Home Cart Sign in  
Chemical Structure| 1634-46-4 Chemical Structure| 1634-46-4

Structure of 1634-46-4

Chemical Structure| 1634-46-4

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1634-46-4 ]

CAS No. :1634-46-4
Formula : C8H8N2OS
M.W : 180.23
SMILES Code : NC1=NC(C2=CC=C(C)O2)=CS1
MDL No. :MFCD00503492
InChI Key :HIBFSFCLIHHSJZ-UHFFFAOYSA-N
Pubchem ID :2113305

Safety of [ 1634-46-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1634-46-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1634-46-4 ]

[ 1634-46-4 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 1634-53-3 ]
  • [ 17356-08-0 ]
  • [ 1634-46-4 ]
YieldReaction ConditionsOperation in experiment
29% In ethanol; at 80℃; for 2.0h; The compound IN-1 (540 mg, 2.67 mmol) and thiourea (244 mg, 3.21 mmol) in ethanol (10 mL) were heated to 80 C for 2 hours.After the reaction mixture was cooled to room temperature, the ethanol was spun off.Add 20 mL of water and stir for 10 minutes, filter, filter cake twice with water, and finally spin the filter cake to give 4-(5-methylfuran-2-yl)thiazole-2-amine (140 mg,Yield 29%, white solid).
1 eq of substituted 2-bromoacetone, 1 eq of thiourea then 2 ml of EtOH are introduced into a 2-5 mL tube suitable for microwaves (Personal Chemistry). The solution is pre-stirred for 15 s in the apparatus at room temperature and is then heated for 4 min at 170 C. The progress of the reaction is evaluated by TLC and LC-MS. After hydrolysis by H2O and NaHCO3 (to pH = 9-10), the aqueous phase is extracted with AcOEt. The organic phases are washed with a saturated NaCl solution, dried over MgSO4, filtered and concentrated. Analysis of the crude product (1H NMR, LC-MS) shows that purification is unnecessary. The substituted amino-thiazoles obtained are used directly in urea synthesis reactions.; 4-(5-methyl-furan-2-yl)-thiazoI-2-yl-amine (Method 4)Method 4 above was used to prepare the aforementioned product.1H NMR (400 MHz, CDCl3): δ 6.62 (s, IH, HtM220,.), 6.51 (d, IH, Hfuran), 6.03 (d, IH, Hfuran),5.20-5.08 (m, 2H, NH2), 2.36 (s, 3H, CH3)MS: 181.06 (M+H)+Rf: 0.20 (silica, heptane/AcOEt 1/1)
  • 2
  • [ 1193-79-9 ]
  • [ 1634-46-4 ]
  • 3
  • [ 1634-46-4 ]
  • 5-(2-amino-4-(5-methylfuran-2-yl)thiazol-5-yl)-1-isopropylpyridine-2(1H)-one [ No CAS ]
  • 4
  • [ 1634-46-4 ]
  • 5-bromo-4-(5-methylfuran-2-yl)thiazol-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 0 - 30℃; 0 C To a solution of compound IN-2 (140 mg, 0.78 mmol) in DMF (10 mL)0.85 mmol), the reaction mixture was allowed to warm to room temperature overnight. After the reaction was completed, the mixture was poured into water and treated with DCM/MeOH.(10:1) extraction three times, the organic phase is combined, washed three times with water, once with saturated brine, dried over anhydrous sodium sulfate, filtered, reducedThe solvent was evaporated to give 5-bromo-<strong>[1634-46-4]4-(5-methylfuran-2-yl)thiazol-2-amine</strong> (100 mg, yield 49%, brown solid).
  • 5
  • [ 208051-67-6 ]
  • [ 1634-46-4 ]
  • 4-methoxy-2-methyl-N-(4-(5-methylfuran-2-yl)thiazol-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamide-1,1-dioxide [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With sodium methylate; In toluene;Sonication; General procedure: Benzothiazine carboxylate (4) (1 mmol), azolyl amine (5-13) (1 mmol) and 5 mol% sodium methoxide (5 ml) in toluene were taken and sonicated at a frequency of 35 kHz for 3-5 h. The solvent was removed on a rotary evaporator and the resultant solid was recrystallized from ethanol.
 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 1634-46-4 ]

Amines

Chemical Structure| 28989-52-8

A354555 [28989-52-8]

4-(Furan-2-yl)thiazol-2-amine

Similarity: 0.99

Chemical Structure| 3084-04-6

A927829 [3084-04-6]

4-(Benzofuran-2-yl)thiazol-2-amine

Similarity: 0.90

Chemical Structure| 24614-21-9

A159543 [24614-21-9]

4-(5-Bromofuran-2-yl)thiazol-2-amine

Similarity: 0.89

Chemical Structure| 886494-24-2

A303865 [886494-24-2]

4-(5-(3,4-Dichlorophenyl)furan-2-yl)thiazol-2-amine

Similarity: 0.84

Related Parent Nucleus of
[ 1634-46-4 ]

Furans

Chemical Structure| 28989-52-8

A354555 [28989-52-8]

4-(Furan-2-yl)thiazol-2-amine

Similarity: 0.99

Chemical Structure| 24614-21-9

A159543 [24614-21-9]

4-(5-Bromofuran-2-yl)thiazol-2-amine

Similarity: 0.89

Chemical Structure| 886494-24-2

A303865 [886494-24-2]

4-(5-(3,4-Dichlorophenyl)furan-2-yl)thiazol-2-amine

Similarity: 0.84

Thiazoles

Chemical Structure| 28989-52-8

A354555 [28989-52-8]

4-(Furan-2-yl)thiazol-2-amine

Similarity: 0.99

Chemical Structure| 3084-04-6

A927829 [3084-04-6]

4-(Benzofuran-2-yl)thiazol-2-amine

Similarity: 0.90

Chemical Structure| 24614-21-9

A159543 [24614-21-9]

4-(5-Bromofuran-2-yl)thiazol-2-amine

Similarity: 0.89

Chemical Structure| 886494-24-2

A303865 [886494-24-2]

4-(5-(3,4-Dichlorophenyl)furan-2-yl)thiazol-2-amine

Similarity: 0.84