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Chemical Structure| 161735-79-1 Chemical Structure| 161735-79-1

Structure of Rasagiline Mesylate
CAS No.: 161735-79-1

Chemical Structure| 161735-79-1

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Rasagiline Mesylate is an irreversible and selective MAO-B inhibitor used in early Parkinson's disease.

Synonyms: TVP1012 mesylate; (R)-AGN1135 mesylate

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Product Details of Rasagiline Mesylate

CAS No. :161735-79-1
Formula : C13H17NO3S
M.W : 267.34
SMILES Code : C#CCN[C@@H]1CCC2=C1C=CC=C2.CS(=O)(O)=O
Synonyms :
TVP1012 mesylate; (R)-AGN1135 mesylate
MDL No. :MFCD08460604
InChI Key :JDBJJCWRXSVHOQ-UTONKHPSSA-N
Pubchem ID :3052775

Safety of Rasagiline Mesylate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Rats Healthy rats Intranasal administration 8 mg/kg or 12 mg/kg Every 24 hours for 7 weeks Evaluate the brain-targeting efficiency of intranasal administration, results showed significantly higher brain-targeting efficiency compared to intravenous administration PMC9981512
Wistar Albino rats Parkinson's disease model Intranasal administration 12 mg/kg Once daily for 8 weeks To evaluate the brain targeting efficiency of intranasally administered rasagiline mesylate transferosomal gel, the results showed a brain bioavailability of 131.17%, indicating that intranasal administration significantly improved brain targeting of the drug. PMC9967009
Rats 6-hydroxydopamine-induced Parkinson's disease model Intramuscular injection 0.05 mg/kg/day Single dose Evaluate the therapeutic effect of Rasagiline Mesylate microsphere-gel in situ forming implant system on Parkinson's disease model rats. The results showed that the system significantly reduced apomorphine-induced rotational behavior and effectively increased dopamine levels in the lesioned striatum. PMC6058670

