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[ CAS No. 165320-27-4 ] {[proInfo.proName]}

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Chemical Structure| 165320-27-4
Chemical Structure| 165320-27-4
Structure of 165320-27-4 * Storage: {[proInfo.prStorage]}
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Product Details of [ 165320-27-4 ]

CAS No. :165320-27-4 MDL No. :MFCD29089346
Formula : C36H31N Boiling Point : -
Linear Structure Formula :- InChI Key :OZCQPISJVFUHIH-UHFFFAOYSA-N
M.W : 477.64 Pubchem ID :57573242
Synonyms :

Calculated chemistry of [ 165320-27-4 ]

Physicochemical Properties

Num. heavy atoms : 37
Num. arom. heavy atoms : 30
Fraction Csp3 : 0.17
Num. rotatable bonds : 3
Num. H-bond acceptors : 0.0
Num. H-bond donors : 0.0
Molar Refractivity : 157.01
TPSA : 3.24 Ų

Pharmacokinetics

GI absorption : Low
BBB permeant : No
P-gp substrate : Yes
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : Yes
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -2.0 cm/s

Lipophilicity

Log Po/w (iLOGP) : 5.23
Log Po/w (XLOGP3) : 10.16
Log Po/w (WLOGP) : 9.77
Log Po/w (MLOGP) : 7.72
Log Po/w (SILICOS-IT) : 8.88
Consensus Log Po/w : 8.35

Druglikeness

Lipinski : 1.0
Ghose : None
Veber : 0.0
Egan : 1.0
Muegge : 2.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -9.6
Solubility : 0.000000119 mg/ml ; 0.0000000002 mol/l
Class : Poorly soluble
Log S (Ali) : -10.16
Solubility : 0.0000000329 mg/ml ; 0.0000000001 mol/l
Class : Insoluble
Log S (SILICOS-IT) : -13.72
Solubility : 0.0 mg/ml ; 0.0 mol/l
Class : Insoluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 2.0
Synthetic accessibility : 3.8

Safety of [ 165320-27-4 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 165320-27-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 165320-27-4 ]

