-35-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 7554-65-6 ]
  • [ 13040-77-2 ]
  • [ 161263-35-0 ]
YieldReaction ConditionsOperation in experiment
91% The reaction was performed under argon. Substituted azole (excess) and potassium tert-butoxide were dissolved at RT in dry and degassed DMSO. An exothermic reaction occurred. The mixture was stirred for 10 min to allow the reaction to finish and cool. Then, a substituted halopyridine was added. The reaction mixture was stirred for 24 h at 140C to give a suspension. It was cooled to RT. Water (50mL) was added: the product precipitated on stirring/sonication. The solid was filtered, washed with water, and extracted with dichloromethane and water. The organic layer was washed with water to extract DMSO. Purification by chromatography on silica (20g) removed the starting materials and by-products on elution with 0-0.4% CH3OH in CH2Cl2, and provided the pure product on elution with 0.4-1.0% CH3OH in CH2Cl2. Anal. Calc. for C14H12N4 (MW 236.27): C, 71.17; H, 5.12; N, 23.71. Found: C, 71.44; H, 5.10; N, 24.05%.
 

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