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[ CAS No. 16561-29-8 ] {[proInfo.proName]}

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Chemical Structure| 16561-29-8
Chemical Structure| 16561-29-8
Structure of 16561-29-8 * Storage: {[proInfo.prStorage]}
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Product Citations

Keeney, Justin N. ; Winters, Ashley D. ; Sitcheran, Raquel , et al. DOI: PubMed ID:

Abstract: NF-kB-inducing kinase (NIK), which is essential for the activation of the noncanonical NF-kB pathway, regulates diverse processes in immunity, development, and disease. Although recent studies have elucidated important functions of NIK in adaptive immune cells and cancer cell metabolism, the role of NIK in metabolic-driven inflammatory responses in innate immune cells remains unclear. In this study, we demonstrate that murine NIK-deficient bone marrow derived macrophages exhibit defects in mitochondrial-dependent metabolism and oxidative phosphorylation, which impair the acquisition of a prorepair, anti-inflammatory phenotype. Subsequently, NIK-deficient mice exhibit skewing of myeloid cells characterized by aberrant eosinophil, monocyte, and macrophage cell populations in the blood, bone marrow, and adipose tissue. Furthermore, NIK-deficient blood monocytes display hyperresponsiveness to bacterial LPS and elevated TNF-α production ex vivo. These findings suggest that NIK governs metabolic rewiring, which is critical for balancing proinflammatory and anti-inflammatory myeloid immune cell function. Overall, our work highlights a previously unrecognized role for NIK as a mol. rheostat that fine-tunes immunometabolism in innate immunity, and suggests that metabolic dysfunction may be an important driver of inflammatory diseases caused by aberrant NIK expression or activity.

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Product Details of [ 16561-29-8 ]

CAS No. :16561-29-8 MDL No. :MFCD00036736
Formula : C36H56O8 Boiling Point : -
Linear Structure Formula :- InChI Key :PHEDXBVPIONUQT-RGYGYFBISA-N
M.W : 616.83 Pubchem ID :27924
Synonyms :
Phorbol myristate acetate;TPA;RP-323;PD-616;NSC-262244;12-O-Tetradecanoylphorbol-13-acetate;PMA
Chemical Name :(1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-Acetoxy-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl tetradecanoate

Safety of [ 16561-29-8 ]

Signal Word:Danger Class:6.1,8
Precautionary Statements:P201-P202-P262-P264-P270-P271-P272-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P403+P233-P405-P501 UN#:2928
Hazard Statements:H314-H317-H334-H351-H300+H310+H330 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 16561-29-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 16561-29-8 ]
  • Downstream synthetic route of [ 16561-29-8 ]

[ 16561-29-8 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 17673-25-5 ]
  • [ 16561-29-8 ]
Reference: [1] Zeitschrift für Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie, 1968, vol. 23, # 4, p. 538 - 546
[2] Zeitschrift für Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie, 1968, vol. 23, # 4, p. 538 - 546
  • 2
  • [ 20839-03-6 ]
  • [ 16561-29-8 ]
Reference: [1] Zeitschrift für Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie, 1968, vol. 23, # 4, p. 538 - 546
  • 3
  • [ 20839-03-6 ]
  • [ 108-24-7 ]
  • [ 16561-29-8 ]
Reference: [1] Zeitschrift für Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie, 1968, vol. 23, # 4, p. 538 - 546
  • 4
  • [ 20839-24-1 ]
  • [ 108-24-7 ]
  • [ 16561-29-8 ]
Reference: [1] Zeitschrift für Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie, 1968, vol. 23, # 4, p. 538 - 546
  • 5
  • [ 41621-85-6 ]
  • [ 112-64-1 ]
  • [ 16561-29-8 ]
Reference: [1] Zeitschrift für Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie, 1968, vol. 23, # 4, p. 538 - 546
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