[ 165320-27-4 ] Synthesis Path-Downstream   1~27

  • 1
  • [ 62-53-3 ]
  • [ 144981-85-1 ]
  • [ 165320-27-4 ]
YieldReaction ConditionsOperation in experiment
56% With [2,2]bipyridinyl; copper(l) iodide; potassium tert-butylate; In 5,5-dimethyl-1,3-cyclohexadiene; for 48h;Inert atmosphere; Reflux; 2-Iodo-9,9-dimethyl-fluorene (6.9384 g, 21 mmol), freshly distilled aniline (0.9622 g, 10 mmol), 2,2-bipyridine (178 mg, ~1 mmol), CuI (232 mg, ~1 mmol) were dissolved in 60 ml xylene, protected with Ar and heated to reflux for 48 h. After cooled to room temperature, the reaction mixture was filtered through Celite and filtrate was washed with toluene. The combined organic layer was washed with brine, dried with Na2SO4. Silica gel column chromatography using CH2Cl2/hexane (v/v=1:3) as eluent gave product as light yellow solid, which was recrystalized from CH3OH to afford colorless crystal (2.5874g), yield 56%. 1H NMR (400 MHz, CDCl3) delta = 7.63 (d, J = 7.3 Hz, 2H), 7.58 (d, J = 8.2 Hz, 2H), 7.38 (d, J = 7.3 Hz, 2H), 7.30 (dd, J = 14.0, 7.0 Hz, 4H), 7.21 (dd, J = 13.1, 4.8 Hz, 4H), 7.05 (t, J = 7.4 Hz, 4H), 1.40 (s, 12H). MS calc: m/z 477.25 ([M+]), TOF-MS found 477.3350 ([M+]).
With 18-crown-6 ether; copper; potassium carbonate; In N,N-dimethyl-formamide; at 160℃; for 24h; Synthesis Example 16 20 parts of <strong>[144981-85-1]9,9-dimethyl-2-iodofluorene</strong>, 2.3 parts of aniline, 19 parts of potassium carbonate, 3.8 parts of copper powders (200 meshes), and 0.57 parts of 18-crown-6 were dissolved in 100 parts of dimethylformamide (DMF), and the obtained solution was reacted in a nitrogen atmosphere at 160C for 24 hours. After completion of the reaction, the reaction product was filtrated, and the filtrate was then extracted with ethyl acetate-water. The ethyl acetate phase was dried over magnesium sulfate, and the ethyl acetate was then distilled away, thereby obtaining a brown tarry substance. This brown tarry substance was separated and purified by column chromatography (hexane-ethyl acetate) to obtain 9.4 parts of 9,9-dimethyl-N-(9,9-dimethylfluorenyl)-N-phenylfluorenamine (the following Compound (357)) in the form of a colorless crystal.
  • 2
  • [ 165320-27-4 ]
  • [ 313050-71-4 ]
YieldReaction ConditionsOperation in experiment
97% With N-Bromosuccinimide In chloroform at 20℃; for 1h;
94% With N-Bromosuccinimide In tetrahydrofuran at 0℃; for 3h; N-(4-bromophenyl)-N-(9,9-dimethyl-9H-fluoren-2-yl)-9,9-dimethyl-9H-fluoren-2-amine (2) 1 (719 mg, 1.51 mmol) was dissolved in 20 ml THF and the solution was cooled to 0 C, N-bromosuccinimide (274 mg, 1.51 mmol) was added in one portion. The reaction mixture was maintained at this temperature and stirred for 3h, then quenched with Na2SO3 (aq) and extracted with CH2Cl2. The combined organic layer was washed with brine, dried with Na2SO4. Silica gel column chromatography using CHCl3/hexane (v/v = 1:3) as eluent gave product as yellow powder (790 mg), yield 94%. 1H NMR (400 MHz, CDCl3) δ = 7.65 (s, 1H), 7.63 (s, 1H), 7.60 (s, 1H), 7.58 (s, 1H), 7.42 - 7.25 (m, 8H), 7.19 (d, J = 1.3 Hz, 2H), 7.06 (d, J = 8.6 Hz, 4H), 1.45 - 1.36 (m, 12H). MS calcd: m/z 555.16 ([M+]), TOF-MS found 555.5070 ([M+]).
With N-Bromosuccinimide In chloroform at 20℃; for 1h;
  • 3
  • [ 165320-27-4 ]
  • [ 313050-72-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: NBS / CHCl3 / 1 h / 20 °C 2: 2N aq. K2CO3 / Pd / tetrahydrofuran / 8 h / 70 °C
  • 4
  • [ 165320-27-4 ]
  • 2-{4-[bis(9,9-dimethylfluorenyl)amino]phenyl}-5-(dimesitylboryl)thiophene [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: NBS / CHCl3 / 1 h / 20 °C 2.1: 2N aq. K2CO3 / Pd / tetrahydrofuran / 8 h / 70 °C 3.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C 3.2: tetrahydrofuran / 14 h / 20 °C