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01280123 Parkinson's Disease Phase 2 Completed - -
NCT01280123 - Completed - -
NCT01155466 Parkinson Disease Phase 3 Completed - -
NCT01155479 Parkinson Disease Phase 3 Terminated(Termininated for bu... More >>siness reasons) Less << - -
NCT02696512 Brain Injury Phase 1 Phase 2 Unknown April 2017 United States, New Jersey ... More >> International Brain Research Foundation Recruiting Edison, New Jersey, United States, 08837 Contact: Philip Defina, PhD    732-494-7600    pdefina@ibrfinc.org    Principal Investigator: Philip Defina, PhD Less <<
NCT01155466 - Completed - -
NCT03329508 Parkinson Disease Phase 3 Recruiting December 30, 2019 -
NCT01155479 - Terminated(Termininated for bu... More >>siness reasons) Less << - -
NCT01215227 Parkinson Disease ... More >> Idiopathic Parkinson Disease Less << Phase 3 Terminated - -
NCT01098396 - Unknown - -
NCT00203125 Parkinson's Disease Phase 3 Completed - -
NCT01968460 Parkinson's Disease Phase 2 Phase 3 Completed - -
NCT02789020 Parkinson's Disease Phase 2 Recruiting December 2020 United States, Florida ... More >> Laboratory for Rehabilitation Neuroscience Recruiting Gainesville, Florida, United States, 32611 Contact: Nieci Black    352-294-1771    nblack@ufl.edu Less <<
NCT00902941 Parkinson′s Disease Phase 4 Completed - Germany ... More >> University of Dresden Medical School, Smell & Taste Centre, Dept. of Neurology Dresden, Germany, 01307 Less <<
NCT01215227 - Terminated - -
NCT01532128 Parkinson Disease Phase 1 Completed - France ... More >> BIOTRIAL Rennes, France, F-35000 Less <<
NCT02207387 Parkinson's Disease Not Applicable Unknown March 2017 Canada, British Columbia ... More >> Pacific Parkinson's Research Centre Recruiting Vancouver, British Columbia, Canada, V6P 2Z9 Principal Investigator: Martin J McKeown, MD Less <<
NCT00203060 Parkinson's Disease Phase 3 Completed - -
NCT01048229 Early-stage Parkinson's Diseas... More >>e Less << Phase 4 Terminated(recruitment) - -
NCT00492336 Schizophrenia Phase 4 Completed - United States, Maryland ... More >> Baltimore VA Medical Center Baltimore, Maryland, United States, 21201 Keypoint Mental health Center Catonsville, Maryland, United States, 21228 Maryland Psychiatric REsearch Center Catonsville, Maryland, United States, 21228 Mosaic Community Mental health Center Catonsville, Maryland, United States, 21228 Keypoint Mental health Center Dundalk, Maryland, United States, 21222 Less <<
NCT00104273 Dementia Alzh... More >>eimer's Disease Less << Phase 2 Completed - -
NCT00492336 - Completed - -
NCT00256204 Parkinson's Disease Phase 3 Completed - -
NCT00256204 - Completed - -
NCT00203034 Parkinson's Disease Phase 3 Completed - United States, Illinois ... More >> Rush - Presbyterian St. Luke's Medical Center Chicago, Illinois, United States, 60612 United States, New York Columbia - Presbyterian Medical Center New York, New York, United States, 10032 University of Rochester Rochester, New York, United States, 14642 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Less <<
NCT02359552 Alzheimer's Disease Phase 2 Active, not recruiting February 15, 2019 United States, Nevada ... More >> Cleveland Clinic Lou Ruvo Center for Brain Health Las Vegas, Nevada, United States, 89106 United States, Ohio Cleveland Clinic Main Campus Cleveland, Ohio, United States, 44195 Cleveland Clinic Lakewood Hospital Lakewood, Ohio, United States, 44107 Less <<
NCT02068625 Retinal Detachment Phase 4 Active, not recruiting December 31, 2018 Switzerland ... More >> Department of Ophthalmology, Bern University Hospital Bern, Switzerland, 3010 Less <<
NCT01382342 Parkinson's Disease Phase 4 Completed - United States, Rhode Island ... More >> Butler Hospital Providence, Rhode Island, United States, 02906 Less <<
NCT01765257 Drug-na?ve Patients With Parki... More >>nson's Disease Apathy Less << Phase 4 Unknown March 2015 France ... More >> CHU Clermont-Ferrand Not yet recruiting Clermont-Ferrand, France, 63003 Contact: Patrick LACARIN    04 73 75 11 95    placarin@chu-clermontferrand.fr Less <<
NCT01049984 Parkinson's Disease Phase 4 Completed - -
NCT00203138 Parkinson's Disease Phase 3 Completed - -
NCT01532128 - Completed - -
NCT01055379 Depressive Symptoms ... More >> Parkinson's Disease Less << Phase 4 Completed - Italy ... More >> IT010 Cagliari, Italy, 9134 IT007 Chieti, Italy, 66013 IT004 Genova, Italy, 16132 IT005 Lido di Camaiore, Italy, 55043 IT003 Messina, Italy, 98122 IT012 Milano, Italy, 20135 IT001 Naples, Italy, 80131 IT011 Roma, Italy, 161 IT008 Rome, Italy, 133 IT015 Torino, Italy, 10126 IT013 Venezia, Italy, 30126 IT009 Verona, Italy, 37134 Less <<
NCT02278588 - Unknown December 2016 United States, New York ... More >> University at Buffalo Buffalo, New York, United States, 14214 Less <<
NCT01187888 Progressive Supranuclear Palsy Phase 3 Terminated(IMP used off label ... More >>by phys. in pat. with PSP. Thus no more eligible patients were available for the study(pre-treatm.with Rasagiline=exclusion criterion) Less << - Germany ... More >> Department of Neurology and Palliative Care Klinikum der Universität München (Hospital of the University of Munich) München, Germany, 81377 Less <<
