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Chemical Structure| 16618-52-3 Chemical Structure| 16618-52-3

Structure of 16618-52-3

Chemical Structure| 16618-52-3

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Product Details of [ 16618-52-3 ]

CAS No. :16618-52-3
Formula : C9H11NO
M.W : 149.19
SMILES Code : O=CNC1=CC(C)=CC(C)=C1
English Name :N-(3,5-Dimethylphenyl)formamide
MDL No. :MFCD00021015

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Application In Synthesis of [ 16618-52-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 16618-52-3 ]

[ 16618-52-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1780-38-7 ]
  • [ 16618-52-3 ]
  • [ 1097629-29-2 ]
YieldReaction ConditionsOperation in experiment
44% Stage #1: N-(3,5-dimethylphenyl)formamide With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.166667h; Stage #2: 2,4,6-trichloro-5-ethylpyrimidine In N,N-dimethyl-formamide at 0 - 20℃; for 24.1667h; To a stirred solution of N-(3,5-dimethylphenyl)formanilme (8.94 g, 60 mmol) in DMF (60 mL) cooled in an ice bath under nitrogen, was portionwise added 60% sodium hydride (2.88 g, 72 mmol). After 10 min., 2,4,6-trichloro-5-ethyl- pyrimidine (15.2 g, 72 mmol) was added. After stirring for 10 min., the mixture was stirred at room temperature for 24 hr. The mixture was diluted with ether, washed with water three times, dried with MgSOi, filtered, and evaporated in vacuo. The residue was purified by silica gel column chromatography (eluent, ether:hexane(l:10)) to afford 8.6 g (44%) of a white solid, m.p. 124-125°C; m/z(EI) 323 (M*).
 

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