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Chemical Structure| 166328-07-0 Chemical Structure| 166328-07-0

Structure of 166328-07-0

Chemical Structure| 166328-07-0

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Product Details of [ 166328-07-0 ]

CAS No. :166328-07-0
Formula : C10H7BF3K
M.W : 234.07
SMILES Code : F[B-](F)(F)C1=C2C=CC=CC2=CC=C1.[K+]
English Name :Potassium trifluoro(naphthalen-1-yl)borate
MDL No. :MFCD06659936
InChI Key :SBEPDIKXYGSGJL-UHFFFAOYSA-N
Pubchem ID :23670988

Safety of [ 166328-07-0 ]

Application In Synthesis of [ 166328-07-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 166328-07-0 ]

[ 166328-07-0 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 19047-31-5 ]
  • [ 166328-07-0 ]
  • [ 694518-58-6 ]
  • 2
  • [ 53595-65-6 ]
  • [ 166328-07-0 ]
  • [ 1620108-56-6 ]
  • 3
  • [ 13194-67-7 ]
  • [ 131001-86-0 ]
  • [ 166328-07-0 ]
  • [ 2648377-94-8 ]
YieldReaction ConditionsOperation in experiment
40% With palladium diacetate; potassium carbonate; methyl (1S)-bicyclo<2.2.1>hept-2-eno-2-carboxylate In tetrahydrofuran at 110℃; for 24h; Inert atmosphere; Molecular sieve; 12 Example 12: Preparation of Compound I-12 Under the protection of argon, add palladium acetate (2.3mg, 0.01mmol),Potassium carbonate (34.6mg, 0.25mmol), potassium naphthalene trifluoroborate (46.8mg, 0.2mmol), molecular sieve (40.0mg) and dry tetrahydrofuran (0.5mL), Then add (1S,4R)-2-norbornene-2-carboxylic acid methyl ester (7.6mg, 0.05mmol), 4-fluoro-2-iodo-1-methylbenzene (23.6 mg, 0.1 mmol), methyl 2-bromo-3-methylbenzoate (34.4 mg, 0.15 mmol). The resulting mixture is at 110°C, React for 24 hours under argon atmosphere. After the reaction is over, cool to room temperature, the mixture was filtered with celite, washed with ethyl acetate, and distilled under reduced pressure to remove the solvent.Column chromatography was separated and purified to obtain compound I-12 (white solid, yield=40%, d.r.>20:1, e.e.=99%).
 

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