NCT01385735 Parkinson Disease Phase 4 Unknown April 2013 Germany ... More >> St. Josef Hospital Not yet recruiting Bochum, Nordrhein-Westfalen, Germany, 44791 Principal Investigator: Dirk Woitalla, MD          Sub-Investigator: Irene Daum, Prof. Less <<
NCT01049984 - Completed - -
NCT00955604 - Completed - -
NCT01268891 Parkinson's Disease Phase 3 Completed - -
NCT00696215 Parkinson's Disease Phase 4 Unknown October 2008 Turkey ... More >> Marmara University Recruiting Istanbul, Turkey Contact: NESE TUNCER          Raif Cakmur Recruiting Izmir, Turkey Contact: RAIF CAKMUR, PROF.DR Less <<
NCT01007630 Parkinson's Disease Phase 4 Unknown January 2014 United States, California ... More >> The Parkinson's Institute Sunnyvale, California, United States, 94085 Less <<
NCT00399477 Parkinson's Disease Phase 4 Completed - -
NCT01497652 Parkinson's Disease Phase 4 Completed - United States, District of Col... More >>umbia Georgetown University Hospital Washington, District of Columbia, United States, 20007 Less <<
NCT01532141 Parkinson Disease Phase 1 Completed - France ... More >> BIOTRIAL Rennes, France, F-35000 Less <<
NCT01479530 Parkinson's Disease Phase 3 Completed - China ... More >> CN015 Beijing, China, 100034 CN008 Beijing, China, 100050 CN017 Beijing, China, 100050 CN001 Beijing, China, 100730 CN018 Beijing, China, 100730 CN011 Chengdu, China, 610041 CN003 Guangzhou, China, 510120 CN005 Guangzhou, China, 510180 CN004 Hangzhou, China, 310009 CN019 Qingyu Zhou, China, 510260 CN020 Qingyu Zhou, China, 510260 CN012 Shanghai, China, 200025 CN007 Shanghai, China, 200040 CN013 Shanghai, China, 200127 CN006 Suzhou, China, 215004 CN009 Wuhan, China, 430022 CN010 Xi'an, China, 710032 CN014 Zi'an, China, 710061 Less <<
NCT01879241 Amyotrophic Lateral Sclerosis Phase 2 Completed - Germany ... More >> Department of Neurology, University of Ulm Ulm, Baden-Württemberg, Germany, 89081 Department of Neurology, Technische Universität München Muenchen, Bayern, Germany, D-81675 Department of Neurology, Universty of Regensburg Regensburg, Bayern, Germany, D-93053 Department of Neurology, University of Wuerzburg Wuerzburg, Bayern, Germany, 91054 Department of Neurology, Deutsche Klinik für Diagnostik Wiesbaden, Hessen, Germany, D-65191 Department of Neurology, University of Rostock Rostock, Mecklenburg-Vorpommern, Germany, D-18147 Department of Neurology, University of Goettingen Goettingen, Niedersachsen, Germany, D-37073 Department of Neurology, Medical School Hannover Hannover, Niedersachsen, Germany, 30625 Neurologische Universitätsklinik Bergmannsheil Bochum, Nordrhein-Westfalen, Germany, 44789 Department of Neurology, Universty of Muenster Muenster, Nordrhein-Westfalen, Germany, D-48149 Department of Neurology, Universty of Bonn Bonn, Nordrhrein-Westfalen, Germany, D-53105 Department of Neurology, University of Halle-Wittenberg Halle/Saale, Sachsen-Anhalt, Germany, 06097 Department of Neurology, TU Dresden Dresden, Sachsen, Germany, D-01307 Department of Neurology, University of Jena Jena, Thueringen, Germany, D-07747 Department of Neurology, Humboldt University Berlin, Germany, 13353 Less <<
NCT01479530 - Completed - -
NCT01723228 Parkinson's Disease Phase 4 Completed - -
NCT01556165 Parkinson's Disease Phase 3 Completed - China ... More >> CN015 Beijing, China, 100034 CN001 Beijing, China, 100730 CN011 Chengdu, China, 610041 CN003 Guangzhou, China, 510120 CN005 Guangzhou, China, 510180 CN017 Guangzhou, China, 510260 CN004 Hangzhou, China, 310009 CN012 Shanghai, China, 200025 CN007 Shanghai, China, 200040 CN013 Shanghai, China, 200127 CN006 Suzhou, China, 215004 CN009 Wuhan, China, 430022 CN016 Wuhan, China, 430030 CN010 Xi'an, China, 710032 CN014 Xi'an, China, 710061 Less <<
NCT01556165 - Completed - -
NCT00755027 Parkinson's Disease Phase 4 Completed - Spain ... More >> Fundacio de Gestio Sanitaria de l'Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Less <<
NCT01232738 Amyotrophic Lateral Sclerosis ... More >>(ALS) Less << Phase 2 Completed - United States, Arizona ... More >> Phoenix Neurological Institute Phoenix, Arizona, United States, 85018 United States, California California Pacific Medical Center San Francisco, California, United States, 94118 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Kansas University Of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Minnesota University of Minnesota Minneapolis, Minnesota, United States, 55414 United States, Nebraska University of Nebraska Medical Center Omaha, Nebraska, United States, 68198 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Tennessee University of Tennessee Memphis, Tennessee, United States, 38104 United States, Texas The Methodist Hospital System Houston, Texas, United States, 77030 Canada, Quebec McGill University Montreal, Quebec, Canada, H3A 2B4 Less <<
NCT01723228 - Completed - -