  • 5
  • [ 165320-27-4 ]
  • [ 948560-42-7 ]
YieldReaction ConditionsOperation in experiment
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate In methanol; chloroform at 25 - 50℃; for 3h; 17 4.6 parts of 9,9-dimethyl-N-(9,9-dimethylfluorenyl)-N-phenylfluorenamine (the aforementioned Compound (357)) and 5 parts of benzyltrimethylammonium dichloroiodate were dissolved in a mixed solution of 30 parts of methanol and 70 parts of chloroform. While stirring, 1.8 parts of calcium carbonate was added to the solution. The obtained mixture was then stirred at 25°C for 2 hours, and it was then stirred under heating at 50°C for 1 hour. After completion of the reaction, the reaction solution was extracted with 5% sodium thiosulfate aqueous solution-chloroform. The chloroform phase was dried over magnesium sulfate, and the chloroform was then distilled away, thereby obtaining a yellow-black tarry substance. This yellow-black tarry solid was separated by column chromatography (hexane) and was then recrystallized in hexane-ethanol to obtain 5.1 parts of the following Compound (358) in the form of a colorless crystal.
  • 6
  • [ 33513-42-7 ]
  • [ 165320-27-4 ]
  • [ 916246-05-4 ]
YieldReaction ConditionsOperation in experiment
91% With trichlorophosphate In chloroform Inert atmosphere;
90% With trichlorophosphate at 0 - 20℃; for 48h; Schlenk technique; Inert atmosphere;
88% With trichlorophosphate at 90℃; for 4h; Phosphorus oxychloride (1.30 ml_, 14.13 mmol) was added portion-wise to DMF (1 .1 ml_, 14.13 mmol), not allowing the temperature of the mixture to rise above 5 °C. N,N- bis(9,9-dimethylfluoren-2-yl)aniline (4.50 g, 9.42 mmol) was then added and the resulting mixture was heated at 90 °C for 4 h. The hot reaction mixture was poured into ice-water and neutralized by adding sodium acetate (3.47 g, 42.39 mmol) aqueous solution. After extraction with ethyl acetate and distilled water, the organic layer was dried over anhydrous Na2S0 4, filtered, and solvent was evaporated. The crude product was purified by column chromatography using 3:22 v/v acetone/n-hexane as an eluent to collect compound D3-1 as a yellow solid (4.20 g, 88%).
88% With trichlorophosphate at 5 - 90℃; for 4h; a a) 4-[Bis(9,9-dimethyl-9H-fluoren-2-yl)amino]benzaldehyde (D3-1; corresponds to compound 1 where both radicals R equal 9,9-dimethyl-9H-fluoren-2-yl) Phosphorus oxychloride (1.30 mL, 14.13 mmol) was added portion-wise to DMF (1.1 mL, 14.13 mmol), not allowing the temperature of the mixture to rise above 5° C. N,N-bis(9,9-dimethylfluoren-2-yl)aniline (4.50 g, 9.42 mmol) was then added and the resulting mixture was heated at 90° C. for 4 h. The hot reaction mixture was poured into ice-water and neutralized by adding sodium acetate (3.47 g, 42.39 mmol) aqueous solution. After extraction with ethyl acetate and distilled water, the organic layer was dried over anhydrous Na2SO4, filtered, and solvent was evaporated. The crude product was purified by column chromatography using 3:22 v/v acetone/n-hexane as an eluent to collect compound D3-1 as a yellow solid (4.20 g, 88%). 1H NMR (300 MHz, CDCl3, δ): 9.83 (s, 1H, CHO), 7.76-7.60 (m, 6H), 7.43-7.11 (m, 12H), 1.42 (s, 12H, CH3); 13C NMR (75 MHz, CDCl3, δ): 190.36, 155.37, 153.59, 145.58, 138.47, 136.11, 131.29, 129.21, 127.03, 124.78, 122.55, 120.90, 120.27, 119.96, 119.72, 46.90, 26.96; Anal. calcd for C37H31NO (%): C, 87.89; H, 6.18; N, 2.77. found: C, 87.95; H, 6.27; N, 2.70.
With trichlorophosphate In chloroform for 4h; Reflux;

