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[ CAS No. 166815-15-2 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 166815-15-2
Chemical Structure| 166815-15-2
Structure of 166815-15-2 *Storage: {[proInfo.prStorage]}

Quality Control of [ 166815-15-2 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 166815-15-2 ]

SDS

Product Details of [ 166815-15-2 ]

CAS No. :166815-15-2MDL No. :MFCD08461902
Formula :C7H17ClN2O2SBoiling Point :-
Linear Structure Formula :-InChI Key :-
M.W :228.74Pubchem ID :44630864
Synonyms :

Computed Properties of [ 166815-15-2 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 166815-15-2 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 166815-15-2 ]

  • Upstream synthesis route of [ 166815-15-2 ]

[ 166815-15-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1143517-68-3 ]
  • [ 166815-15-2 ]
YieldReaction ConditionsOperation in experiment
50%
Stage #1: With hydrogenchloride In 1,4-dioxane at 20℃; for 29.00 h;
Stage #2: With sodium hydroxide In 1,4-dioxane; water
To a solution of this compound (2.1 g, 7.2 mmol, 1 eq) in 1,4-dioxane <n="18"/>(25 mL) add 4 M hydrogen chloride in dioxane (17.95 mL, 72 mmol, 10 eq). Stir at room temperature for 29 hr., basify with 2 M aqueous sodium hydroxide, and then add DCM (20 mL). Separate the layers and extract the aqueous twice with DCM (20 mL), dry the combined organics over magnesium sulphate, filter and concentrate. Extract the aqueous layer a further four times with 3 : 1 chloroform: isopropanol (25 mL).Concentrate the aqueous layer to less than 10 mL volume and extract again with four times with 3: 1 chloroform: isopropanol (25 mL). Combine with all the previous organic extracts to give N-piperidin-4-ylmethyl-methanesulfonamide (703 mg, 50percent). MS (m/z): 193 (M+ 1).
Reference: [1] Patent: WO2009/48765, 2009, A1. Location in patent: Page/Page column 16; 17
Historical Records

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