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[ CAS No. 168476-58-2 ] {[proInfo.proName]}

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Chemical Structure| 168476-58-2
Chemical Structure| 168476-58-2
Structure of 168476-58-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 168476-58-2 ]

CAS No. :168476-58-2 MDL No. :MFCD01570868
Formula : C16H15ClO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 274.74 Pubchem ID :-
Synonyms :

Safety of [ 168476-58-2 ]

Signal Word: Class:N/A
Precautionary Statements: UN#:N/A
Hazard Statements: Packing Group:N/A

Application In Synthesis of [ 168476-58-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 168476-58-2 ]

[ 168476-58-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 493-05-0 ]
  • [ 98-88-4 ]
  • [ 168476-58-2 ]
YieldReaction ConditionsOperation in experiment
100% With zinc(II) chloride In dichloromethane for 1h; Heating;
100% In dichloromethane for 2h; Heating / reflux; 2,3-Benzopyran (40 g, 300 mmol)) was slowly added with stirring to a mixture of zinc chloride (4.2 g, 31 mmol)) and 4.6 g (330 mmol) of benzoyl chloride in 110 mL of dichloromethane. By the end of the addition the mixture was refluxing. The reaction was refluxed for 2 hours. The mixture was cooled to room temperature and 140 mL of water was added with vigorous stirring. The layers were separated and the aqueous layer discarded. The organic layer was washed with water and then brine. The organic layer was filtered through phase separation paper and rotary evaporated to dryness to give 8.5 g (103% yield) of 2-[2-phenylcarbonyloxy)ethyl]benzyl chloride.
99% With zinc(II) chloride In dichloromethane for 2.5h; Reflux; II.1 II, (1) Preparation of 4- (2- (propylamino) ethyl) dihydro-indol-2-one benzoic acid (2-chloromethyl) phenyl ester (10)Compound 9 (65.0g, 484mmol) in 120mL of dichloromethane was added, with stirring, then added zinc chloride (1.95 g of,14.3mmol). After that the reaction mixture was heated to reflux and slowly added dropwise benzoyl chloride (71.5g, 509mmol), continued the Flow for 2.5h. the basic raw material 9 completion of the reaction. The reaction was cooled, washed with water (3 × 200mL), dried over anhydrous sodium sulfate overnight. filter,The filtrate was concentrated under reduced pressure to give a brown crystalline product 132g, 99% yield, m.p. <50 .
99% Stage #1: isochromane With zinc(II) chloride In dichloromethane Reflux; Stage #2: benzoyl chloride for 1.5h; Reflux; 2 (2) benzoic acid (2-chloromethyl) benzene ethyl ester (Compound 3) Compound 2 (65.0g, 484mmol) was added 180mL of dichloromethane, with stirring, was added zinc chloride (1.95g, 14.3mmol). After the reaction mixture was heated to reflux and slowly added dropwise benzoyl chloride (71.5g, 509mmol), dropwise complete, refluxing was continued for 1.5h, the reaction was complete the basic raw material 2. The reaction was cooled, washed with water (3 × 150mL), dried over anhydrous sodium sulfate overnight. Filtered, and the filtrate was concentrated under reduced pressure to give a brown crystalline product 132g, 99% yield, m.p. <50
99% With zinc(II) chloride In dichloromethane for 1.5h; Reflux;
With zinc(II) chloride In dichloromethane at 30 - 35℃;
With zinc(II) chloride In dichloromethane Reflux;

  • 3
  • [ 168476-58-2 ]
  • [ 91374-20-8 ]
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