  • 7
  • [ 108-24-7 ]
  • [ 165320-27-4 ]
  • [ 1284240-04-5 ]
YieldReaction ConditionsOperation in experiment
With tin(IV) chloride In dichloromethane; acetonitrile for 24h; Inert atmosphere; Reflux;
  • 8
  • [ 28320-31-2 ]
  • [ 62-53-3 ]
  • [ 165320-27-4 ]
YieldReaction ConditionsOperation in experiment
64% With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; potassium <i>tert</i>-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In toluene for 20h; Inert atmosphere; Reflux;
  • 9
  • [ 165320-27-4 ]
  • [ 1383782-66-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: N-Bromosuccinimide / chloroform / 1 h / 20 °C 2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 20 h / Inert atmosphere; Reflux 3: N-Bromosuccinimide / chloroform / 1 h / 20 °C
  • 10
  • [ 165320-27-4 ]
  • [ 1389321-71-4 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 20 h / Inert atmosphere; Reflux 3.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 - 0 °C / Inert atmosphere 4.2: 1 h / 0 °C / Inert atmosphere
  • 11
  • [ 165320-27-4 ]
  • [ 1389321-72-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C 2.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 20 h / Inert atmosphere; Reflux 3.1: N-Bromosuccinimide / chloroform / 1 h / 20 °C 4.1: n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 - 0 °C / Inert atmosphere 4.2: 1 h / 0 °C / Inert atmosphere 5.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; 1,2-dimethoxyethane; water / 24 h / 95 °C / Inert atmosphere
  • 12
  • [ 165320-27-4 ]
  • [ 1379677-44-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere
  • 13
  • [ 165320-27-4 ]
  • [ 1379677-45-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere
  • 14
  • [ 165320-27-4 ]
  • [ 1379677-46-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere 4.1: trichlorophosphate / 0 - 70 °C / Inert atmosphere
  • 15
  • [ 165320-27-4 ]
  • [ 1379677-47-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere 4.1: trichlorophosphate / 0 - 70 °C / Inert atmosphere
  • 16
  • [ 165320-27-4 ]
  • [ 1379677-51-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere 4.1: trichlorophosphate / 0 - 70 °C / Inert atmosphere 5.1: 0.5 h / 270 °C
  • 17
  • [ 165320-27-4 ]
  • [ 1379677-50-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere 4.1: trichlorophosphate / 0 - 70 °C / Inert atmosphere 5.1: 0.5 h / 270 °C
  • 18
  • [ 165320-27-4 ]
  • [ 1379677-48-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere 4.1: trichlorophosphate / 0 - 70 °C / Inert atmosphere 5.1: piperidine / chloroform / Reflux
  • 19
  • [ 165320-27-4 ]
  • [ 1379677-49-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere 4.1: trichlorophosphate / 0 - 70 °C / Inert atmosphere 5.1: piperidine / chloroform / Reflux
  • 20
  • [ 165320-27-4 ]
  • [ 1379677-53-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere 4.1: trichlorophosphate / 0 - 70 °C / Inert atmosphere 5.1: 0.5 h / 270 °C 6.1: piperidine / chloroform / Reflux
  • 21
  • [ 165320-27-4 ]
  • [ 1379677-52-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 6 steps 1.1: N-Bromosuccinimide / tetrahydrofuran / 3 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: -78 - 20 °C 3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / tetrahydrofuran; water / 66 h / Reflux; Inert atmosphere 4.1: trichlorophosphate / 0 - 70 °C / Inert atmosphere 5.1: 0.5 h / 270 °C 6.1: piperidine / chloroform / Reflux
  • 22
  • [ 165320-27-4 ]
  • 4-[bis(9,9-dimethyl-9H-fluoren-2-yl)amino]benzaldehyde-N-phenylhydrazone [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: trichlorophosphate / 4 h / 90 °C 2: toluene; isopropyl alcohol / Reflux
Multi-step reaction with 2 steps 1: trichlorophosphate / 4 h / 5 - 90 °C 2: toluene; isopropyl alcohol / Reflux
  • 23
  • [ 165320-27-4 ]
  • 4-[bis(9,9-dimethy-9H-fluoren-2-yl)amino]benzaldehyde-N-(4-formylphenyl)-N-phenylhydrazone [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: trichlorophosphate / 4 h / 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere
Multi-step reaction with 3 steps 1: trichlorophosphate / 4 h / 5 - 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere; Reflux
  • 24
  • [ 165320-27-4 ]
  • 4-[bis(9,9-dimethyl-9H-fluorene-2-yl)amino]benzaldehyde N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-phenylhydrazone [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: trichlorophosphate / 4 h / 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere 4: ammonium acetate; acetic acid / 3.5 h / Reflux
Multi-step reaction with 4 steps 1: trichlorophosphate / 4 h / 5 - 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium carbonate / N,N-dimethyl-formamide / 16 h / Inert atmosphere; Reflux 4: ammonium acetate; acetic acid / 3.5 h / Reflux
  • 25
  • [ 165320-27-4 ]
  • 4-[bis(9,9-dimethyl-9H-fluoren-2-yl)amino]benzaldehyde N-phenyl-N-propylhydrazone [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: trichlorophosphate / 4 h / 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium hydroxide; sodium sulfate / tetrahydrofuran
Multi-step reaction with 3 steps 1: trichlorophosphate / 4 h / 5 - 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium hydroxide; sodium sulfate / tetrahydrofuran; water / 3.5 h
  • 26
  • [ 165320-27-4 ]
  • 4-[bis(9,9-dimethyl-9H-fluoren-2-yl)amino]benzaldehyde-N-4-formylphenyl-N-propylhydrazone [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: trichlorophosphate / 4 h / 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium hydroxide; sodium sulfate / tetrahydrofuran 4: trichlorophosphate / 0.83 h / 60 °C
Multi-step reaction with 4 steps 1: trichlorophosphate / 4 h / 5 - 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium hydroxide; sodium sulfate / tetrahydrofuran; water / 3.5 h 4: trichlorophosphate / 0.83 h / 5 - 60 °C
  • 27
  • [ 165320-27-4 ]
  • 4-[bis(9,9-dimethyl-9H-fluoren-2-yl)amino]benzaldehyde N-4-(3-carboxymethyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidenmethyl)phenyl-N-propylhydrazone [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: trichlorophosphate / 4 h / 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium hydroxide; sodium sulfate / tetrahydrofuran 4: trichlorophosphate / 0.83 h / 60 °C 5: acetic acid / 2 h / Reflux
Multi-step reaction with 5 steps 1: trichlorophosphate / 4 h / 5 - 90 °C 2: toluene; isopropyl alcohol / Reflux 3: potassium hydroxide; sodium sulfate / tetrahydrofuran; water / 3.5 h 4: trichlorophosphate / 0.83 h / 5 - 60 °C 5: acetic acid / 2 h / Reflux
Same Skeleton Products
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