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Structure of 168297-85-6

Chemical Structure| 168297-85-6

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Product Details of [ 168297-85-6 ]

CAS No. :168297-85-6
Formula : C12H15NO2
M.W : 205.25
SMILES Code : O=C1OC(C)(C)[C@H](CC2=CC=CC=C2)N1
MDL No. :MFCD00674020
InChI Key :AEEGFEJKONZGOH-JTQLQIEISA-N
Pubchem ID :10921652

Safety of [ 168297-85-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 168297-85-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 168297-85-6 ]

[ 168297-85-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 168297-85-6 ]
  • [ 459-04-1 ]
  • (S)-4-benzyl-3-(2-(4-fluorophenyl)acetyl)-5,5-dimethyloxazolidine-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
66% To a solution of (S)-4-benzyl-5,5-dimethyloxazolidin-2-one (1 g, 4.87 mmol, 1.0 equiv) in THF (16 ml) at -78 C under argon, n-butyllithium (1.1 equiv, 2.42M in hexanes) was added dropwise. The solution was stirred for 30 min at -78 C. <strong>[459-04-1]4-Fluorophenylacetyl chloride</strong> (1.01 g,5.85 mmol, 1.2 equiv) was added dropwise at -78 C. After stirring at -78 C for 2 h, the reaction mixture was quenchedwith saturated ammonium chloride. The aqueous layer was extracted with ethyl acetate (3 x 20 ml). The combinedorganic layers were washed with brine, dried with sodium sulfate, concentrated in vacuo. The resulting crude productwas purified by column chromatography (silica, 12% ethyl acetate in hexanes) to afford the title compound (1.10 g, 3.23mmol, 66%) as a white solid.
 

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