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CAS No. : | 163808-13-7 | MDL No. : | MFCD00965006 |
Formula : | C7H4N2O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | SLXGGFDKGANNSL-UHFFFAOYSA-N |
M.W : | 164.12 | Pubchem ID : | 1482181 |
Synonyms : |
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Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | UN#: | |
Hazard Statements: | H302-H312-H315-H319-H332-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With hydrogen In methanol at 20℃; | b) 4-Aminobenzooxazole The above crude 4-nitrobenzooxazole and Pd/C (5percent, 0.51 g) were suspended in MeOH (50 mL). The mixture was shaken under H2 (50 psi) at room temperature overnight. The mixture was filtered through a layer of celite, washed with MeOH. The solvent was evaporated under reduced pressure to yield 6.87 g (100percent) as a light brown solid. 1H NMR (CDCl3): 7.96 (s, 1H), 7.16 (t, J=8.1 Hz, 1H), 6.95 (dd, J=0.9, 8.1 Hz, 1H), 6.61 (dd, J=0.6, 8.1 Hz, 1H), 4.33 (brs, 2H). |
82% | With palladium on activated charcoal; hydrogen In ethanol at 0 - 20℃; Inert atmosphere | The compound obtained in Example 40-1 (600 mg, 3.66 mmol) Palladium on carbon (300 mg) was added at 0 under an argon atmosphere in ethanol (10 ml) solution of. After hydrogen substitution, and stirred at room temperature overnight. After completion of the reaction, it was filtered through Celite, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane / ethyl acetate) to give the title compound (404 mg, 82percent). |