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Chemical Structure| 166954-93-4 Chemical Structure| 166954-93-4

Structure of 166954-93-4

Chemical Structure| 166954-93-4

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Product Details of [ 166954-93-4 ]

CAS No. :166954-93-4
Formula : C10H13NO3
M.W : 195.22
SMILES Code : O=C(OC)CC(N)C1=CC=C(O)C=C1

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Application In Synthesis of [ 166954-93-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 166954-93-4 ]

[ 166954-93-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 6049-54-3 ]
  • [ 166954-93-4 ]
YieldReaction ConditionsOperation in experiment
80% With thionyl chloride; at 0 - 20℃; for 20h; 5.298 g (29.24 mmol) commercial <strong>[6049-54-3]3-amino-3-(4-hydroxyphenyl)propionic acid</strong> were suspended in 136 ml methanol, the mixture cooled to 0 C and 3.20 ml (43.86 mmol) thionyl chloride were slowly added. The mixture was stirred at room temperature for 20 hours and concentrated. The residue was treated with saturated sodium hydrogen carbonate solution and extracted with dichloromethane and dichloromethane/2-propanol 8:2. The organic part was concentrated to give 5.09 g (80 %) <strong>[6049-54-3]3-amino-3-(4-hydroxyphenyl)propionic acid</strong> methyl ester. UPLC (ACN-HCOOH): Rt. = 0.45 min MS (ES*): m/e = 179.07 (M + H+-NH3) MS (ES -): m/e = 240.30 (M + HCOO-)
 

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