NCT01192503 Restless Legs Syndrome Phase 2 Phase 3 Terminated(Slow enrollment) - United States, Florida ... More >> Advent Research Pinellas Park, Florida, United States, 33781 United States, Georgia Medical College of Georgia Movements Disorders Program Augusta, Georgia, United States, 30912 United States, Illinois Northwestern University PD and Movement Disorders Center Chicago, Illinois, United States, 60611 United States, New Jersey Atlantic Neuroscience Institute Overlook Hospital Summit, New Jersey, United States, 07902 United States, New York SUNY- Buffalo Jacobs Neurological Institute Buffalo, New York, United States, 14203 United States, Ohio Cleveland Clinic Sleep Disorders Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania University of Pennsylvania Sleep Center Philadelphia, Pennsylvania, United States, 19104 United States, Virginia Charlottesville Medical Research Charlottesville, Virginia, United States, 22911 Less <<
NCT01268891 - Completed - -
NCT02384512 - Completed - -
NCT01532141 - Completed - -
NCT01232738 - Completed - -
NCT01652313 Parkinson's Disease Phase 1 Completed - China ... More >> CN001 Beijing, China Less <<
NCT01168596 - Completed - -
NCT01786603 Amyotrophic Lateral Sclerosis ... More >>(ALS) Less << Phase 2 Active, not recruiting August 2017 United States, Arizona ... More >> Phoenix Neurological Associates Phoenix, Arizona, United States, 85018 United States, California University of California - Irvine Irvine, California, United States, 92868 California Pacific Medical Center San Francisco, California, United States, 94115 United States, Kansas University of Kansas Medical Center Kansas City, Kansas, United States, 66160 United States, Missouri St. Louis University Saint Louis, Missouri, United States, 63104 United States, Nebraska University of Nebraska Omaha, Nebraska, United States, 68198 United States, New York Columbia University New York, New York, United States, 10032 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19107 United States, Texas UT Southwestern Medical Center Dallas, Texas, United States, 75390 Less <<
NCT01736891 Parkinson′s Disease Phase 3 Completed - China ... More >> CN002 Chengdu, China, 610041 CN005 Chenzhou, China, 423000 CN007 Chongqing, China, 404000 CN003 Guilin, China, 541001 CN004 Lanzhou, China, 730050 CN006 Luzhou, China, 646000 CN008 Nanjing, China, 210029 CN001 Xi'an, China, 710032 Less <<
NCT01178047 Parkinson's Disease Phase 4 Terminated(payments stopped by... More >> grant provider) Less << - Switzerland ... More >> University Hospital, Neurology Zurich, ZH, Switzerland, CH-8091 Neurocentro, Lugano Lugano, Switzerland Less <<
NCT01442610 Sleep Disturbances ... More >> Parkinsons's Disease Less << Phase 4 Completed - Germany ... More >> Dresden University of Technology, Dept. of Neurology Dresden, Germany, 01307 Less <<
NCT00203177 Parkinson's Disease Phase 3 Completed - United States, California ... More >> Margolin Brain Institute Fresno, California, United States, 93720 United States, Georgia Emory University Atlanta, Georgia, United States, 30329 United States, Illinois Rush - Presbyterian St. Luke's Medical Center Chicago, Illinois, United States, 60612 United States, Nebraska Creighton University Omaha, Nebraska, United States, 68131 United States, New York Long Island Jewish Medical Center New Hyde Park, New York, United States, 11040 University of Rochester Rochester, New York, United States, 14642 United States, Pennsylvania Pennsylvania Hospital Philadelphia, Pennsylvania, United States, 19107 Canada, Quebec CHUM-Hotel-Dieu Montreal, Quebec, Canada, H2w1T8 Less <<
NCT00977665 Multiple System Atrophy Phase 2 Completed - -
NCT00936676 - Completed - -
NCT01032486 - Completed - -
NCT00977665 - Completed - -
NCT03727139 - Recruiting October 31, 2021 Japan ... More >> Takeda Selected Site Recruiting Tokyo, Japan Less <<
NCT01168596 Parkinson's Disease Phase 4 Completed - United States, Colorado ... More >> University of Colorado Anschutz outpatient Pavilion Aurora, Colorado, United States, 80045 United States, Florida Shands and University of Florida Medical Plaza Gainesville, Florida, United States, 32610 United States, Ohio Cleveland Clinic Center for Neurological Restoration Cleveland, Ohio, United States, 44195 Less <<
NCT00203164 Parkinson's Disease Phase 3 Completed - United States, California ... More >> Margolin Brain Institute Fresno, California, United States, 93720 United States, Illinois Rush - Presbyterian St. Luke's Medical Center Chicago, Illinois, United States, 60612 United States, Nebraska Creighton University Omaha, Nebraska, United States, 68131 United States, New York Long Island Jewish Medical Center New Hyde Park, New York, United States, 11040 University of Rochester Rochester, New York, United States, 14642 United States, Pennsylvania Pennsylvania Hospital Philadelphia, Pennsylvania, United States, 19107 Less <<
NCT01879748 Parkinson's Disease Phase 1 Completed - United States, California ... More >> Teva Investigational Site 10738 Glendale, California, United States Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.74mL

0.75mL

0.37mL

18.70mL

3.74mL

1.87mL

37.41mL

7.48mL

3.74mL

References

 

Historical Records

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