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Chemical Structure| 161609-85-4 Chemical Structure| 161609-85-4

Structure of 161609-85-4

Chemical Structure| 161609-85-4

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Product Details of [ 161609-85-4 ]

CAS No. :161609-85-4
Formula : C14H19N3O3
M.W : 277.32
SMILES Code : O=C(N1CCC(C(NO)=N)CC1)OCC2=CC=CC=C2
MDL No. :MFCD28109829

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Application In Synthesis of [ 161609-85-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 161609-85-4 ]

[ 161609-85-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 161609-84-3 ]
  • [ 161609-85-4 ]
YieldReaction ConditionsOperation in experiment
With hydroxylamine hydrochloride; sodium carbonate; In ethanol; dichloromethane; water; b. 1-Benzyloxycarbonyl-4-piperidinecarboxamideoxime A solution of hydroxylamine hydrochloride (0.340 g) in water (5 mL) was treated with sodium carbonate (0.26 g), followed by a solution of <strong>[161609-84-3]1-benzyloxycarbonyl-4-cyanopiperidine</strong> (1.00 g) in ethanol (10 mL). The resulting mixture was heated under reflux for 3 hours. Additional hydroxylamine hydrochloride (0.340 g) and sodium carbonate (0.26 g) were added, and the mixture was heated at reflux for an additional 14 hours. The mixture was cooled and evaporated. The semisolid residue was suspended in dichloromethane, filtered and the solid product dried to afford the carboxamideoxime as a white solid (0.70 g); mp 111-113 C.; NMR: 8.83 (s,1), 7.35 (m, 5), 5.33 (broad s, 2), 5.07 (s,2), 4.02 (broad d, 2, J=13.1), 2.80 (broad, 2), 2.19 (m, 1), 1.69 (broad d, 2, J=11.0), 1.55-1.42 (m, 2); MS: m/z=278(M+1).
 

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