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[ CAS No. 1638-86-4 ]

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2D
Chemical Structure| 1638-86-4
Chemical Structure| 1638-86-4
Structure of 1638-86-4 *Storage: {[proInfo.prStorage]}

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Product Details of [ 1638-86-4 ]

CAS No. :1638-86-4MDL No. :MFCD00009086
Formula : C10H15O2P Boiling Point : 235°C at 760 mmHg
Linear Structure Formula :-InChI Key :N/A
M.W :198.20Pubchem ID :-
Synonyms :

Computed Properties of [ 1638-86-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 1638-86-4 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1638-86-4 ]

  • Downstream synthetic route of [ 1638-86-4 ]

[ 1638-86-4 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 506-68-3 ]
  • [ 1638-86-4 ]
  • [ 120232-75-9 ]
YieldReaction ConditionsOperation in experiment
89% In diethyl ether for 1h; Ambient temperature;
  • 3
  • [ 64-17-5 ]
  • [ 644-97-3 ]
  • [ 1638-86-4 ]
YieldReaction ConditionsOperation in experiment
95.5% With <i>N</i>,<i>N</i>-dimethyl-aniline In pentane for 0.5h; Ambient temperature;
87.5% at 0 - 45℃; for 2.5h; Alkaline conditions; Sealed tube; 2.2 (2) Synthesis of diethyl phenylphosphonate In the electric liquid seal stirring device, constant pressure dropping funnel,In a 250-ml four-necked flask with a thermometer and a bulb-type condenser tube (upper section equipped with a drying tube), 0.4 mol of absolute ethanol and 10 ml of basic ionic liquid were added. Add 0.1 mol of phenylphosphonium dichloride to the constant pressure dropping funnel with stirring, use the ice water bath and adjust the dropping speed of phenylphosphine dichloride, The reaction temperature was controlled at about 0C, and after completion of the dropwise addition, the mixture was stirred at about 45C for 2.5 hours. After the reaction is completed, the reaction solution is poured into a beaker, cooled and filtered to obtain a solid crude product of diethyl phenylphosphonate. The product was recrystallized from a mixture of petroleum ether and dichloromethane to obtain a pure product with a yield of 87.5%.
86% With pyridine In diethyl ether for 1h; Ambient temperature;
75% With amine
71% Stage #1: Dichlorophenylphosphine With pyridine In hexane Inert atmosphere; Cooling with ice; Stage #2: ethanol In hexane at 0 - 26℃; for 17h; Inert atmosphere;
65% at 20 - 25℃;
58% With N,N-diethylaniline In diethyl ether at 5 - 20℃;
With <i>N</i>,<i>N</i>-dimethyl-aniline
With <i>N</i>,<i>N</i>-dimethyl-aniline In diethyl ether Ambient temperature;
With sodium ethanolate
With pyridine
With pyridine In hexane for 3h; Ambient temperature;
70 g In toluene
With triethylamine
With pyridine In Petroleum ether
In diethyl ether at -20℃; for 2h; Inert atmosphere;
With pyridine In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;

Reference: [1]Boetzel, Ruth; Haegele, Gerhard [Journal of Fluorine Chemistry, 1994, vol. 68, # 1, p. 11 - 14]
[2]Current Patent Assignee: CHANGZHOU VOCATIONAL INSTITUTE OF ENGINEERING - CN107501322, 2017, A Location in patent: Paragraph 0042; 0044; 0045; 0062
[3]Germanaud, Laurent; Brunel, Sylvian; Chevalier, Yves; Le Perchec, Pierre [Bulletin de la Societe Chimique de France, 1988, # 4, p. 699 - 704]
[4]Blazewska, Katarzyna M. [Journal of Organic Chemistry, 2014, vol. 79, # 1, p. 408 - 412]
[5]Bagi, Péter; Fogassy, Elemér; Herbay, Réka; Holczbauer, Tamás; Keglevich, György; Mátravölgyi, Béla; Madarász, János; Székely, György; Varga, Bence [European Journal of Organic Chemistry, 2020]
[6]Location in patent: experimental part Krutikova; Krutikov; Erkin [Russian Journal of General Chemistry, 2010, vol. 80, # 3, p. 428 - 433]
[7]Kaźmierczak, Aleksandra; Kusy, Damian; Niinivehmas, Sanna P.; Gmach, Joanna; Joachimiak, Łukasz; Pentikäinen, Olli T.; Gendaszewska-Darmach, Edyta; Błazewska, Katarzyna M. [Journal of Medicinal Chemistry, 2017, vol. 60, # 21, p. 8781 - 8800]
[8]Kamai [Zhurnal Obshchei Khimii, 1948, vol. 18, p. 443,445,446][Chem.Abstr., 1948, p. 7723]
[9]Coskran,K.J. et al. [Journal of the American Chemical Society, 1968, vol. 90, p. 5437 - 5442]
[10]Green,M.; Hudson,R.F. [Journal of the Chemical Society, 1963, p. 540 - 547]
[11]Siddall,T.H.; Prohaska,C.A. [Journal of the American Chemical Society, 1962, vol. 84, p. 3467 - 3473] Chernyshev,E.A. et al. [Doklady Chemistry, 1962, vol. 147, p. 967 - 968][Doklady Akademii Nauk SSSR, 1962, vol. 147, p. 117 - 118]
[12]Collins, David J.; Drygala, Peter F.; Swan, John M. [Australian Journal of Chemistry, 1983, vol. 36, # 10, p. 2095 - 2110]
[13]Wieczorek, J. S.; Boduszek, B.; Wielkopolski, W. A.; Gancarz, R.; Jaskulska, E. [Journal fur praktische Chemie (Leipzig 1954), 1987, vol. 329, # 1, p. 165 - 170]
[14]Morise, Xavier; Savignac, Philippe; Denis, Jean-Marc [Journal of the Chemical Society. Perkin transactions I, 1996, # 17, p. 2179 - 2185]
[15]Chaudhry, Amirah; Hargcr, Martin J. P.; Shuff, Philippa; Thompson, Alison [Journal of the Chemical Society. Perkin transactions I, 1999, # 10, p. 1347 - 1352]
[16]Zhang, Dapeng; Lian, Mingming; Liu, Jia; Tang, Shukun; Liu, Guangzhi; Ma, Cunfei; Meng, Qingwei; Peng, Haisheng; Zhu, Daling [Organic Letters, 2019, vol. 21, # 8, p. 2597 - 2601]
[17]Xu, Shipan; Xie, Jun; Liu, Yu; Xu, Weifeng; Tang, Ke-Wen; Xiong, Biquan; Wong, Wai-Yeung [Journal of Organic Chemistry, 2021, vol. 86, # 21, p. 14983 - 15003]
  • 4
  • [ 13508-53-7 ]
  • [ 1638-86-4 ]
  • [ 839-43-0 ]
  • 6
  • [ 3167-63-3 ]
  • [ 1638-86-4 ]
  • [ 81073-28-1 ]
  • 7
  • [ 10586-45-5 ]
  • [ 1638-86-4 ]
  • [ 91270-79-0 ]
YieldReaction ConditionsOperation in experiment
81% With nickel dibromide In water at 160 - 180℃;
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